While the clinical importance of CD8+ and CD3+ cells in colorectal cancer (CRC) is well established, the impact of other immune cell subsets is less well described. We sought to provide a detailed overview of the immune landscape of CRC in the largest study to date in terms of patient numbers and in situ analyzed immune cell types. Tissue microarrays from 536 patients were stained using multiplexe

Syngas produced by gasification, which contains a high hydrogen content, has significant potential. The variation in the hydrogen content and dilution combustion are effective means to improve the steady combustion of syngas and reduce NOx emissions. OH planar laser-induced fluorescence technology (OH-PLIF) was applied in the present investigation of the turbulence of a premixed flame of syngas wi

We construct a three-Higgs doublet model with a flavour non-universal U(1) × ℤ2 symmetry. That symmetry induces suppressed flavour-changing interactions mediated by neutral scalars. New scalars with masses below the TeV scale can still successfully negotiate the constraints arising from flavour data. Such a model can thus encourage direct searches for extra Higgs bosons in the future collider expe

Background: There is an increased risk of suicidality in gambling disorder (GD) and economic hardship is common in the population. Economic hardship itself is a risk factor for suicidality. This study aims to explore the risk of intentional self-harm in GD utilizing social welfare payment (SWP) as a proxy for economic hardship and exploring how economic hardship, gender, criminality, socioeconomic

Objective: Schizophrenia, a complex psychiatric disorder, is often associated with cognitive, neurological and neuroim- aging abnormalities. The processes underlying these abnormalities, and whether a subset of people with schizophrenia have a neuroprogressive or neurodegenerative component to schizophrenia, remain largely unknown. Examining fluid biomarkers of diverse types of neuronal damage cou

Dokument har en central roll i det sociala arbetets vardag. När ord och siffror skrivs ner och därmed materialiseras går de att hänvisa till, inte bara för sitt innehåll utan också som dokument med en auktoritet i sin egen rätt. Socialarbetaren skapar mening genom att arbetsvardagen regisseras utifrån dokumenten.

In this paper, we study fundamental performance limitations of distributed feedback control in large-scale networked dynamical systems. Specifically, we address the question of whether dynamic feedback controllers perform better than static (memoryless) ones when subject to locality constraints. We consider distributed linear consensus and vehicular formation control problems modeled over toric la

In this article, we propose an optimisation framework that can contribute to the prevention of premature failure or damage to building structures and can thereby strengthen their longevity. We concentrate on structures that are contaminated by chemical substances and that have strong destructive effects on the material. The aim of this contribution is a mathematical algorithm that allows the optim

Introduction: Beyond total mesorectal excision (bTME) offers long-term survival in patients with advanced pelvic malignancy. At Skåne University Hospital (SUS) Malmö in Sweden, the vertical rectus abdominis musculocutaneous (VRAM) and gluteal maximus (GM) flap have been used for perineal reconstruction to promote healing and functional outcomes after significant tissue loss. This study aims to exa

Adult human cortical organotypic slice culture is an attractive model system to explore mechanisms of human brain pathology as well as to test drug candidates for treatment of neurodegeneration. Acute studies in human brain slices are limited by the lifetime of the tissue and focus mainly on hippocampus slice preparation. Here we describe the derivation of human organotypic slice cultures of corti

Anthropomorphic phantoms are models of real or virtual parts of the body, organ or tissue, represented by tissue-equivalent materials that aim to provide a realistic and accurate representation of their anatomy and properties. The aim of this study is to evaluate experimentally the suitability of 3D printed materials in the production of both, physical breast phantoms and abnormalities, to be used

Purpose: The research community has focused on defining reliable biomarkers for the early detection of the pathological hallmarks of Alzheimer’s disease (AD). In 2017, the Geneva AD Biomarker Roadmap initiative adapted the framework for the systematic validation of oncological biomarkers to AD, with the aim to accelerate their development and implementation in clinical practice. The aim of this wo

Tissue clearing allows 3D-imaging of large biomedical samples, but can be affected by blur effects limiting individual cells detection. Using a structured illumination light sheet we solve this issue, obtaining high-contrast images in turbid samples.

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