Angiogenesis is a hallmark of expanding tissue e.g. during embryogenesis and wound healing in physiology as well as in diseases such as cancer and atherosclerosis. Key steps of the angiogenic process involve growth factor-mediated stimulation of endothelial cell sprouting and tube formation. Heparan sulphate proteoglycans (HSPGs) have been implicated as important co-receptors of several pro-angiog

Human epidermal growth factor receptor type 2 (HER2)-positive breast carcinoma is highly aggressive and mostly metastatic in nature though curable/manageable in part by molecular targeted therapy. Recent evidence suggests a subtype of cells within HER2-positive breast tumors that concomitantly expresses the urokinase plasminogen activator receptor (uPAR) with inherent stem cell/mesenchymal-like pr

Objective: There are several neuropathological scales for staging of Alzheimer pathology. The system proposed by Braak and Braak is based on the topographic distribution of neurofibrillary tangles and neuropil threads, while that of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is based on the quantity of neocortical neuritic plaques. A combination of the Braak and CERAD s

AIMS: To investigate the association between socioeconomic status, unemployment and self-rated psychological health, taking economic stress and horizontal trust into account. Design/setting/participants/measurements: The 2008 public health survey in Skåne is a cross-sectional postal questionnaire study with a 55% participation rate. A random sample was invited and 28,198 persons aged 18-80 partici

Kulturartikel om filmstjärnan James Dean, hans eftermäle och mytbildningen kring honom

Det är nu femton år sedan Gun Andersson drabbades av en hjärnblödning. Hon använder sig dagligen av sin digitala kamera och har under åren efter hjärnblödningen med jämna mellanrum i form av rapporter dokumenterat sina framsteg. Detta är den senaste.

Departing from fundamental concepts, this paper briefly recaps the case-law development with respect to refusal to deal on both sides of the Atlantic; revisits the EU Guidelines and recent U.S. development, and finally considers refusal to license. All with the purpose to understand whether the 2009 Guidelines actually restate the law as it stands today.

Begreppen "lag" och "ordning" tycks betinga varandra. Lagen kan sägas vara garanten för ordningens upprätthållande, ett slags juridisk kodifiering av samhällets ordningsskapande föresatser. Men omvänt förutsätter lagen en ordning. Det måste finnas legitima institutioner med auktoritet att stifta och upprätthålla lagarna. Regler kan inte tillämpas på kaos, och under de senaste åren har man i debatt

Story-telling is increasingly accepted as a management strategy aiming to build commitment to, and acceptance for, ideas, brands and organizations. But what happens when story-telling meets transparency demands in public sector reform? This topic is explored in this paper. It builds on a case study of a major public sector reform, including the merger of two hospitals in the south of Sweden. The s