Challenges in the treatment of malignant glioma with oncolytic adenovirus
Malignant glioma is a tumor that spreads rapidly throughout brain and is almost impossible to remove completely by surgery. It is resistant to chemo- and radiotherapy and the prognosis is very poor. As a result, there is a desperate need for development of novel therapies against this devastating disease. Because of the heterogeneity in this cancer success has been limited, but a recent concept in