Hematopoietic stem cells (HSCs) undergo a functional switch in neonatal mice hallmarked by a decrease in self-renewing divisions and entry into quiescence. Here, we investigated whether the developmental attenuation of B-1a cell output is a consequence of a shift in stem cell state during ontogeny. Using cellular barcoding for in vivo single-cell fate analyses, we found that fetal liver definitive

In this article we have analysed the ways a discourse on individualisation is taking shape within adult education in Sweden, how it operates, and what effects it has in terms of shaping student subjectivity. Drawing on a post-structural theorisation we analyse interviews with teachers and students in municipal adult education and folk high schools (FHS). The analysis illustrates how both instituti

Ligand exchange at square-planar [Pd(MeCN)4]2+ and [Pd(EtCN)4]2+ has been studied by 1H NMR line broadening and at [Pt(MeCN)4]2+ and [Pt(EtCN)4]2+ by isotopic labelling using 1H NMR spectroscopy in deuteriated nitromethane. Exchange takes place via two-term rate laws Rex/4 = (k1 + k2[RCN])cM with well defined k1 paths. Rate constants per co-ordination site k1298/s–1, k2298/kg mol–1 s–1 are 6.9 ± 1Ligand exchange at square-planar [Pd(MeCN)4]2+ and [Pd(EtCN)4]2+ has been studied by 1H NMR line broadening and at [Pt(MeCN)4]2+ and [Pt(EtCN)4]2+ by isotopic labelling using 1H NMR spectroscopy in deuteriated nitromethane. Exchange takes place via two-term rate laws Rex/4 = (k1 + k2[RCN])cM with well defined k1 paths. Rate constants per co-ordination site k1298/s–1, k2298/kg mol–1 s–1 are 6.9 ± 1

In 2013–2014, the IKEA cuddle toy Lufsig was connoted as a symbol of the Chief Executive (CE) of Hong Kong, prompting stakeholders to make negative associations with the corporation. Our study examines how IKEA mediated communication on traditional media and social media to turn this crisis into an opportunity. This study informs corporate communicators and researchers about the integrated utiliza

The aim of this paper is to contribute to an actantial approach to building type studies through a study of the visitor centre and its role in contemporary spatial production. The article takes its empirical departure in the (from a Swedish perspective) intense urbanization of the Scania region, in the southern part of Sweden. Looking at building types in terms of actants implies that different se

This study examines the relationship between trade and the quality of economic institutions under different political institutions. It uses panel data of 138 countries from 1984 to 2010 and employs instrumental variables and identification through heteroscedasticity to mitigate the problem of endogeneity. The findings suggest that the effect of trade on economic institutions reduces significantly

There is an increasing demand for real world evidence. The shift towards relative effectiveness assessment increasingly based on real world data is a natural consequence of the shift towards new adaptive pathways for development and introduction of new medicines in cancer care. The increasing number of alternative treatment options will further increase the need for outcomes data to help optimize

Scientific and clinical communities produce ever increasing amounts of data and details about health and disease. Our ability to understand and utilize this information is limited because of imprecise language and lack of well-defined concepts. This problem involves also the principal concepts of health, disease, and pathogenicity. Here, a systematic model is presented for pathogenicity, as well a

Abstract The Ni-YSZ cerment as a promising anode for solid oxide fuel cells and its performance strongly depends on its miscrocture. This work focused on fabrication of Ni-8YSZ nanofibers via an electrospinning technique using yttria and zirconia nanoparticles as precussors. The effects of viscosity on the quality of fibers were assessed by adjusting the polymer and solid contents in slurry. The f

Boreal/arctic wetlands are dominated by diverse plant species, which vary in their contribution to CH4 production, oxidation and transport processes. Earlier studies have often lumped the processes all together, which may induce large uncertainties into the results. We present a novel model, which includes three vegetation classes and can be used to simulate CH4 emissions from boreal and arctic tr

In osteopetrosis, osteoclast dysfunction can lead to deafness, blindness, bone marrow failure, and death. Hematopoietic cell transplantation (HCT) is currently the only curative treatment, but outcome remains disappointing. Although a rapid progression toward HCT is detrimental to prevent further progress of disease manifestations, 70% of cases lack an HLA-matched sibling and require alternative s