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BACKGROUND AND OBJECTIVE: Bacillus Calmette-Guérin (BCG) reduces disease recurrence and progression in intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). BCG-associated adverse events during instillations are common, leading to treatment cessation. Prophylactic use of quinolones in conjunction with BCG instillations is one approach for reducing BCG-associated adverse events. O

The Danube fluvial terrace in Velika Vrbica is situated at the westernmost edge of the Wallachian basin, Serbia. The profile is positioned in a gully valley with a base consisting of point bar sands interlayered with overbank clay deposits, which are together covered by loess sediments. The investigated loess-paleosol sequence (LPS) has a height of 11.15 m and has been sampled at 5 cm intervals fo

Objective: The objective of this study was to compare health-related quality of life (HRQoL) and work productivity in axial SpA (axSpA) and non-axSpA patients with chronic back pain of <2 years. Methods: Baseline and 2-year data for patients included in the SPondyloArthritis Caught Early cohort were analysed. HRQoL was assessed by the physical (PCS) and mental component summary (MCS) scores of the

We demonstrate the existence of a first-order prewetting transition of a supracritical model polymer solution adjacent to an attractive surface. The model fluid we use mimics (qualitatively) an aqueous polyethylene oxide solution and, like the actual solution, displays a closed loop 2-phase region with an upper and lower critical solution temperature. The model fluid is shown to undergo a prewetti

Climate, forest successional stage, and soil substrate age can alter herbivore communities and their effects on biogeochemical cycling, but the size and spatial variability of these effects are poorly quantified. To address this knowledge gap, we established a globally distributed network of 50 broadleaved old-growth forests across six continents, encompassing well-constrained local-scale gradient

The study discussed in this article aimed to understanding how pre-activity formulations are designed and accomplished by mothers in play interactions as everyday interactional business. Here, we report specifically on instances during the lab-based interactions where the mother orients to the lab-based task of singing with their infant, and discuss potential implications of such participant orien

Iron is indispensable for the vast majority of organisms, and iron homeostasis plays a pivotal role in both the physiology and pathogenesis of fungal pathogens. However, the underlying mechanisms by which iron homeostasis modulates fungal pathogenesis remain to be fully elucidated. We therefore focused on investigating the functions of mitochondrial iron transporter ClMrs3/4 in virulence. We condu

Digital control systems introduce unavoidable computational latencies. For some controllers this time delay inhibits practical use, even though they in theory could provide more efficient control. For example, solving an optimization problem each sampling period when using model predictive control. By sampling faster than the computation time and executing independent controllers on distributed ha

Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highli

The 2024 Lund University Conference on Teaching and Learning, hosted by MedCUL and the Division for Higher Education Development (AHU), took place in the newly inaugurated Forum Medicum – an environment purposefully designed to inspire connection, collaboration, and exchange. The venue’s open architecture mirrored the conference theme, Connecting teachers – changing from within, underscoring the r

Future exposure to coastal flooding in China is driven more by growing populations and economic activity rather than by rising seas and intensifying storm surges. Policymakers must anticipate these multiple risk drivers to better inform spatial planning and development strategies and to ensure effective, sustainable coastal adaptation.

Balance functions have been regarded in the past as a method of investigating the late-stage hadronization found in the presence of a strongly-coupled medium. They are also used to constrain mechanisms of particle production in large and small collision systems. Charge balance functions for inclusive and identified particle pairs are reported as a function of charged particle multiplicity in proto

With two centuries of forestry, natural forests in boreal Swedenare rare and strongly fragmented. Hence, restoration aiming toimprove conditions for forest biodiversity is needed. However,to ensure landscape connectivity – where to restore is a criticalconcern.Our study objective was to identify connectivity forest thatthrough restoration support connectivity and biodiversity. Thestudy area coversWith two centuries of forestry, natural forests in boreal Sweden are rare and strongly fragmented. Hence, restoration aiming to improve conditions for forest biodiversity is needed. However, to ensure landscape connectivity – where to restore is a critical concern.Our study objective was to identify connectivity forest that through restoration support connectivity and biodiversity. The study area

The efficiency and stability of wide bandgap (WBG) perovskite solar cells (PSCs) are constrained by photo-induced halide segregation and severe non-radiative recombination, which significantly impedes the advancement of high-efficiency and stable perovskite/silicon tandem solar cells (PSTSCs). In this work, a potassium 4-sulfonic-1,8-naphthalic anhydride salt (4S-NAPS), featuring dual-anchoring si

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has a relapsing-remitting course and, even with the availability of effective maintenance therapies such as rituximab, relapse rates remain high. Relapse is associated with the accrual of organ damage stemming from both the underlying disease and from the effects of AAV treatments; thus, early detection and proactive prevention

In a previous paper, a comprehensive clinicopathologic approach to mild and moderate bleeding disorders (MBD) was proposed by an international working group (IWG) as a part of a project promoted by the European Hematology Association (EHA) on the development of guidelines on the various MBDs. A single pre-diagnosis grade 4 bleeding event according to the ISTH-BAT scale or a comparable event after

Vid de arkeologiska utgrävningarna av franciskankonventet på Lilla torg i Halmstad påträffades många gravar, däribland en man som hade fått ett stort svärd med sig i graven. Han låg begravd bredvid en kvinna och en yngling . I artikeln undersöks vem denne man kan ha varit, hans släktband och sociala omständigheter samt varför han begravts just på denna plats. De tre gravlagda kopplas till den dans

The interdisciplinary nature of microbiome research, coupled with the generation of complex multi-omics data, makes knowledge sharing challenging. The Strengthening the Organization and Reporting of Microbiome Studies (STORMS) guidelines provide a checklist for the reporting of study information, experimental design and analytical methods within a scientific manuscript on human microbiome research

The molecular pathways influencing the build-up of β-amyloid and tau pathology in Alzheimer's disease are unclear. To investigate how the involvement of different cell types influences β-amyloid and tau, we utilized single-cell RNA-seq data to derive cell-weighted polygenic risk scores. We included participants from the BioFINDER-1 study, including cognitively unimpaired (N = 734) individuals and