This paper addresses the main progresses and achievements of the H2020 STRATOFLY Project, funded by the European Commission, under the Horizon 2020 framework, specifically looking at the latest results in terms of environmental sustainability. In particular, starting from reporting the main environmental challenges posed by high-speed civil transportation, at local, regional and global levels, thi

BACKGROUND: Type 2 diabetes (T2D) has been reproducibly clustered into five subtypes based on six-clinical variables; age at diabetes onset, body mass index (BMI), Glutamic acid decarboxylase autoantibodies (GADA), glycated hemoglobin (HbA1c) and insulin secretion and resistance estimated as HOMA2B and HOMA2IR derived from fasting glucose and Cpeptide. These subtypes have different disease progr

There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D) and advanced atherosclerotic disease. We performed chromatin immunoprecipitation sequencing (ChIP-seq) using a histone 3 lysine 9 acetylation (H3K9ac) mark in peripheral blood mononuc

Low-Power Wide-Area Networks operating in the unlicensed bands are being deployed to connect a rapidly growing number of Internet-of-Things devices. While the unlicensed sub-GHz band offers favorable propagation for long-range connections, measurements show that the energy consumption of the nodes is still mostly dominated by the wireless transmission affecting their autonomy. We investigate the p

The exploitation of ultrafast electron dynamics in quantum cascade lasers (QCLs) holds enormous potential forintense, compact mode-locked terahertz (THz) sources, squeezed THz light, frequency mixers, and comb-basedmetrology systems. Yet the important sub-cycle dynamics have been notoriously difficult to access in operationalTHz QCLs. Here, we employ high-field THz pulses to perform the first ultr

Ex vivo manufactured red blood cells (RBC) generated from immortalized erythroid cell lines which can continuously grow are expected to become a significant alternative in future transfusion therapies. The ectopic expression of human papilloma virus (HPV) E6/E7 gene has successfully been employed to establish these cell lines. To induce differentiation and maturation of the immortalized cell lines

This paper aims at finding whether vaccination in childhood is an important source of improved health over the life cycle and across generations. We leverage high-quality individual-level data from Sweden covering the full life spans of three generations between 1790 and 2016 and a historical quasi-experiment – a smallpox vaccination campaign. To derive the causal impact of this campaign, we emplo

Learning which environmental cues that predict danger is crucial for survival and accomplished through Pavlovian fear conditioning. In humans and rodents alike, fear conditioning is amygdala-dependent and rests on similar neurocircuitry. Rodent studies have implicated a causative role for dopamine in the amygdala during fear memory formation, but the role of dopamine in aversive learning in humans

In-memory computing can be used to overcome the von Neumann bottleneck—the need to shuffle data between separate memory and computational units—and help improve computing performance. Co-integrated vertical transistor selectors (1T) and resistive memory elements (1R) in a 1T1R configuration offer advantages of scalability, speed and energy efficiency in current mass storage applications, and such

The integrated nature of the Sustainable Development Goals (SDGs) presents a challenge to implementing the 2030 Agenda. Analytical methods to support decision-makers are often developed without explicitly incorporating decision-makers’ views and experience. Here, we investigate whether existing methods are fit-for-purpose in supporting decision-makers at national and subnational levels. We identif

Familial, sequencing, and genome-wide association studies (GWASs) and genetic correlation analyses have progressively unraveled the shared or pleiotropic germline genetics of breast and ovarian cancer. In this study, we aimed to leverage this shared germline genetics to improve the power of transcriptome-wide association studies (TWASs) to identify candidate breast cancer and ovarian cancer suscep

Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak®) in multiple sclerosis (MS) patients. Methods: Litak® was offered to MS-patients irrespective of disease course. Litak® 10 mg was administered for 3–4 days during week 1. Based on lymphocyte count at week 4, patients received another 0–3 doses at week 5. A second course was administered 11 months later. Follow-up i

Purpose: To investigate how an artificial intelligence (AI) system performs at digital mammography (DM) from a screening population with ground truth defined by digital breast tomosynthesis (DBT), and whether AI could detect breast cancers at DM that had originally only been detected at DBT. Materials and Methods: In this secondary analysis of data from a prospective study, DM examinations from 14

In solitary insect pollinators such as butterflies, sensory systems must be adapted for multiple tasks, including nectar foraging, mate-finding, and locating host-plants. As a result, the energetic investments between sensory organs can vary at the intraspecific level and even among sexes. To date, little is known about how these investments are distributed between sensory systems and how it varie

MADS‐box transcription factors are crucial regulators of inflorescence and flower development in plants. Therefore, the recent interest in this family has received much attention in plant breeding programs due to their impact on plant development and inflorescence architecture. The aim of this study was to investigate the role of HvMADS‐box genes in lateral spikelet development in barley (Hordeum

Entangled logics, which attribute meaning to security, characterise the contemporary security field, bringing about broad comprehensions and ambiguous concepts. Civil defence has (re)surfaced as one such concept that is broadly conceived in the official discourses produced by decision-makers. Since security is ultimately enacted by practitioners, alias decision-takers, their interpretations of con

Post partum depression är ett omfattande folkhälsoproblem som utlandsfödda mödrar löper ökad risk att drabbas av. Rutinmässig screening av alla nyblivna mödrar för post partum depression har implementerats i många länder för att öka identifikationen, men tidigare forskning indikerar att hälso- och sjukvårdspersonal upplever screening av utlandsfödda mödrar som en svår arbetsuppgift. Det övergripanPostpartum depression is a major public health problem, which immigrant mothers are at particular risk of being affected by. Routine screening is implemented by many countries to increase identification, but research suggests that health care professionals experience screening of immigrant mothers as challenging. The overall aim of this thesis was therefore to develop an evidence-based educational

Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. Currently the only treatment for liver cirrhosis is liver transplantat