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Automated detection of cell nuclei in fluorescence microscopy images is a key task in bioimage analysis. It is essential for most types of microscopy-based high-throughput drug and genomic screening and is often required in smaller scale experiments as well. To develop and evaluate algorithms and neural networks that perform instance or semantic segmentation for detecting nuclei, high quality anno
This article addresses the role of television as a ‘new media’ in government public relations. Drawing on sociological theories on informalisation, this study analyses three features of the Swedish public information programme Anslagstavlan during the 1970s and 1980s: first, formal techniques such as editing, pacing and use of animations; second, narrative strategies including the utilisation of c
Den psykiska ohälsan hos barn och unga i Sverige uppges öka över tid och är ett av vår tids största folkhälsoproblem. Men vad menas egentligen med psykisk ohälsa och hur har begreppet konstruerats inom den sociala barn- och ungdomsvårdens rättsliga normering? I den här rapporten visar författarna hur synen på psykisk ohälsa ges mening och förändras över tid i samspel med rådande samhällsnormer och
Den svenska fiskeflottan har krympt under lång tid och idag har mångafiskelägen endast ett fåtal fiskefartyg kvar. Även om yrkesfisket är enliten näring kan förlusten av fisket innebära att viktiga värden för lokalsamhället går förlorade. Ett sådant är att fisket lockar turister till hamnen. I den här rapporten analyseras fiskets betydelse för turismen isvenska fiskesamhällen. Detta görs genom två
This study focuses on the Swedish public information programme Anslagstavlan, a unique audiovisual communication tool for Swedish government agencies since 1972 and an important part of Sweden’s audiovisual cultural heritage. Whereas digital research methodologies for data-driven text analysis have been developed and established over the last decades, the use of digital tools in the analysis of au
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite nu
Many people and organizations across the globe work towards a sustainable future. Artificial intelligence (AI) can be a powerful tool in their efforts.AI technologies, which aim to imitate the natural intelligence of humans and animals, have made enormous progress in the past decade. AI has brought us a whole range of futuristic tools — from self-driving cars to virtual assistants, smart home appl
Background: There are indications that early-life exposure to perfluoroalkyl substances (PFAS) can impact neurodevelopment, but results are inconclusive. The objective was to investigate if high early-life exposure to primarily perfluorohexanesulfonic acid (PFHxS) and perfluorooctanesulfonic acid (PFOS) increases the risk of developmental language disorder in children up to seven years of age.Meth
We are surrounded by various chemicals, both naturally occurring and synthetically produced. Some, but not all, chemicals can be hazardous for human health following exposure, especially for vulnerable population groups including children, adolescents, and pregnant women. The increased use and production of chemicals have contributed positively to society in numerous ways, while also resulting in
Uncharacterized side activities of enzymes can have significant effects on reaction products and yields. Hence, their identification and characterization are crucial for the development of successful reaction systems. Here, we report the presence of feruloyl esterase activity in CtXyn5A from Acetivibrio thermocellus, besides its well-known arabinoxylanase activity, for the first time. Activity ana
The enzymatic depolymerization of synthetic polyesters has become of great interest in recycling plastics. Most of the research in this area focuses on the depolymerization of polyethylene terephthalate (PET) due to its widespread use in various applications. However, the enzymatic activity on other commercial polyesters is less frequently investigated. Therefore, AkestraTM attracted our attention
Astrocytes are one of the major cell types in the central nervous system and are indispensable for brain development and function. The human brain and human astrocytes have unique structures and functions that are not present in other animal species. Studies of fundamental astrocyte biology in humans and their role in neurological disease have been hindered by shortage of native human astrocytes f
Individuals with a family history of colorectal cancer (CRC) are at a high risk of developing CRC. Preclinical and population-based evidence suggests that selective serotonin reuptake inhibitors (SSRIs) might play a role in preventing CRC. We performed a nationwide cohort study to explore whether the use of SSRIs could reduce CRC risk among individuals with family history. We identified individual
A hot-carrier solar cell aims to generate power from energetic, photoexcited, charge carriers, so called hot carriers, in order to reach higher conversion efficiencies than current solar cell technology.Creating a hot-carrier solar cell has proven challenging for two main reasons: hot carriers lose their energy very quickly, and they need to be extracted over distances of a few hundrednanometers v
Poly(xanthene)s (PXs) carrying trimethyl ammonium, methylpiperidinium and quinuclidinium cations were synthesized and studied as a new class of anion exchange membranes (AEMs). The polymers were prepared in a superacid-mediated polyhydroxyalkylation involving 4,4’-biphenol and 1-bromo-3-(trifluoroacetylphenyl)-propane, followed by quaternization reactions with the corresponding amines. The archite
Since the founding of the field of Western esotericism, The Theosophical Society has been counted among the more obvious cases of the field's objects of study, regardless of how "Western esotericism" itself has been defined. This paper explores the connection between Western esotericism as a research field, esotericism as its object of study, and the Theosophical Society as an example of esoterici
The aim of the present paper is to explore the interrelated and complex relationships between religionsvetenskap (Religious Studies), religionskunskap (Religious Education) and religionsdidaktik (Religion and Education). After briefly outlining the concurrent developments of Religious Studies as a university discipline and Religion and Eudcation as a non-confessional school subject, both of which
Key points• Obsessive-compulsive disorder is a disabling mental disorder with a lifetime prevalence of around 2% with similar rates across age groups and countries.• Diagnosis is made based on a pattern of time-consuming, clinically distressing, or impairing obsessions and compulsions and most cases emerge during puberty or early adulthood.• Obsessions are recurrent, persistent, and intrus
