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Strikes and local politics

Conflicts in the labour market are detrimental to economic growth and welfare. Sweden was among the countries with the highest incidents of industrial disputes in the 1920s, but experienced declining levels from the 1930s onward. Using Swedish data from 1919 to 1938, this column shows that towns with both powerful unions and strong Social Democratic presence experienced labour market peace. The re

Without coal in the age of steam and dams in the age of electricity : An explanation for the failure of Portugal to industrialize before the Second World War

We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War, based on a considerable body of contemporary sources. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for i

Economic Evaluation of Management of Dementia Patients - A Systematic Literature Review

Objective: The objective is to systematically review the literature on economic evaluations of the interventions for the management of dementia and Alzheimer patients in home, hospital or institutional care. Methods: A systematic search of published economic evaluation studies in English was conducted using specified key words in relevant databased and websites. Data extracted included methods and

Growth differentiation factor 15 is positively associated with incidence of diabetes mellitus : the Malmö Diet and Cancer–Cardiovascular Cohort

Aims/hypothesis: Growth differentiation factor 15 (GDF-15) is an anti-inflammatory cytokine of the transforming growth factor-β superfamily. Circulating levels of GDF-15 are associated with hyperglycaemia among people with obesity or diabetes, but longitudinal evidence on the association between GDF-15 levels and diabetes risk is scarce. Our aim was to explore whether circulating levels of GDF-15

Street-level priority-setting: The role of discretion in implementation of research, development, and innovation priorities

Research on priority-setting for research, development, and innovation (RDI) often does not take into account the many challenges associated with translating priorities into RDI programs and projects. Such implementation challenges are typically handled by RDI program officers at funding agencies i.e. those officers that manage RDI programs and projects. To address this challenge, this paper utili

Bayesian argumentation : The practical side of probability

Relevant to, and drawing from, a range of disciplines, the chapters in this collection show the diversity, and applicability, of research in Bayesian argumentation. Together, they form a challenge to philosophers versed in both the use and criticism of Bayesian models who have largely overlooked their potential in argumentation. Selected from contributions to a multidisciplinary workshop on the to

Bayesian argumentation : The practical side of probability

We give a brief introduction to the Bayesian approach to natural language argumentation, mainly oriented to readers more familiar with classical logic. Subsequently, we summarize the gist of each of the chapters so as to provide readers with an overview of the book&s content.

Farnesylated heat shock protein 40 is a component of membrane-bound RISC in Arabidopsis

ARGONAUTE1 (AGO1) binds directly to small regulatory RNA and is a key effector protein of post-transcriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA) in Arabidopsis. The formation of an RNA-induced silencing complex (RISC) of AGO1 and small RNA requires the function of the heat shock protein 70/90 chaperone system. Some functions of AGO1 occur in association

Estimating returns to hospital volume : Evidence from advanced cancer surgery

High-volume hospitals typically perform better than low-volume hospitals. In this paper, we study whether such patterns reflect a causal effect of case volume on patient outcomes. To this end, we exploit closures and openings of entire cancer clinics in Swedish hospitals which provides sharp and arguably exogenous variation in case volumes. Using detailed register data on more than 100,000 treatme

How frequency-dependent selection affects population fitness, maladaptation and evolutionary rescue

Frequency-dependent (FD) selection is a central process maintaining genetic variation and mediating evolution of population fitness. FD selection has attracted interest from researchers in a wide range of biological subdisciplines, including evolutionary genetics, behavioural ecology and, more recently, community ecology. However, the implications of frequency dependence for applied biological pro

Vad innebär valet i Armenien för ”Sammetsrevolutionen”?

Efter det fredliga regimskiftet under april 2018 var alla parter överens om att man behövde hålla tidiga val för att bättre återge den rådande allmänna opinionen i landet. Den 9 december höll man extra val som blev historiska i landets moderna historia, både i utförande men också utgång. Denna artikel ger bakgrund och en kort analys av valet och dess innebörd.

How best to support individuals with IDD as they become frail : Development of a consensus statement

Background: While higher rates and earlier onset of frailty have been reported among adults with intellectual and developmental disabilities (IDD), research on how best to support these individuals is lacking. Method: An international consultation relied on three consensus building methods: the Nominal Group Technique, an NIH consensus conference approach, and a Delphi survey. Results: There is ag

CGRP Antibodies as Prophylaxis in Migraine

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP liga