OBJECTIVE—Insulin detemir is a soluble long-acting basal insulin analog designed to overcome the limitations of conventional basal insulin formulations. Accordingly, insulin detemir has been compared with NPH insulin with respect to glycemic control (HbA1c, prebreakfast glucose levels and variability, and hypoglycemia) and timing of administration. RESEARCH DESIGN AND METHODS—People with type 1 d

The effect of multivariate adjustment including folate on the strong protective effect of fiber in foods on colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition was investigated in 1,721 cases identified in the latest follow-up. The inclusion of an additional 656 cases confirmed our previously published results, with a strong and significant reduction in color

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The importance of risk characteristics of human capital for the design of tax and education policy is explored. Wages are uncertain and education, while increasing the expected wage, may increase or decrease wage variance. The government has strong reasons to encourage human capital formation in the latter case, partly due to the insurance effect of human capital, and partly due to the way the ind

The vapour-liquid partition of various VOC (Volatile Organic Compounds) in a number of industrial black liquors was investigated. The information can be used to determine the distribution of VOC in different condensate and gas streams in a kraft mill. Batchwise evaporation of weak black liquors was performed on a lab scale. The evaporation was carried out at atmospheric pressure up to over 90% dry

Background The study was designed to evaluate the analgesic effect and possible adverse effects of acupuncture for pelvic and low-back pain during the last trimester of pregnancy. Methods Following individual informed consent, 72 pregnant women reporting pelvic or low-back pain were randomized during pregnancy weeks 24-37 to an acupuncture group (n = 37) or to a control group (n = 35) at three mat

Förmaksflimmer är en vanlig och behandlingskrävande hjärtrytmrubbning. Det kroniska förmaksflimret finner man i befolkningen från 50-årsåldern i alltmer ökande omfattning. Antalet individer i Norge med denna rytmrubbning beräknas vara drygt 40000 och ökar med ytterligare cirka 5000 till år 2010. Mekanismerna bakom initiering och underhåll av förmaksflimmer kartläggs allt bättre. Den paroxysmala foAtrial fibrillation is a common and therapy-requiring cardiac arrhythmia. The chronic form becomes identified in population studies from the age of 50 and increases with age. The number of Norwegian individuals with this arrhythmia is estimated to be slightly in excess of 40,000 and it will increase approximately by another 5,000 until the year 2010. Mechanisms responsible for initiation and maint

The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression

The development and transplantation of autologous cells derived from nuclear transfer embryonic stem cell (NT-ESC) lines to treat patients suffering from disease has been termed therapeutic cloning. Human NT is still a developing field, with further research required to improve somatic cell NT and human embryonic stem cell differentiation to deliver safe and effective cell replacement therapies. F

We propose a Viterbi-type decoder for tailbiting trellis codes that works by traversing the tailbiting circle somewhat more than once. The traversal is the least possible for any bounded distance Viterbi decoder. Procedures are given that compute this minimum. Unlike previous decoders of the type, the new scheme does not suffer limit cycles or from pseudocodewords. The bit-error rate is compared t

We present the first study of dipole and quadrupole moments of liquid water calculated using coupled cluster/molecular mechanics (COMM) methods. CUMM methods are used to calculate the total dipole moment of the water dimer and the results are compared to the corresponding ab initio quantum mechanical calculations. For liquid water we find that the introduction of polarization effects are very impo

A new method for absorbed-dose assessment in radionuclide therapy is presented in this paper. The method is based on activity quantification by the conjugate-view methodology, applied to serial whole-body, anterior-posterior, scintillation-camera scans. The quantification method is an extension of previous studies, and includes separate corrections for attenuation, scatter, and overlapping organs.

The Fra a I allergen in strawberry (Fragaria ananassa) is homologous to the major birch pollen allergen Bet v 1, which has numerous isoforms differing in terms of amino acid sequence and immunological impact. To map the extent of sequence differences in the Fra a I allergen, PCR cloning and sequencing was applied. Several genomic sequences of Fra a 1, with a length of either 584, 591 or 594 nucleo

Background: TNF alpha is a cytokine that may contribute to the pathophysiology of airway inflammation. Inhalation of TNF alpha produces granulocyte recruitment and airway hyperresponsiveness in man. Anti-TNF alpha treatment may inhibit allergen-induced plasma exudation in guinea-pig airways. Increased nasal mucosal output of TNF alpha has been demonstrated in allergic rhinitis, but the effect of T

The effect of hyperthermia and/or nicotinamide (200 mg/kg of body weight) on the tumour growth delay induced by radiation was evaluated in a C3H mouse mammary adenocarcinoma. The study showed a radiosensitizing effect of hyperthermia and of nicotinamide but the combination of all three modalitites showed no increased tumor growth delay compared to hyperthermia and radiation alone. The tumour growt

Mean lifetimes of high-spin states of Kr-74 have been determined using the Doppler-shift attenuation method. The high-spin states were studied using the Ca-40(Ca-40, alpha 2p) reaction at a beam energy of 160 MeV with the GASP gamma-ray spectrometer. The ground-state band and negative parity side band show the presence of three different configurations in terms of transitional quadrupole deformati