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Phase II Study of the Human Anti-Epithelial Cell Adhesion Molecule Antibody Adecatumumab in Prostate Cancer Patients with Increasing Serum Levels of Prostate-Specific Antigen after Radical Prostatectomy

Background: Rising serum levels of prostate-specific antigen (PSA) after radical prostatectomy are indicative of recurrent prostate cancer. This double-blind, placebo-controlled phase II study evaluated the anti-tumour activity of the anti-epithelial cell adhesion molecule (EpCAM) antibody adecatumumab in delaying biochemical disease progression. Patients and Methods: Prostate cancer patients with

Effective dose from chest tomosynthesis in children.

Tomosynthesis (digital tomography) is a recently introduced low-dose alternative to CT in the evaluation of the lungs in patients with cystic fibrosis and pulmonary nodules. Previous studies have reported an adult effective dose of 0.12-0.13 mSv for chest tomosynthesis. The aim of this study was to determine the paediatric effective dose from the dose-area-product. During a 3-y period, 38 children

The Intergenerational Transmission of Schooling: Are Mothers Really Less Important than Fathers?

There is a “puzzle” in the literature on the intergenerational transmission of schooling, where twin studies emphasize the importance of fathers’ schooling, whereas IV-studies often emphasize the importance of mothers. We provide new evidence on this “puzzle” using register based Swedish data on the largest sample of twins used so far in the literature. In contrast to previous twin studies, our re

Search for contact interactions and large extra dimensions in dilepton events from pp collisions at root s=7 TeV with the ATLAS detector

A search for nonresonant new phenomena, originating from either contact interactions or large extra spatial dimensions, has been carried out using events with two isolated electrons or muons. These events, produced at the LHC in proton-proton collisions at root s = 7 TeV, were recorded by the ATLAS detector. The data sample, collected throughout 2011, corresponds to an integrated luminosity of 4.9

Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types.

BACKGROUND: Serology for human papillomaviruses (HPV) types -16 and -18 is established as an important tool for studies of HPV vaccinology and epidemiology. However, as there are a large number of oncogenic genital types of HPV there is a need for development of high-throughput, validated HPV serological assays that can be used for more comprehensive seroepidemiological studies and for research on

Simultaneous Visualization of Water and Hydrogen Peroxide Vapor Using Two-Photon Laser-Induced Fluorescence and Photofragmentation Laser-Induced Fluorescence

A concept based on a combination of photofragmentation laser-induced fluorescence (PF-LIF) and two-photon laser-induced fluorescence (LIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor. Water detection is based on two-photon excitation by an injection-locked krypton fluoride (KrF) excimer laser (248.28 nm), which induces broadband f

Early stages of spinodal decomposition in Fe-Cr resolved by in-situ small-angle neutron scattering

In-situ, time-resolved small-angle neutron scattering (SANS) investigations of the early stages of the spinodal decomposition process in Fe-35Cr were performed at 773 and 798K. The kinetics of the decomposition, both in terms of characteristic distance and peak intensity, followed a power-law behaviour from the start of the heat treatment (a' = 0.10-0.11 and a '' = 0.67-0.86). Furthermore, the met

Surgical Care and Health Systems

BACKGROUND: While surgical care impacts a wide variety of diseases and conditions with non-operative and operative services, both preventive and curative, there has been little discussion concerning how surgery might be integrated within the health system of a low and middle-income country (LMIC), nor how strengthening surgical services may improve health systems and population health. METHODS: We

Parameter space mapping of InAs nanowire crystal structure

Crystal structure and defects have been shown to have a strong impact on III-V nanowire properties. Recently, it was demonstrated that the issue of random stacking and polytypism in semiconductor nanowires can often be controlled using accessible growth parameters (such as temperature, diameter, and V/III ratio). In addition, it has been shown that crystal phase can be tuned selectively between cu

Anisotropic electric fluctuations in polar liquids under spherical confinement

The anisotropic local electric fluctuations within a nanoscopic sphere of a polar fluid surrounded by vacuum are analysed using dielectric theory and molecular simulation. The electric fluctuations are characterized through the mean-square multipole moments (Q(l)(2)), which are related to the dielectric constant of the fluid. The results show that the fluctuations are suppressed close to the fluid

SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma - a Nordic Lymphoma Group study.

Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enable stratification of the clinical diverse MCL patients into three risk groups. So

Psychometric properties of the Tampa Scale of Kinesiophobia (TSK-11) among older people with chronic pain.

Abstract Objectives: The study aimed to test the construct validity, factor structure and reliability of the 11-item version of the Tampa Scale for Kinesiophobia (TSK-11, Swedish version) among older people (65+) with chronic pain. Design: Methodological study. Subjects: 433 participants with chronic pain (mean age 74.8, 65-98 years) completed postal questionnaires. 264 of the participants complet

Prospective observational cohort studies for studying rare diseases: the European PedNet Haemophilia Registry

Haemophilia is a rare disease. To improve knowledge, prospective studies of large numbers of subjects are needed. To establish a large well-documented birth cohort of patients with haemophilia enabling studies on early presentation, side effects and outcome of treatment. Twenty-one haemophilia treatment centres have been collecting data on all children with haemophilia with FVIII/IX levels up to 2

Low-Rank Second-Order Splitting of Large-Scale Differential Riccati Equations

We apply first- and second-order splitting schemes to the differential Riccati equation. Such equations are very important in e.g. linear quadratic regulator (LQR) problems, where they provide a link between the state of the system and the optimal input. The methods can also be extended to generalized Riccati equations, e.g. arising from LQR problems given in implicit form. In contrast to previous

A Minimal Solution to Relative Pose with Unknown Focal Length and Radial Distortion

In this paper, we study the minimal problem of estimating the essential matrix between two cameras with constant but unknown focal length and radial distortion. This problem is of both theoretical and practical interest and it has not been solved previously. We have derived a fast and stable polynomial solver based on Gr{\"o}bner basis method. This solver enables simultaneous auto-calibration of f

Inverse modelling of European N2O emissions: assimilating observations from different networks

We describe the setup and first results of an inverse modelling system for atmospheric N2O, based on a four-dimensional variational (4DVAR) technique and the atmospheric transport zoom model TM5. We focus in this study on the European domain, utilizing a comprehensive set of quasi-continuous measurements over Europe, complemented by N2O measurements from the Earth System Research Laboratory of the

Second Thoughts on Free Riding

We use the strategy method to classify subjects into cooperator types in a large-scale online Public Goods Game and find that free riders spend more time on making their decisions than conditional cooperators and other cooperator types. This result is robust to reversing the framing of the game and is not driven by free riders lacking cognitive ability, confusion, or natural swiftness in respondin