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Acute pancreatitis–can evidence-based guidelines be transferred to an optimized comprehensive treatment program?
Acute pancreatitis is a common cause of hospitalization and has an incidence of about 300 per 1,000,000 inhabitants. A majority of patients with acute pancreatitis have mild disease, with an absence of local and systemic complications [1]. The clinical, translational, and experimental research in the field of acute pancreatitis is enormous and various guidelines exist. The guidelines have improved
Local biomarkers involved in the interplay between obesity and breast cancer
Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non‐melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abundant in the breast. There-fore, breast cancer develops in an adipose‐rich environment. During obesity, changes in the local environment in the breast
Exploring meal frequency and vegetable intake among immigrants 70 years or older in Sweden : Secondary analysis of data from the Promoting Aging Migrants Capabilities study
Background: Earlier research regarding immigrants has shown that lifestyle and environmental factors are of importance for the risk of developing certain diseases. Food habits are one of these factors. As there is little research concerning immigrants and food habits, the aim of the present paper was to explore food habits operationalised as meal frequency and vegetable intake among a group of old
The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility
Placental malaria infection is mediated by the binding of the malarial VAR2CSA protein to the placental glycosaminoglycan, chondroitin sulfate. Recombinant subfragments of VAR2CSA (rVAR2) have also been shown to bind specifically and with high affinity to cancer cells and tissues, suggesting the presence of a shared type of oncofetal chondroitin sulfate (ofCS) in the placenta and in tumors. Howeve
Towards enhancing the versatility of the lignin biorefinery: Insights into batch and continuous mode depolymerisation processes
CRISPR editing of the PPARGC1A Gly482ser (rs8192678) polymorphism in human white adipose cells shows differential effects on mitochondrial function and adipogenesis.
Background and aims: PPARGC1A encodes PGC-1α (peroxisome proliferator-activated receptor γ coactivator 1-α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipoc
Oxidative Depolymerisation of Lignosulphonate Lignin into Low-Molecular-Weight Products: A Catalyst Screening Study
Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles
BACKGROUND: Diesel engine exhaust causes adverse health effects. Meanwhile, the impact of renewable diesel exhaust, such as hydrotreated vegetable oil (HVO), on human health is less known. Nineteen healthy volunteers were exposed to HVO exhaust for 3 h in a chamber with a double-blind, randomized setup. Exposure scenarios comprised of HVO exhaust from two modern non-road vehicles with 1) no aftert
The introduction and experiences of methadone for treatment of cancer pain at a low-resource governmental cancer center in india
Objectives: This study aimed to describe the clinical experience of the health-care professionals (HCPs) responsible for the introduction of methadone, for the treatment of complex cancer pain, at a low-resource hospital in India in a patient-group, burdened by illiteracy, and low socio-economic status. Materials and Methods: Ten HCPs: Four medical doctors, four nurses, one pharmacist, and one hos
Explaining prevalence, diversity and host specificity in a community of avian haemosporidian parasites
Many hypotheses attempt to explain parasite–host associations, but rarely are they examined together in a single community. For hosts, key traits are the proportion of infected individuals (prevalence) and the diversity of parasites infecting them. A key parasite trait is host specificity, ranging from specialists infecting one or a few closely related species to generalists infecting many species
An extended charge-current formulation of the electromagnetic transmission problem
A boundary integral equation formulation is presented for the electromagnetic transmission problem where an incident electromagnetic wave is scattered from a bounded dielectric object. The formulation provides unique solutions for all wavenumbers in the closed upper half-plane belonging to argument sets for which Maxwell's equations have unique solutions. This includes the challenging combination
The benefits of help in cooperative birds : Nonexistent or difficult to detect?
In birds that breed cooperatively in family groups, adult offspring often delay dispersal to assist the breeding pair in raising their young. Kin selection is thought to play an important role in the evolution of this breeding system. However, evidence supporting the underlying assumption that helpers increase the reproductive success of breeders is inconsistent. In 10 out of 19 species where the
Evacuation elevators in an underground metro station : A Virtual Reality evacuation experiment
The number of underground metro stations around the world is steadily increasing and deep stations are becoming more common. Evacuation elevators can be a way to mitigate many of the evacuation problems of deep stations, e.g., fatigue. However, the elevators need to be used by evacuees to be effective. In order to study the influence of evacuation measures on elevator usage, experiments were perfo
Bladder cancer therapy without toxicity—A dose-escalation study of alpha1-oleate
Potent chemotherapeutic agents are required to counteract the aggressive behavior of cancer cells and patients often experience severe side effects, due to tissue toxicity. Our study addresses if a better balance between efficacy and toxicity can be attained using the tumoricidal complex alpha1-oleate, formed by a synthetic, alpha-helical peptide comprising the N-terminal 39 amino acids of alpha-l
Mineral composition of drinking water and daily uptake
Conductivity gives a rough idea of the amount of dissolved ions in water (mS/m) or (µS/cm). Distilled water is
Procrastination, Affective State, Rumination, and Sleep Quality : Investigating Reciprocal Effects with Ambulatory Assessment
Procrastination is a prevalent problem among university students and associated with high long-term costs, but the short-term antecedents and consequences of procrastination are not well understood. Some related negative outcomes could be consequences as well as predictors of procrastination. The aim of the present study was to investigate possible reciprocal associations of affective, cognitive a
Evaluation of integration of sustainable development in higher education in Sweden
Purpose: Since 2006, higher education institutions (HEIs) in Sweden, should according to the Higher Education Act, promote sustainable development (SD). In 2016, the Swedish Government asked the Swedish higher education authority to evaluate how this study is proceeding. The authority chose to focus on education. This paper aims to produce a report on this evaluation. Design/methodology/approach:
Western Marsh Harriers Circus aeruginosus from nearby breeding areas migrate along comparable loops, but on contrasting schedules in the West African–Eurasian flyway
Much of our knowledge about migratory behaviour comes from single-population tracking studies. Some such studies had a considerable impact on migration research at large. However, it is often unclear how representative such studies are for other populations, even of the same species. We compared migration corridors and schedules of GPS-tracked adult Western Marsh Harriers (Circus aeruginosus) from
A virtual reality study of behavioral sequences in residential fires
Decision-making in residential fires can be difficult to study in an experimental setup. Virtual reality could be a way to expose participants to a residential fire scenario and collect data on their behavior. However, the validity of the data obtained needs to be assessed. To explore that, the data collected in two virtual reality residential fire scenarios in form of sequences of behavior was co