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Experimental evaluation of normal and shear delamination in cellulose-based materials using a cohesive zone model

An experimental study to characterize properties controlling delamination of paperboard is presented. The normal and shear traction–separation laws are measured and evaluated using a double cantilever beam (DCB) and a split double cantilever beam (SCB) specimen. The DCB-experiments provides normal separation data in good agreement with results using alternative experimental techniques. From the me

Immunomodulation therapy offers new molecular strategies to treat UTI

Innovative solutions are needed for the treatment of bacterial infections, and a range of antibacterial molecules have been explored as alternatives to antibiotics. A different approach is to investigate the immune system of the host for new ways of making the antibacterial defence more efficient. However, the immune system has a dual role as protector and cause of disease: in addition to being pr

Enforcement Powers of the United Nations Security Council : Enforcement Regimes for the Protection of Animals in Wartime

The United Nations Security Council has the authority to adopt binding decisions and to authorise military means to ensure international peace and security. Whereas the Security Council is not typically associated with animal protection, wildlife issues have become an international security concern. Wildlife poaching and trafficking of wildlife products finance criminal networks and armed groups.

Modeling Scientific Revolutions: Gärdenfors and Levi on the Nature of Paradigm Shifts

Gärdenfors' and Levi's theories of rational belief changes will be compared to Kuhn's theory of scientific progress. Gärdenfors' proposal to analyze scientific revolutions in terms of big changes in epistemic entrenchment will be criticized for not being able to represent the important constituting function of the paradigms. Parts of Levi's theory that are incompatible with Ku

Förhållandet mellan barns populära status, individuella bearbetningsstil och arbetsminneskapacitet

This study was conducted to investigate the relationship between perceived popularity, social information processing and working memory. With the intentions of examining popularity 209 (98 female, 111 male) children in second and fourth grade were presented with a roster of their classmates and were to nominate whom they liked and whom they disliked. To study working memory capacity a working memo

Vattensänkningar : en analys av orsaker och effekter

Populärvetenskaplig sammanfattning: Grässjön ligger på kommungränsen mellan Osby och Östra Göinge, och har varit utsatt för stora förändringar på 18- och 1900-talen, bl. a. sänkningsprojekt och ändrade flöden. Sjön ingår i Tommaboda/Ekeshultsån, som är en del av Skräbeåns avrinningssystem - en av de åar som rinner ut i Hanöbukten. Grässjön var före 1909 en del av den tills då mycket större VielånThere are records of lowering of the water level in a lot of the Swedish lakes from the middle of the 1700th century. The aim was gaining more areable land to meet the needs of more food to support the expanding population. In areas with top soil which contents of clay or loam as in the southwest of Scania in southern Sweden this was proven to be a successful way expanding the total outcome of the

Design and synthesis of novel 3-triazolyl-1-thiogalactosides as galectin-1, -3 and -8 inhibitors

Galectins are galactoside-binding proteins that play a role in various pathophysiological conditions, making them attractive targets in drug discovery. We have designed and synthesised a focused library of aromatic 3-triazolyl-1-thiogalactosides targeting their core site for binding of galactose and a subsite on its non-reducing side. Evaluation of their binding affinities for galectin-1, -3, and

Causality of anthropometric markers associated with polycystic ovarian syndrome : Findings of a Mendelian randomization study

Introduction Using body mass index (BMI) as a proxy, previous Mendelian randomization (MR) studies found total causal effects of general obesity on polycystic ovarian syndrome (PCOS). Hitherto, total and direct causal effects of general- and central obesity on PCOS have not been comprehensively analyzed. Objectives To investigate the causality of central- and general obesity on PCOS using surrogat

Prompt and non-prompt J/ψ production cross sections at midrapidity in proton-proton collisions at √s = 5.02 and 13 TeV

The production of J/ψ is measured at midrapidity (|y| < 0.9) in proton-proton collisions at s = 5.02 and 13 TeV, through the dielectron decay channel, using the ALICE detector at the Large Hadron Collider. The data sets used for the analyses correspond to integrated luminosities of Lint = 19.4 ± 0.4 nb−1 and Lint = 32.2 ± 0.5 nb−1 at s = 5.02 and 13 TeV, respectively. The fraction of non-prompt J/

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Oxidative DNA damage is recognized by 8-oxoguanine (8-oxoG) DNA glycosylase 1 (OGG1), which excises 8-oxoG, leaving a substrate for apurinic endonuclease 1 (APE1) and initiating repair. Here, we describe a small molecule (TH10785) that interacts with the phenylalanine-319 and glycine-42 amino acids of OGG1, increases the enzyme activity 10-fold, and generates a previously undescribed b,d-lyase enz

Drug survival of anti-TNF agents compared with vedolizumab as a second-line biological treatment in inflammatory bowel disease : results from nationwide Swedish registers

Background: Comparisons of second-line anti-tumour necrosis factor (TNF) agents and vedolizumab are sparse. Aim: To evaluate the effectiveness of anti-TNF agents compared to vedolizumab as second-line biologics in inflammatory bowel disease (IBD). Methods: A propensity score-matched cohort was created using Swedish nationwide registers. Patients with Crohn's disease or ulcerative colitis, exposed

The circumscription and phylogenetic position of Bryonora (Lecanoraceae, Ascomycota), with two additions to the genus

Lecanoraceae is one of the largest families of the Lecanoromycetes, with about 30 accepted genera, many of which, however, have uncertain status and/or circumscriptions. We assess the phylogenetic position of the genus Bryonora and its segregate Bryodina for the first time, using a six-locus phylogeny comprising the Lecanoraceae as well as closely related families. We find strong support for the p

Barnets bästa vid utmätning och exekutiv försäljning av bostäder i svensk utsökningsrätt

The subject of the present thesis is children’s rights in the process of debt collection. The main focus of the thesis is article 3.1 of Convention on the Rights of the Child (CRC) and its legal relevance in proportionality tests prior to decisions on seizure and sales of houses and apartments in Swedish insolvency law. The thesis is based on two studies. One legal dogmatic study on Swedish enforc

Enablement and empowerment among patients participating in a supported osteoarthritis self-management programme – a prospective observational study

Background: In Sweden, core treatment for osteoarthritis is offered through a Supported Osteoarthritis Self-Management Programme (SOASP), combining education and exercise to provide patients with coping strategies in self-managing the disease. The aim was to study enablement and empowerment among patients with osteoarthritis in the hip and/or knee participating in a SOASP. An additional aim was to

Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages

Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes G