Background and Objectives: Cancer biomarkers provide information on the characteristics and extent of cancer progression and help inform clinical decision-making. However, they can also play functional roles in oncogenesis, from enabling metastases and inducing angiogenesis to promoting resistance to chemotherapy. The resulting evolution could bias estimates of cancer progression and lead to subop

Knowledge about risks for overuse of psychoactive analgesics in patients having primary surgery for carpal tunnel syndrome (CTS) or ulnar nerve entrapment (UNE), or both, is limited. We investigated if patients with those nerve entrapment disorders have a higher risk of overuse of psychoactive analgesics (i.e., opioids and gabapentinoid drugs) before, after, and both before and after surgery than

Fiber-reinforced composites deliver lightweight but strong structures that are crucial in applications ranging from aerospace to the automotive industry. The advent of freeform injection molding has made the manufacturing of complex fiber-reinforced composites with full design freedom possible. Prediction of the mechanical properties, dictated by the local microfiber orientation, is essential for

Analysing deadlock-freedom, boundedness and realtime constraints are crucial steps in the design of embedded streaming applications. Dataflow models of computation are often used to analyse such properties at design-time. To that end, scenario-based dataflow techniques isolate the individual operating scenarios of a dynamic application and analyse the executions of the possible scenario sequences.

The 1952 General Plan for Stockholm is often seen as Sweden’s most important postwar planning document, sketching the outlines of the social-democratic urban region. In the words of city planning director Sven Markelius, it showcased ”the possibilities for building a townscape, or a milieu, with all its components that satisfy the demands we have on urban life today”. This plan has since acquired The 1952 General Plan for Stockholm is often seen as Sweden’s most important postwar planning document, sketching the outlines of the social-democratic urban region. In the words of city planning director Sven Markelius, it showcased ”the possibilities for building a townscape, or a milieu, with all its components that satisfy the demands we have on urban life today”. This plan has since acquired

The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria, i.e. the increased QRS complex amplitude in defined leads. The classical ECG diagnostic paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces. These increased forces are reflected in the augmented QRS amplitude in the correspond

Recent advances have shown that sound fields can be accurately interpolated between microphone measurements when the spatial covariance matrix is known. This matrix may be estimated in various ways; one promising approach is to use a plane wave formulation with sparse priors, although this may require the use of a many microphones to suppress the noise. To overcome this, we introduce a time domain

Background: It has been reported that caseload midwifery, which implies continuity of midwifery care during pregnancy, childbirth, and the postnatal period, improves the outcomes for the mother and child. The aim of this study was to review benefits and risks of caseload midwifery, compared with standard care comparable to the Swedish setting where the same midwife usually provides antenatal care

The goal of this thesis is to present a methodology for predicting time until recovery of failed wind turbines. The necessity is motivated by the potential for more accurate wind energy export forecasts. The current approach rests entirely on having an expert examine the turbine and produce a time estimate. Due to its nature, such a prediction cannot be made immediately upon failure. Five common s

Objectives: A measurement tool to assess systematic reviews 2 (AMSTAR 2) was originally developed for systematic reviews (SRs) of health-care interventions. The aim of this study was to assess the applicability of AMSTAR 2 to SRs of non-intervention studies. Study design and setting: This was a meta-research study. We used 20 SRs for each of the following four types of SRs: Diagnostic Test Accurac

OBJECTIVES: The aim included investigation of the associations between sedentary (SED), low-intensity physical activity (LIPA), moderate-to-vigorous intensity PA (MVPA) and the prevalence of subclinical atherosclerosis in both coronaries and carotids and the estimated difference in prevalence by theoretical reallocation of time in different PA behaviours.DESIGN: Cross-sectional.SETTING: Multisite

Introduction: Haemophilia A care has changed with the introduction of emicizumab. Experience on the youngest children is still scarce and clinical practice varies between haemophilia treatment centres. Aim: We aimed to assess the current clinical practice on emicizumab prophylaxis within PedNet, a collaborative research platform for paediatricians treating children with haemophilia. Methods: An el

A distinctive representation of image patches in form of features is a key component of many computer vision and robotics tasks, such as image matching, image retrieval, and visual localization. State-of-the-art descriptors, from hand-crafted descriptors such as SIFT to learned ones such as HardNet, are usually high-dimensional; 128 dimensions or even more. The higher the dimensionality, the large

Atmospheric oxygen (O2) concentrations likely remained below modern levels until the Silurian–Devonian, as indicated by several recent studies. Yet, the background redox state of early Paleozoic oceans remains poorly constrained, hampering our understanding of the relationship between early animal evolution and O2. Here, we present a multi-proxy analysis of redox conditions in the Caledonian forel