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Brain charts for the human lifespan

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morpho

Hunger effects on option quality for hedonic and utilitarian food products

Multiple studies have examined the extent to which consumers’ hunger levels predict their food choices and preference patterns. These investigations often involve making binary choices between hedonic foods (e.g., ice cream) that primarily serve to provide sensory pleasure, and utilitarian foods (e.g., bread) that mainly fulfill functional purposes. However, most consumers entering a grocery store

Decay studies in the A ∼ 225 Po-Fr region from the DESPEC campaign at GSI in 2021

The HISPEC-DESPEC collaboration aims at investigating the structure of exotic nuclei formed in fragmentation reactions with decay spectroscopy measurements, as part of the FAIR Phase-0 campaign at GSI. This paper reports on first results of an experiment performed in spring 2021, with a focus on β-decay studies in the Po-Fr nuclei in the 220 < A < 230 island of octupole deformation exploiting the

Fundamental effective temperature measurements for eclipsing binary stars-III. SPIRou near-infrared spectroscopy and CHEOPS photometry of the benchmark G0V star EBLM J0113+31

EBLM J0113+31 is a moderately bright (V = 10.1), metal-poor ([Fe/H] ≈-0.3) G0V star with a much fainter M dwarf companion on a wide, eccentric orbit (= 14.3 d). We have used near-infrared spectroscopy obtained with the SPIRou spectrograph to measure the semi-amplitude of the M dwarf's spectroscopic orbit, and high-precision photometry of the eclipse and transit from the CHEOPS and TESS space missi

Alpha-Amylase Inhibits Cell Proliferation and Glucose Uptake in Human Neuroblastoma Cell Lines

The present article describes a study of the effects of alpha-amylase (α-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. α-Amylase which is present in breast milk was shown to

Reduced order design and investigation of intakes for high speed propulsion systems

Ramjet propulsion is commonly preferred to power supersonic and hypersonic vehicles for cruising faster than Mach 3. This is an elegant solution owing to the lean architecture which does not embody any rotating parts. Although the geometry of the engine is simple as compared to turbine based configurations, the flow physics through the engine duct is quite complex and the flow speeds modulate betw

Reply to Paulius Bosas, Gintaras Zaleskis, and Dainius Characiejus's Letter to the Editor re : Sylvia H.J. Jochems, Josef Fritz, Christel Häggström, Bengt Järvholm, Pär Stattin, Tanja Stocks. Smoking and Risk of Prostate Cancer and Prostate Cancer Death: A Pooled Study. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2022.03.033. Therapeutic Monitoring in Prostate Cancer Should Involve a Cotinine Test in Current Smokers: Smoking Cessation Remains a Cornerstone in Preventive Health Care Overall and for Men with Prostate Cancer

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women

Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i)

Adapting the Queer Language of Anne Lister's Diaries

The Secret Diaries of Miss Anne Lister (2010) and Gentleman Jack (2019–2022) are both television dramas based on the private journals of Anne Lister (1791–1840). The diaries were not only partly written in code but make use of idiosyncratic terms, and the two adaptations deal in different ways with the language used in the diaries. This essay examines the language of Anne Lister’s diaries and comp

Hypertriton Production in p -Pb Collisions at sNN =5.02 TeV

The study of nuclei and antinuclei production has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. The first measurement of the production of HΛ3 in p-Pb collisions at sNN=5.02 TeV is presented in this Letter. Its production yield measured in the rapidity interval -1

Measurement of the nuclear modification factor for muons from charm and bottom hadrons in Pb+Pb collisions at 5.02 TeV with the ATLAS detector

Heavy-flavour hadron production provides information about the transport properties and microscopic structure of the quark–gluon plasma created in ultra-relativistic heavy-ion collisions. A measurement of the muons from semileptonic decays of charm and bottom hadrons produced in Pb+Pb and pp collisions at a nucleon–nucleon centre-of-mass energy of 5.02 TeV with the ATLAS detector at the Large Hadr

Prompt D0, D+, and D*+ production in Pb–Pb collisions at √sNN = 5.02 TeV

The production of prompt D0, D+, and D*+ mesons was measured at midrapidity (|y| < 0.5) in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair sNN = 5.02 TeV with the ALICE detector at the LHC. The D mesons were reconstructed via their hadronic decay channels and their production yields were measured in central (0–10%) and semicentral (30–50%) collisions. The measurement was per

Meristem Wall : An Exploration of 3d-printed Architecture

Meristem Wall is a prototype for a 3D-printed building envelope, featuring a dynamically controllable network of integrated air channels that allow a fl uid and adaptive relationship between inside and outside. The wall integrates functional lighting and electricity, windows, and a custom CNC-knitted textile interior. It is fabricated through binder-jet sand 3D printing and points towards a climat

Polygenic risk modeling for prediction of epithelial ovarian cancer risk

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could improve predictive performance over standard approaches of PRS construction. Here, we implemented computationally efficient, penalized, logistic regression models (lasso, elastic net, stepwise) to individ