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MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA expression due to glycemic status, which could contribute to the development of type 2 diabetes (T2D). To this end, miRNAs were identified by a combinatio
This article introduces the concept of the exit spiral to conceptualize processes in which poorly functioning hospital clinics or wards enter a phase of decline due to widespread dissatisfaction among staff, prompting turnover contagion. In describing and analyzing cases amassed during observations and interviews, the article provides tools to identify, analyze and halt exit spirals. Once a hospit
Industrialization brought significant economic and social changes. As a response to the risk of income loss due to illness and workplace accidents, mutual health insurance was the main financial vehicle for workers at the turn of the twentieth century across the Western world. We studied individual and firm-level determinants of membership in health insurance societies among male workers in Swedis
The last twenty years have brought about a significant increase in the awareness of war practices that harm women, including rape and sexual abuse. However, focusing on women alone is not sufficient if gendered and racialised power hierarchies in the civilian and military worlds are to be understood. Experiences from international peacekeeping since 2000 foreground the need for an intersectional l
Resistance to Russia’s aggression is being shaped by how decentralised and data-centric global rules have become.
The Swedish Hernia Register (SHR) is a national quality register with more than 350,000 prospectively registered groin hernia repairs. Studies from the SHR have addressed important and clinically relevant issues within the field of laparoscopic groin hernia surgery and the aim of this paper is to present five of the most innovative patient-oriented publications including analysis of laparoscopic h
To show the impact of interviews for European legal studies, this article summarizes the earlier findings of two books, the first by Arold on the legal culture of the European Court of Human Rights (ECtHR), and the second by Arold Lorenz, Groussot and Petursson on the legal culture of the European Court of Justice (CJEU) and European human rights culture. In doing so, this article draws a portrait
This paper describes a method to minimize bearing forces as well as bearing and housing mass for a multistage gear reduction. This is done by finding the optimum dog-leg angles for the stages while leaving other aspects of the design unaltered. The optimization is demonstrated first for spur gears, and then for helical gears typically used in electric vehicles. A numerical example shows how bearin
Introduction: Many studies have assessed the prevalence of alcohol consumption in Iran. In this study, we investigated the prevalence of alcohol consumption in different groups. Material and Methods: We searched international and databases including PubMed, Web of Science, Scopus and we searched two main Farsi-language index databases including Scientific Information Database (SID) and the Irandoc
Age-related macular degeneration (ARMD) is one of the most debilitating eye-related illnesses worldwide. Eye-movement training is evolving to be a non-invasive, rapid, and effective method that is positively impacting vision and QoL (quality of life) in patients suffering from ARMD. This review aims to highlight why a greater adoption of eye-movement training in the clinical and research setting i
Stroke is the second leading cause of death and the third leading cause of disability worldwide and its burden is increasing rapidly in low-income and middle-income countries, many of which are unable to face the challenges it imposes. In this Health Policy paper on primary stroke prevention, we provide an overview of the current situation regarding primary prevention services, estimate the cost o
Early March 2022 saw the fifth United Nations Environment Assembly (UNEA) in Nairobi, Kenya. The UNEA is the highest-level international decision-making body on the environment, gathering delegates from 175 UN member countries to set shared goals and coordinate policy on global environmental issues. In a remarkable achievement, governments agreed at UNEA on a resolution to launch negotiations on a
