Highly dimensional single cell analysis of peripheral inflammation in ALS with mass cytometry
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neither a known cause nor an available cure. With disease progression, toxic protein aggregates form in the brain, leading to the loss of the upper and lower motor neurons. While circulating bone marrow-derived inflammatory cells have not been shown to cross the blood brain barrier, changes in their number and comp
