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Immunophenotypic characterization and molecular analysis have long been used to delineate heterogeneity and define distinct cell populations. FACS is inherently a single-cell assay, however prior to molecular analysis, the target cells are often prospectively isolated in bulk, thereby losing single-cell resolution. Single-cell gene expression analysis provides a means to understand molecular diffe

Bacteria utilize complement regulators as a means of evading the host immune response. Here, we describe protocols for evaluating the role vitronectin acquisition at the bacterial cell surface plays in resistance to the host immune system. Flow cytometry experiments identified human plasma vitronectin as a ligand for the bacterial receptor outer membrane protein H of Haemophilus influenzae type f.

In the face of reduced public funding of science and increased demands for ‘value for money’, academic researchers find themselves hard pressed to produce relevant research and demonstrate their utility to society. These pressures are particularly prominent in the humanities and social sciences (HSS) where practical value is frequently questioned. This article investigates how HSS can be made ‘rel

From 2012 USA universities entered new partnerships with private sector companies including Silicon Valley start-up Coursera. Coursera spearheads a new broad online learning segment of the fast growing global ‘educational technology’ (EdTech) sector. They offered free ‘massive open online courses’ (MOOCs) for global, universal learner audiences. Since 2015 several USA universities and Coursera exp

Current EU policy calls for decreased emissions of greenhouse gases (GHG) by i.e., replacing fossil fuel in the transportation sector with sustainable biofuels. To avoid indirect land use change (iLUC), the EU at the same time strives to limit the use of crops and to increase the use of residues. In this study we compare climate impact and production cost for biogas and ethanol based on wheat grai

During the last decades, several research groups have used bisphosphonates for local application to counteract secondary bone resorption after bone grafting, to improve implant fixation or to control bone resorption caused by bone morphogenetic proteins (BMps). We focused on zoledronate (a bisphosphonate) due to its greater antiresorptive potential over other bisphosphonates. Recently, it has beco

In recent years, the International Maritime Organization agreed on aiming to reduce shipping's greenhouse gas emissions by 50% with respect to 2009 levels. Meanwhile, cruise ship tourism is growing at a fast pace, making the challenge of achieving this goal even harder. The complexity of the energy system of these ships makes them of particular interest from an energy systems perspective. To illus

Context. The abundance ratio N/O is a useful tool to study the interplay of galactic processes, for example star formation e ciency, timescale of infall, and outflow loading factor. Aims. We aim to trace log(N/O) versus [Fe/H] in the Milky Way and to compare this ratio with a set of chemical evolution models to understand the role of infall, outflow, and star formation e ciency in the building up

This paper assesses a discussion on how to understand the relationship between Husserl’s Cartesian way and the later ontological way to the transcendental reduction: Is the Cartesian way flawed to the extent that the ontological way constitutes a principal correction to it, or is the ontological way a logical completion of an insufficient but nonetheless necessary Cartesian way? A reading with the

Dihadron and isolated direct photon-hadron angular correlations are measured in p+p collisions at s=200 GeV. The correlations are sensitive to nonperturbative initial-state and final-state transverse momenta kT and jT in the azimuthal nearly back-to-back region Δφ∼π. To have sensitivity to small transverse momentum scales, nonperturbative momentum widths of pout, the out-of-plane transverse-moment

A search for dark matter (DM) particles produced in association with a hadronically decaying vector boson is performed using pp collision data at a centre-of-mass energy of s=13 TeV corresponding to an integrated luminosity of 36.1 fb−1, recorded by the ATLAS detector at the Large Hadron Collider. This analysis improves on previous searches for processes with hadronic decays of W and Z bosons in a

We report measurements of the production of prompt D0, D+, D*+ and Ds + mesons in Pb–Pb collisions at the centre-of-mass energy per nucleon-nucleon pair sNN=5.02 TeV, in the centrality classes 0–10%, 30–50% and 60–80%. The D-meson production yields are measured at mid-rapidity (|y| < 0.5) as a function of transverse momentum (pT). The pT intervals covered in central collisions are: 1 < pT< 50 GeV/

In both the Geographic Information (Geo) and Building Information Modelling (BIM) domains, it is widely acknowledged that the integration of data from both domains is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - which can broadly be termed GeoBIM -could answer questions such as identifying an appropriate Heatin

In networked control systems it is desirable to have efficient wireless communication (saving energy and bandwidth) while still ensuring good control performance. By abandoning periodic sampling, communication can be made more efficient by sampling and updating the control signal only "when required" based on the system’s behaviour. This is the concept of event-based control. In this work we consi

Children displaying early disruptive behaviour problems (DBP) in school are at risk for severe long-term problems. This study evaluated and compared a systemic school-based intervention, Marte Meo and Coordination meetings (MAC) with service as usual (SAU) in a randomised controlled trial. The teachers’ and parents’ ratings were collected before and after intervention. Target group were children a

The need for digital building information is increasing, both in the form of 3D city models (as geodata) and of more detailed building information models (BIM). BIM models are mainly used in the architecture, engineering and construction industry, but have recently become interesting also for municipalities. The overall aim of this paper is to study one way of dividing a building, namely the divis

An important question for video game research is how to characterize the video game experience. One common view emphasizes that players are cognitively able to operate with the game world as the experiential point of reference leading to states of "immersion, "spatial presence", or "engagement". A different view is that the player is also embodied and situated in the actual world, entailing that t