Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit

AIMS: To present descriptive data, study psychometric abilities, and investigate the characteristics of non-respondents to SF-12. METHOD: The study had a randomized sample (n=4278; age: 75-105) stratified in four age groups. Factor analyses were performed to investigate the factor structure of the instrument, and convergent and discriminant validity was assessed by correlation between summary scor

A prospective study of incident hepatitis C in 515 gastroenterology patients was conducted by follow-up sampling at 3-6 months after admission to the gastroenterology unit to test for antibodies to hepatitis C virus and for hepatitis C virus RNA. Universal precautions were implemented, and the use of multidose vials had been banned in this unit. Despite 5,964 exposure-days for several risk factors

Vernalization, the acceleration of flowering by a long period of cold temperature, ensures that many plants overwinter vegetatively and flower in spring. In Arabidopsis, allelic variation at the FRIGIDA (FRI) locus is a major determinant of natural variation in flowering time. Dominant alleles of FRI confer late flowering, which is reversed to earliness by vernalization. We cloned FRI and analyzed

The purpose was to investigate whether a new biphasic and injectable ceramic bone substitute Cerament™ that rapidly remodels to bone, may contribute to the retention of titanium implant screws during the healing period, and to analyze the pattern of bone formation around titanium implants.Titanium screws were implanted in rat tibiae and embedded with or without Cerament™ on the cortical surface. T

Popular Abstract in Swedish Utveckling och tillämpning av laserfragmentationsteknik för visualisering av väteperoxider Laserinducerad fluorescens är en etablerad optisk mätmetod för kemiskt specifik detektion och avbildning med tillämpning inom fysik, kemi och biologi. Tekniken bygger på att molekyler ska absorbera laserljus och sedan spontant sända ut ljus som kan detekteras. Det finns dock mångaThe work presented in this thesis is mainly motivated by the need for an optical diagnostic technique which can be used to visualize hydrogen peroxide (H2O2) in its gas phase. Due to the lack of bound electronic states, H2O2 cannot be detected using laser-induced fluorescence based on electronic excitation. Absorption in the ultraviolet leads to photodissociation. Thus a technique called photofrag

Overwash, the flow of water and sediment over the crest of a beach, contributes to flooding and the deposition of sand landward of the beach crest. Washover, the sand deposited by overwash, contributes to the sediment budget and migration of barrier islands. The ability to predict the occurrence, location, and thickness of overwash deposits is important for coastal residents, coastal town planners