Evaluation of recombinant human IGF‑1/IGFBP‑3 on intraventricular hemorrhage prevention and survival in the preterm rabbit pup model
Insulin-like growth factor-1 (IGF-1) is essential for normal brain development and regulates processesof vascular maturation. The pathogenesis of intraventricular hemorrhage (IVH) relates to the fragilityof the immature capillaries in the germinal matrix, and its inability to resist fluctuations in cerebralblood flow. In this work, using different experimental setups, we aimed to (i) establish an