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Assembly mechanisms of the bacterial cytoskeletal protein FilP

Despite low-sequence homology, the intermediate filament (IF)-like protein FilP from Streptomyces coelicolor displays structural and biochemical similarities to the metazoan nuclear IF lamin. FilP, like IF proteins, is composed of central coiled-coil domains interrupted by short linkers and flanked by head and tail domains. FilP polymerizes into repetitive filament bundles with paracrystalline pro

Tailored emission to boost open-circuit voltage in solar cells

Recently, a lot of research focus has been on how to make solar cells more efficient. One direction is to enhance the open-circuit voltage Voc by optimizing the emission of photons in the cell, where emission is a necessary loss process due to the reciprocity between absorption and emission of light. Here, we performed a Shockley-Queisser detailed balance analysis to predict the benefit of managin

Self-adaptation of software using automatically generated control-theoretical solutions

Control theory has contributed a set of foundational techniques to handle "change" at runtime in software applications. These techniques however have fundamental limitations as well: (i) they require the development and understanding of mathematical models; (ii) synthesizing solutions is often done on a per-problem basis, discouraging flexibility and generality. Software engineering, as a discipli

Ny dynastisk historia

Är det möjligt att diskutera ett nytt forskningsfält som heter ”ny dynastisk historia”? Fanns det då något som vi brukade benämna ”gammal dynastisk historia”? Detta bidrag hävdar att en ny dynastiska historia faktiskt finns – ett fält som har vuxit ut ur många andra fält, såsom statsbildningshistoria, hovstudier, adelsstudier, kvinnohistoria, familjehistoria med mera. Nya insikter om alla dessa fä

The Emergence of Hypervirulent M1T1 Clone of Group A Streptococcus via Genetic Recombination and Host Selection

Streptococcus pyogenes (Group A Streptococcus, GAS) is a strictly human bacterial pathogen. Since the mid-1980s, GAS M1T1 clone has been the most prevalent and globally disseminated serotype and is the culprit causing invasive and severe streptococcal infections, urging a better understanding of the emergence of hypervirulent M1T1 clone from an evolutionary perspective. This review highlights the

Education, Home Exercise, and Supervised Exercise for People With Hip and Knee Osteoarthritis As Part of a Nationwide Implementation Program : Data From the Better Management of Patients With Osteoarthritis Registry

Objective: To compare the effectiveness of education (ED) plus home exercise (HE) and ED plus supervised exercise (SE) according to information provided by the Better Management of Patients With Osteoarthritis (BOA) Registry, a nationally implemented rehabilitation program for patients with hip and knee osteoarthritis (OA). In addition, we investigated whether or not the effect of the treatments d

Confident millennials : Differences in consumer confidence across five generations

This paper investigates if individuals experiencing different socio-economic environments during their formative years have different expectations about future economic conditions. We use Swedish survey data to analyse differences in expectations across five generations of consumers by testing if they have different levels of confidence. The paper focuses on all the different generations of the 19

Identity, Image and Brand

This chapter highlights how organizational images and efforts to manage those images through branding influence the identities of individuals within organizations. The authors discuss the ways in which individuals’ identity projects are regulated, challenged, or supported by images and brands. They argue that identity is a particularly important concept for understanding organizing in today’s ‘bra

From carbohydrates to fat : Trends in food intake among Swedish nutrition students from 2002 to 2017

Earlier studies have implied a change in dietary habits of the Swedish population towards a low carbohydrate, high fat diet. Questions have been raised about the development in recent years and potential health effects. We have investigated the dietary intake of Swedish female students enrolled in a university nutrition course between 2002 and 2017. The students carried out self-reporting of all f

A meta-analysis of the efficacy of HAART on HIV transmission and its impact on sexual risk behaviours among men who have sex with men

Evidence showed preventive impacts of the highly active antiretroviral therapy (HAART) on the Human Immunodeficiency Virus (HIV) transmission amomg heterosexual population, however, that is of deficit among men who have sex with men (MSM). The aim was to systematically examine the efficacy of HAART on HIV transmission and the association between the HAART initiation and unprotected anal intercours

Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer’s disease

Physical exercise has been suggested to reduce the risk of developing Alzheimer’s disease (AD) as well as ameliorate the progression of the disease. However, we recently published results from two large epidemiological studies showing no such beneficial effects on the development of AD. In addition, long-term, voluntary running in the 5xFAD mouse model of AD did not affect levels of soluble amyloi

Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles

When in contact with biological fluids, nanoparticles dynamically absorb biomolecules like proteins and lipids onto their surface, forming a “corona”. This biocorona is a dynamic and complex structure that determines how host cells respond to nanoparticles. Despite the common use of mouse models in pre-clinical and toxicological experiments, the impact of corona formed in mouse serum on the biophy

Incompleteness and disgust predict treatment outcome in pediatric obsessive compulsive disorder

Increasing evidence suggests that pediatric obsessive-compulsive disorder (OCD) is underpinned not only by fear but by feelings of incompleteness and disgust, but it is currently unclear whether emotion-involvement in OCD symptoms is associated with treatment response in youth with OCD. The present study investigates whether treatment outcome for youth with OCD was predicted by the degree to which

Plant based production of myoglobin - a novel source of the muscle heme-protein

Myoglobin is a heme-protein in the muscle of vertebrates with important functions in the oxygenation of tissues and as a regulator in nitric oxide signaling. Myoglobin from many species is also an important nutritional source of bioavailable iron. In this study, we have successfully produced human myoglobin in the leaves of Nicotiana benthamiana by transient expression using a viral vector deliver

Linking Plant Functional Ecology to Island Biogeography

The study of insular systems has a long history in ecology and biogeography. Island plants often differ remarkably from their noninsular counterparts, constituting excellent models for exploring eco-evolutionary processes. Trait-based approaches can help to answer important questions in island biogeography, yet plant trait patterns on islands remain understudied. We discuss three key hypotheses li

Quantitative and qualitative consequences of reduced pollen loads in a mixed-mating plant

Greater pollination intensity can enhance maternal plant fitness by increasing seed set and seed quality as a result of more intense pollen competition or enhanced genetic sampling. We tested experimentally these effects by varying the pollen load from a single pollen donor on stigmas of female flowers of Dalechampia scandens (Euphorbiaceae) and measuring the effects on seed number and seed mass.

Using hierarchical joint models to study reproductive interactions in plant communities

Pollinator-mediated reproductive interactions among co-flowering plant species are prime examples of how species interactions may affect fitness and community assembly. Despite considerable interest in these issues, statistical methods for assessing signal of reproductive interactions in observational data on co-flowering species are currently lacking. We propose a flexible method for quantifying

Lichens facilitate seedling recruitment in alpine heath

Questions: How do mat thickness, physical structure and allelopathic properties of terricolous mat-forming lichens affect recruitment of vascular plants in dwarf-shrub and lichen heath vegetation?. Location: The mountains of Dovrefjell, central Norway. Methods: In autumn, seeds of ten vascular plant species were collected and sown in a common garden experiment with mats of six lichen species and b