PREPARATION OF CLASS I AND III RIBONUCLEOTIDE REDUCTASE (RNR) AND ROLE OF THE ATP-CONE DOMAIN
Ribonucleotide reductases (RNR) are key enzymes for transformation of RNA building blocks (NTPs) to DNA building blocks (dNTPs), an essential step in biological systems. RNRs are known to be the first enzymes identified with free radical chemistry and play an important role in having a tight control over dNTP levels, as these DNA building blocks are needed for vital cellular processes such as cell
