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Exocytosis in excitable cells is essential for their physiological functions. Although the exocytotic machinery controlling cellular secretion has been well investigated, the function of the vesicular cargo, i.e. secretory granular content remains obscure. Here we combine dSTORM imaging and single-domain insulin antibody, to dissect the in situ structure of insulin granule cores (IGCs) at nano lev

Introduction: Favourable joint outcomes are expected with modern haemophilia A (HA) management. Evaluation of long-term treatment outcomes is hampered by the delay between bleeding episodes during childhood and resulting joint outcomes in adulthood. Aim: To measure the long-term joint health of adolescents with moderate and severe HA, according to severity and inhibitor status. Methods: Pilot cros

In this work, planar two-photon laser-induced fluorescence (2p-LIF) is applied for the first time to analyze the fluid dependent spray structure and atomization behavior of water and ethanol in a quantitative way. A commercial six-hole DISI (Direct-Injection Spark-Ignition) injector was studied at different injection pressures, operated with liquids containing the LIF dye fluorescein. Specifically

Background: The global struggle against antibiotic resistance requires antimicrobial stewardship (AMS). Massive open online courses (MOOCs) offer health professionals unprecedented access to high-quality instructional material on AMS; the question is how apprehensible it is to non-native English speakers. Furthermore, to better understand how education interventions promote change towards rational

The main purpose of this thesis is to present a Cultural-Historical Activity Theory (CHAT) based analysis of the activities conducted by and with visually impaired users supported by audio-haptic technology.This thesis covers several studies conducted in two projects. The studies evaluate the use of audio-haptic technologies to support and/or mediate the activities of people with visual impairment

This practice-based PhD, Treating the Abstract of Capital Concretely:Films Against Capitalism, looks at how film can oppose the prevailing ideas of capitalist systems. The research asks: What qualities do films have that can be used asstrategies against capitalism and what knowledge do these films produce? In an understanding that capitalism projects concepts onto the world, and that mainstream fi

This report presents the assessment of a six-week online course offered by BeChange, which was given from April to June in 2022. Through a total of five online sessions, an interactive learning platform, diverse practices and individual coaching, the course aimed to support participants in reducing their CO2 emissions, increase their climate engagement, and at the same time enhance their wellbeing

Transparency is generally cited as a key consideration towards building Trustworthy AI. However, the concept of transparency is fragmented in AI research, often limited to transparency of the algorithm alone. While considerable attempts have been made to expand the scope beyond the algorithm, there has yet to be a holistic approach that includes not only the AI system, but also the user, and socie

In dual control, the manipulated variables are used to both regulate the system and identify unknown parameters. The joint probability distribution of the system state and the parameters is known as the hyperstate. The paper proposes a method to perform dual control using a deep reinforcement learning algorithm in combination with a neural network model trained to represent hyperstate transitions.

We investigate the impact of impurity configuration on electronic and optical properties of YVO4 through application of plane-wave DFT. Since this crystal is a common host material for optical devices and it has been widely used as a phosphor and a laser host material, it is important to identify a correlation between impurity location and the intrinsic properties of the material. To further impro

Following years of increasing bureaucracy and micro-management, there is a need for more trust in the judgement of street-level professionals and citizens in the public administration. After an intense debate in Sweden for several years, the Swedish Government launched a trust reform in 2016. This was organized around a government commission, called the Trust Commission. At the centre of its work

Demokratin kräver en fin väv av normer och strukturer för att kunna fungera. De fria allmänna valen är bara en del av många i denna väv. En annan del är starka och modiga professioner i det offentliga kärnuppdraget. Med sitt omdöme och sin professionella etik utgör dessa grupper en trygghet för våra medborgare och för deras talan i många situationer. Det finns flera skäl till att offentlig styrnin

Genom att öka handlingsutrymmet för medarbetarna i kärnuppdraget kan offentlig sektor bli mer effektiv och serviceinriktad. Grunden är en styrning som präglas av tillit och lyhördhet. Tillit är nödvändigt för att vårt samhälle ska stå starkt och för att statliga myndigheter, kommuner och regioner ska lyckas med sina uppdrag. Men hur bygger vi tilliten?I den här boken får du en introduktion till hu

OBJECTIVE: To investigate the influence of intravenous (iv) fluid volumes on the secretion of N-terminal-pro-brain natriuretic peptide (NT-Pro-BNP) in colorectal surgical patients and its association with cardiopulmonary complications (CPC). In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC. METHODS: Blood samples from patients enrolled in a previously p

Background Implementation in healthcare is often slow and poorly reported. Results include suboptimal outcomes and ad-verse consequences for patients. However, promising tools to remedy implementation speed and reporting already exist – such as the evidence-based, fast-track implementation model (Fast-IM) and the comprehensive RE-AIM (reach, effectiveness, adoption, implementation, and maintenance