HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological diff

The Romance of the Forest (1791) secured Ann Radcliffe’s reputation as a writer of Gothic literature. The novel continued and expanded, as this chapter will show, the Walpolean tradition of re-evaluating the modern romance by injecting it with the virtues of “respectable” novels such as plausibility, mimetic acuity and Protestantism. After a brief recapitulation of Radcliffe’s theory of the supern

The covid-19 pandemic has necessitated reallocation of health care resources. This has raised concerns about the risks associated with postponing surgery for benign conditions that are given low priority. Data from the population-based Swedish National Register for Gallstone Surgery (GallRiks) show that the total number of procedures carried out during the initial months of each wave of the pandem

Computational models for predicting the early course of the COVID-19 pandemic played a central role in policy-making at regional and national levels. We performed a systematic review, data synthesis, and secondary validation of studies that reported on prediction models addressing the early stages of the COVID-19 pandemic in Sweden. A literature search in January 2021 based on the search triangle

A nursing programme in southern Sweden was revised to meet future demands. The aim of this study was to explore important conceptual areas to be included in a nursing programme in order to meet long-term societal and health care requirements. Group concept mapping (GCM), a mixed-methods approach, was used. Thirty-four experienced teachers participated. Data was collected during brainstorming sessi

TRAIN2WIND is a PhD TRAINing school analysing enTRAINment in offshore WIND farms with computer models and experiments. By its very nature, a wind turbine extracts energy from the wind, which is replenished from the wind field on the sides and above due to the ambient turbulence. However, offshore the turbulence is lower, and wind farms are typically larger than onshore, therefore the wind can only

The Eigenfactor™ is a journal metric, which was developed by Bergstrom and his colleagues at the University of Washington. They invented the Eigenfactor as a response to the criticism against the use of simple citation counts. The Eigenfactor makes use of the network structure of citations, i.e. citations between journals, and establishes the importance, influence or impact of a journal based on i

The Finnish Education Evaluation Centre has conducted an audit of Seinäjoki University of Applied Sciences and has awarded the university of applied sciences a quality label that is valid for six years from 14 April 2016. The quality management system of Seinäjoki University of Applied Sciences fulfils the national criteria set for the quality management of higher education institutions, and corre

A novel method using the cloud to implement a variable horizon model predictive controller is presented. In case of sudden long delays and downtime, a graceful degradation is used. Robust, best effort strategies allow industrial grade use of the powerful, efficient, and quickly improving cloud ecosystems. The variable horizon strategy finds use in, for example, non-linear control problems, and the

The orthodox definition of hope suffers from an exclusion problem: it is unable to exclude subjects without hope. In fact, the orthodox definition even allows for despair to be falsely classified as hope. This problem suggests two basic desiderata for a successful analysis of hope: it should solve the exclusion problem, and it should have the resources to explain why, in a given situation, a subje

In the promotion of energy efficiency in educational facilities, preschool children play an important role since simple energy-saving behaviour can be developed in early childhood. This study aimed to investigate the effects of behaviour interventions, with a particular focus on preschool children’s turn-off behaviour in shared environments. The intervention tools i.e. digital game, paper-board ga

This article examines the use of staged narratives in the Hogswatch celebration—a celebration of Terry Pratchett’s fictional Discworld held in November in Wincanton, Somerset. Different narratives are used in fandom as part of the process of qualia resituation, in which the what-it-is-like of the Discworld series is conveyed in the fandom celebration.

Objective: The objective of this study was to investigate the effect of tumor necrosis factor α inhibitor (TNFi) initiation on the use of antimicrobials among biologic-naïve patients with rheumatoid arthritis (RA). Methods: Information on all biologic-naïve patients with RA was extracted from ICEBIO, a nationwide registry. Each patient was matched on age, sex, and calendar time to five randomly se

OBJECTIVE: The aim of this multicentric registry was to assess the outcomes of "anteRior versus posteRior divisional bRanches Of the hYpogastric artery as distAl landing zone for iLiac branch devices (R3OYAL)."METHODS: The main exposure of interest for the purpose of this study was the internal iliac artery (IIA) divisional branch (anterior vs posterior) that was used as distal landing zone. Early