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The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying processes. We conducted genome-wide studies of 1,916 plasma and urine metabolites and detected 1,299 significant associations. Associations with 40% of implicated metabolites would have been mi

BackgroundCongenic leptin receptor deficient rat generated by introgression of the Koletsky leptin receptor mutation into BioBreeding Diabetes Resistant rat (BBDR.lepr−/−) is a novel animal model combining obesity, systemic insulin resistance and diabetes. Systemic insulin resistance is associated with reduced myocardial glucose utilization, but its effect on myocardial external efficiency, i.e. t

Background & aims: Short telomeres have been observed in chronic disease patients. Identifying environmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 3

The reactions of [Fe2(CO)6(μ-sdt)] (1) (sdt = SCH2SCH2S) with phosphine ligands have been investigated. Treatment of 1 with dppm (bis(diphenylphosphino)methane) or dcpm (bis(dicyclohexylphosphino)methane) affords the diphosphine-bridged products [Fe2(CO)4(μ-sdt)(μ-dppm)] (2) and [Fe2(CO)4(μ-sdt)(μ-dcpm)] (3), respectively. The complex [Fe2(CO)4(μ-sdt)(κ2-dppv)] (4) with a chelating diphosphine was

In this chapter, the authors introduce the theme of computational/digital methods in the realm of sensory archaeologies. To this purpose, the concept of sensoriality and its relevance for the archaeological discourse is rediscussed. Key concepts such as perception of material culture help us in better defining possible modalities through which archaeologists can benefit from the use of formal meth

Conflictual cabinet terminations are seismic events in democracies, but their consequences are understudied. I argue that the electoral impacts of conflictual cabinet terminations depend on voters’ perceptions of them. Terminations following non-policy conflicts are electorally costly. They signal parties’ deteriorating governing competence, which reduces parties’ vote shares. In contrast, termina

Staging an open contest is a democratic method to choose a party leader, though its electoral consequences remain unclear. I argue that leadership contests are electorally detrimental to governing parties. Competitive contests signal intraparty policy and/or personality conflict to voters, which damages governing parties’ perceived unity as well as competence in the policy-making process. Thus, le

In this article, I argue that Westminster parliamentary systems encourage large opposition parties to replace their leaders between elections. Parliamentary system structures how parties compete over legislative outcomes. In Westminster systems, the government’s dominance in the legislative process promotes an adversarial government–opposition relationship. Subsequently, large opposition parties’

Smooth muscle cells (SMCs) are constituents of hollow inner organs. Their contractile function governs essential physiological functions, such as breathing, eating, blood pressure control, urination, and childbirth. Skeletal and cardiac muscle cells are terminally differentiated cell types, but SMCs are highly plastic and change their phenotype in disease. Cues presented by the microenvironment an

Why do mainstream opposition parties sometimes fail to adopt policy positions that are attractive to the wider electorate? In this paper, I construct a game-theoretic model between the party leader, the party’s MPs, and the party organization to illustrate how opposition parties’ platform adjustments depend on the party leader’s risk assessment of being deposed and MPs’ re-election incentives. The

Although classic voting studies noted that voters may reach their voting decision on the basis of different criteria most contemporary voting studies assume that one voting model fits all. Building on the limited, but developing literature on the topic, this paper develops and tests models incorporating voter decision criteria heterogeneity. Paying particular attention to the role of voter sophist

Despite coalition governments being the most widespread form of government, many aspects of coalition politics are still poorly understood. This is especially true for questions relating to the role of the prime minister party within the coalition. Being the prime minister party seems to imply considerable influence, but little evidence actually exists as to the factors shaping the influence of th

BACKGROUND: Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast and ovarian cancer (HBOC) has been attributed to PVs in the genes BRCA1 and BRCA2, and more recently other rare alleles have been firmly established as associated with a high or

The risk of breast cancer associated with CHEK2:c.1100delC is 2-threefold but higher in carriers with a family history of breast cancer than without, suggesting that other genetic loci in combination with CHEK2:c.1100delC confer an increased risk in a polygenic model. Part of the excess familial risk has been associated with common low-penetrance variants. This study aimed to identify genetic loci