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An optimization study of an integrated periodic counter-current chromatography (PCC) process in a monoclonal antibody (mAb) downstream process at lab scale, is presented in this paper. The optimization was based on a mechanistic model of the breakthrough curve in the protein-A capture step. Productivity and resin utilization were the objective functions, while yield during the loading of the captu

In this work, we suggest a modified phase-field model for simulating the evolution of mixed mode fractures and compressive driven fractures in porous artificial rocks and Neapolitan Fine Grained Tuff. The numerical model has been calibrated using experimental observations of rock samples with a single saw cut under uniaxial plane strain compression. For the purpose of validation, results from the

Fibrosis is the result of dysregulated inflammation and tissue repair, and is characterized by the excessive accumulation of extra cellular matrix (ECM) proteins. It causes detrimental effects to the afflicted tissue and can subsequently lead to organ failure. Sterile liver inflammation and hepatic fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 in

A first step when fitting multilevel models to continuous responses is to explore the degree of clustering in the data. Researchers fit variance-component models and then report the proportion of variation in the response that is due to systematic differences between clusters. Equally they report the response correlation between units within a cluster. These statistics are popularly referred to as

Analys av amerikansk utrikespolitik vad gäller såväl isolationism som aktivt deltagande i världspolitiken i ett långt tidsperspektiv men med ett särskilt fokus på utvecklingen från millennieskiftet.

The effect of minimum wages on employment is a matter of debate, and the existing empirical literature contains mixed results. One reason for this is the methodological difficulties involved where changes in minimum wages are endogenous to other important economic changes. To overcome this problem, we examine exogenous changes to local minimum wages in Indonesia between 1989 and 1994. Our natural

When firms meet in multiple markets, they can leverage punishment ability in one market to sustain collusion in another. This is the first paper to test this theory for multiproduct retailers that sell consumer goods online. With data on the universe of consumer goods sold online in Sweden, I estimate that multimarket contact increases prices. To more closely investigate what drives the effect, I em

A negative association between socioeconomic status (SES) and divorce has been established for most Western nations after 1960, yet we know little about this relationship further back in time when divorce was rare. In low divorce contexts, we expect a positive association between SES and divorce because higher social strata are better equipped to overcome barriers to divorce. According to socioeco