Hur ser vår inre NuRD ut? NuRD är ett molekylkomplex som arbetar med att slå på och av gener i vårt DNA. Man har upptäckt att NuRD ibland stänger av gener som normalt verkar för att hämma cancer. Om man kunde ta reda på den exakta strukturen av NuRD så skulle man kunna designa läkemedel som hindrar NuRD från att stänga av våra naturliga cancerhämmare. Vår arvsmassa är samlad som en kod i en värThe Nucleosome Remodeling and Deacetylase (NuRD) complex is a transcriptional regulator essential to several normal developmental processes, but also found to have a role in several types of cancer. In order to design cancer therapies targeting this complex, determining the structure and subunit composition is crucial. X-ray crystallography is required for the level of detail desired, demanding la

In current experiments at the high-power laser facility at the Lund Laser Centre, electrons accelerated to hundreds of MeV over short distances by means of laser wakefield acceleration in produced plasmas. To determine the amount of secondary radiation generated when accelerated electrons interact with surrounding materials is of interest to ensure a safe working environment. In this thesis, the

Bimodal harmonic structured (HS) materials, is a new class of multi-scale architected metallic materials having specified topological arrangement of coarse- and ultra-fine grains. HS are experimentally proven to combine both high strength and ductility associated with ultra-fine- and coarse-grained fractions respectively. In this work, finite-element models of HS structured specimens were construc

Protected areas (PAs) embody a historical legacy of value contestation and human exclusion. While the rise of community-based conservation in the 1980s sought to reconfigure this mechanism by running a counter narrative arguing that biodiversity conservation and development were mutually reinforcing objectives, exclusionary PAs continue to maintain a strong position in the conservation discourse.

The Amazon has always been a strategic region because of its rich variety in natural resources. Its global interest is spreading across levels and scales, influenced by the increasing demand for fossil fuels and biodiesel and the threat of climate change. Neoliberal practices continue privatizing and exploiting the Amazon´s resources regardless the Indigenous communities’ interests. These communit

This report discusses two research questions concerning ocular dominance columns, a cortical structure present in the primary visual cortex which predominately respond to either left or right eye stimuli. The first research question addresses the problem of retinotopy and ocular dominance columns. Retinotopy is the mapping of visual stimuli in the retina to a location in the visual cortex. Current

Vid värmeåtervinning från gråvatten nyttjas spillvärme som annars skulle gått förlorad från stadens infrastruktur. Gråvatten är avloppsvatten från bad, disk och tvätt. Utav hushållsavloppsvattnets totala kemiska och termiska energi finns 80 % lagrad i gråvattnet i form av värme. Genom att källsortera avloppsvatten kan värmeenergin i gråvattnet utnyttjas samtidigt som andra åtgärder med ekologiska

This is the story if a beginning, a beginning of a journey to the unknown, to find my own path, because paths are made by walking...but you have to do the scariest part: start to walk. The project is presented as a handbook for the next generations of students that want to start their own office, answering the same questions and difficulties that I had during my trip. The idea of this Master pro

Previous studies have entertained the prospect of having 3D models substitute for their dry bone originals in osteological analysis. The objective of this study was to contribute to qualifying to what extent this may be possible given current technology. To this purpose, rather than choosing just a quantitative and purely technical method for evaluating models, as has been the norm in previous stu

The blogosphere recently experiences an increasing attention by PR practice which engages in blogger relations to target bloggers as influential online gate-keepers. Bloggers thereby are given numerous possibilities to make use of their authenticity and credibility, and endorse brands through collaborations with PR. This study explores the established discipline of blogger relations in German PR a

The aim for this thesis is to find out what aspects are important to create a good sound environment at home. In order to do this three different sound environments has been studied in the literature review: hospitals, schools/pre-schools and offices. Important acoustical parameters was picked out and a method for evaluating the sound environment at home was carried out. The main subject was to fi

Soils provide the foundation for human well-being but are increasingly degrading from land use change or types of intensive land use like agriculture. In Europe, soil natural capital is degrading over time and space because of compaction, erosion, and the loss of organic matter. This trend diminishes the soil’s ability to sustain a flow of ecosystem services, which are valuable to human well-being

Arbetet undersöker utvalda råvarufutres möjlighet att genom en cross-hedge prissäkra Dried Distillers Grain with Solubles (DDGS) som är en biprodukt från etanoltillverkning. Processen för att finna den bästa cross-hedgen sker genom OLS, ECM, VECM och MIDAS regressioner med både in sample estimeringar och out of sample prognostiseringar. Regressionerna använder börshandlade råvarufutures och säljpr

Since good cameras are becoming cheaper and embedded systems are getting more powerful, using cameras as the only sensor is getting more popular for visual navigation of robots. By using a robot to explore a flat surface a map can be gradually generated using the images taken by a downward looking camera. The thesis focus lies primarily on offline map building, where complete datasets are first ga

Gram-positive bacteria e.g. Streptomyces coelicolor [8], Bacillus subtilis [43] and Staphylococcus aureus [40] contain a novel sensor for the nicotinamide adenine dinucleotide (NAD) redox balance that functions as a transcriptional repressor called Rex (redox). Rex plays a key role in regulating genes in energy metabolism. It also modulates transcription of important genes for cellular redox homeo

Freezing is a method used to preserve food for long periods of time by reducing the rate of naturally occurring reactions and growth of microorganisms. However, some irreversible quality changes, both physical and chemical, can take place during the freezing step. After being frozen, the products are stored until thawed and consumed. This thesis studies innovative freezing technologies to understa

Food infant composite meals are complex-based products for infants and toddlers (6-36 months of age). There are a wide variety of infant food dishes available in the market based on different technologies with different flavors, tastes and preferences. During the last 40 years the number of obese children have increased and at the same time there is an increase in diabetes in areas where toddlers

This thesis discusses whether wage convergence has taken place between six countries in the Association of the Southeast Asian Nation (ASEAN) from the time between 2000 and 2014. The countries included are Singapore, Indonesia, Malaysia, Philippines, Thailand and Vietnam. Following the approach by Stehrer and Wörz (2003), a fixed-effects model which uses initial wage gap to a reference country (th