Background: Speech impairments are an early feature of Alzheimer’s disease (AD) and consequently, analysing speech performance is a promising new digital biomarker for AD screening. Future clinical AD trials on disease modifying drugs will require a shift to very early identification of individuals at risk of dementia. Hence, digital markers of language and speech may offer a method for screening

An intrinsically phase-stable Sagnac interferometer is introduced for enhanced sensitivity detection in partially collinear two-dimensional spectroscopy. The sensitivity and phase accuracy of the apparatus are demonstrated on the dye IR-26 in the short-wave IR.

Metal-semiconductor hybrid nanostructures promise improved photoconductive performance due to plasmonic properties of the metal portions and intrinsic electric fields at the metal-semiconductor interface that possibly enhance charge separation. Here we report gold decorated CdSe nanowires as a novel functional material and investigate the influence of gold decoration on the lateral facets on the p

I denna studie undersöks organisationskulturens påverkan av en samhällskris inom ett medelstort svenskt företag, som likt många andra, fått genomlida coronapandemin. När ett digitaliserat distansarbete hastigt införs, och när medarbetare inte längre arbetar tillsammans som ett kollektiv på plats, kan organisationskulturen komma att hamna i skymundan. Vårt mål är att ta reda på hur pass hotad kultu

Context. The solar vicinity is currently populated by a mix of stars with various chemo-dynamic properties, including stars with a high metallicity compared to the Sun. Dynamical processes such as churning and blurring are expected to relocate such metal-rich stars from the inner Galaxy to the solar region. Aims. We report the identification of a set of old super-metal-rich (+0.15 ≤ [Fe/H] ≤ +0.50

Context. The high quality of the Gaia mission data has allowed for studies of the internal kinematics of the Large Magellanic Cloud (LMC) to be undertaken in unprecedented detail, providing insights into the non-axisymmetric structure of its disc. Recent works by the Gaia Collaboration have already made use of the excellent proper motions of Gaia DR2 and Gaia EDR3 for a first analysis of this sort

Background: Fibroblast-like synoviocytes (FLSs) are essential mediators in the expansive growth and invasiveness of rheumatoid synovitis, and patients with a fibroblastic-rich pauci-immune pathotype respond poorly to currently approved antirheumatic drugs. Galectin-9 (Gal-9) has been reported to directly modulate rheumatoid arthritis (RA) FLSs and to hold both pro- and anti-inflammatory properties

Denna uppsats studerar fallet Benny Fredriksson, en kulturprofil i Stockholm, som utsattes för ett kraftigt mediedrev, vilket i sin tur ledde till ett uppmärksammat självmord. Detta utspelade sig i ljuset av #metoo-rörelsen. Fokuset i uppsatsen kommer att ligga på frågan om ansvar. Med dagens digitaliserade nyhetsmedia utvecklas händelser snabbt till större mediedrev med många inblandade. Detta re

A monotone Boolean circuit is composed of OR gates, AND gates and input gates corresponding to the input variables and the Boolean constants. It is multilinear if for any AND gate the two input functions have no variable in common. We consider a generalization of monotone multilinear Boolean circuits to include monotone q-multilinear Boolean circuits. Roughly, a sufficient condition for the q-mult

In order to solve the problem of the uneven distribution of the flow and ammonia concentration field in the selective catalytic reduction (SCR) denitrification system of a 660 MW coal-fired power plant, a three-dimensional computational fluid dynamics (CFD) model was established at a scale of 1:1. The existing flow guide and ammonia fume mixing device were then calibrated and optimized. The relati

Maxillary growth inhibition in patients with cleft lip and palate (CLP) is an undesired effect that may occur in the teens despite proper primary care. Dental malocclusion and distortion of facial appearance can be treated with external distraction osteogenesis (DO) of the maxilla. This entails a Le Fort I osteotomy, fastening a semi-circular distractor to the skull, distraction for three weeks, a

Restvärme skapas i olika industriella processer och energin återvinns sällan. Detta beror till stor del på att investeringen i den teknik som omhändertar restvärmen samt infrastrukturen som är nödvändig för att sälja restvärmen kräver stora ekonomiska satsningar. I fjärde generationens fjärrvärme system kommer temperaturerna i nätet bli lägre vilket lättare möjliggör implementeringen av mer prisvä

Corporate net-zero emission pledges have multiplied in recent years, with estimates suggesting that more than 1000 companies have made such commitments. While seemingly indicative of companies stepping up to address climate change, critics have argued that pledges may be mere greenwashing if they rely on excessive offsetting and legitimise business-as-usual. Considerable grey and academic literatu

Spin–valley locking is ubiquitous among transition metal dichalcogenides with local or global inversion asymmetry, in turn stabilizing properties such as Ising superconductivity, and opening routes towards ‘valleytronics’. The underlying valley–spin splitting is set by spin–orbit coupling but can be tuned via the application of external magnetic fields or through proximity coupling. However, only