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Multiple induced abortions–implications for counselling and contraceptive services from a multi-centre cross-sectional study in Sweden

Objectives: To investigate factors associated with multiple induced abortions. Materials and methods: A multi-centre cross-sectional survey among abortion-seeking women (n = 623;14-47y) in Sweden, 2021. ‘Multiple abortions’ was defined as having had ≥2 induced abortions. This group was compared to women with a previous experience of 0-1 induced abortion. Regression analysis was conducted to determ

All-Optical Switching Based on Sub-Bandgap Photoactivation of Charge Trapping in Metal Halide Perovskites

Controllable optical properties are crucial for the application of light-emitting materials in optical devices. In this work, controllable photoluminescence in metal halide perovskite crystals is realized via photoactivation of their defects. It is found that under continuous excitation, the photoluminescence intensity of a CH3NH3PbBr3 crystal can be fully controlled by sub-bandgap energy photon i

Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics Cohort Using Multistate Modeling

Objective: To estimate direct and indirect costs associated with neuropsychiatric (NP) events in the Systemic Lupus International Collaborating Clinics inception cohort. Methods: NP events were documented annually using American College of Rheumatology definitions for NP events and attributed to systemic lupus erythematosus (SLE) or non-SLE causes. Patients were stratified into 1 of 3 NP states (n

Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism : a Mendelian randomisation study

Aims/hypothesis: The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD), mild diabetes (MD) and mild diabetes with high HDL-cholesterol (MDH). This was t

Histidine oxidation in lytic polysaccharide monooxygenase

The lytic polysaccharide monooxygenases (LPMOs) comprise a super-family of copper enzymes that boost the depolymerisation of polysaccharides by oxidatively disrupting the glycosidic bonds connecting the sugar units. Industrial use of LPMOs for cellulose depolymerisation has already begun but is still far from reaching its full potential. One issue is that the LPMOs self-oxidise and thereby deactiv

Policy measures to reduce stereotypical representations of older people in long-term care

Older people are stereotypically portrayed in the media at two extremes of a spectrum, either the healthy and happy retiree, or the fragile and sick older person in need of care. Older people living in residential long-term care are particularly portrayed in a homogenous way. Individuals exposed to stereotypical portrayals could develop a distorted view of the realities of older people and later l

Tracing Sustainability in the Long Run : Genuine Savings Estimates 1850 - 2018

We introduce a new database of historical Genuine Savings (GS), an indicator of sustainable development promoted by the World Bank and widely used in contemporary economic research. GS derives from the theoretical work on wealth accounting, and addresses shortcomings in conventional metrics of economic development by incorporating broader measures of saving and investment, including human capital

What is new in type 1 diabetes? [Video file]

Topics Covered - Genetic etiology- Autoantibodies as biomarkers- Autoantibodies predict clinical onset of diabetes- TEDDY study- DIPP study- Etiology and pathogenesis of type 1 diabetes- IAA-first or GADA-first

The humans of ancient Hermione : the necropolis in the light of bioarchaeology

Bioarchaeology has the potential to substantially inform about ancient lifeways through osteological analyses of the remains of the once living individuals. This article provides insights of the demography and health of the people of ancient Hermione (Geometric-Roman period). A minimum number of 85 individuals from the Hermione necropolis was osteologically analyzed. Although the analysis was limi

Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants

Background: Vaccine development for Group B Streptococcus (GBS), a common cause of invasive disease in early-infancy and adverse pregnancy outcomes, include exploring widely-expressed GBS surface proteins as vaccine epitopes. We investigated the association between natural infant serum IgG against the RibN and Alp1N domains and risk of invasive GBS disease caused by isolates expressing these prote

Isospin-breaking corrections to light-meson leptonic decays from lattice simulations at physical quark masses

The decreasing uncertainties in theoretical predictions and experimental measurements of several hadronic observables related to weak processes, which in many cases are now smaller than O(1%), require theoretical calculations to include subleading corrections that were neglected so far. Precise determinations of leptonic and semi-leptonic decay rates, including QED and strong isospin-breaking effe