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Patients Referred for Bleeding Symptoms of Unknown Cause : Does Evaluation of Thrombin Generation Contribute to Diagnosis?
INTRODUCTION: Patients with mild to moderate bleeding symptoms referred for coagulation investigation sometimes never receive a definitive diagnosis. Bleed assessment tools have been developed and validated to assess the severity of symptoms. Global coagulation assays, e.g., the thrombin generation test (thrombogram) have a potential to identify hemostatic defects that are not detected in specific
ORGAN DOSES AND EFFECTIVE DOSE FOR FIVE PET RADIOPHARMACEUTICALS
Diagnostic investigations with positron-emitting radiopharmaceuticals are dominated by (18)F-fluorodeoxyglucose ((18)F-FDG), but other radiopharmaceuticals are also commercially available or under development. Five of them, which are all clinically important, are (18)F-fluoride, (18)F-fluoroethyltyrosine ((18)F-FET), (18)F-deoxyfluorothymidine ((18)F-FLT), (18)F-fluorocholine ((18)F-choline) and (
Matching authority and VGI road networks using an extended node-based matching algorithm
The amount of volunteered geographic information (VGI) has increased over the past decade, and several studies have been conducted to evaluate the quality of VGI data. In this study, we evaluate the completeness of the road network in the VGI data set OpenStreetMap (OSM). The evaluation is based on an accurate and efficient network-matching algorithm. The study begins with a comparison of the two
A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women
BACKGROUND/AIM: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II.PATIENTS AND METHODS: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) wer
Measuring and Evaluating Bitumen Coverage of Stones using two Different Digital Image Analysis Methods
The most used pavement for paved roads in the world is asphalt. It is therefore important that the asphalt is as durable as possible to avoid expensive repairs of the roads. One important factor of the durability of the road is the adherence between the stones and the bitumen that holds the stones together. The affinity is tested by the so called rolling bottle test, where one put stones covered i
Treatment with oral anticoagulant drugs restrained from patients with atrial fibrillation : An assessment in a geographically well-defined catchment area
BACKGROUND: Atrial fibrillation (AF) affects about 3.2% of the adult population in the western world and incurs an annual stroke risk of 4.5%. The use of oral anticoagulant (OAC) drugs significantly reduces this risk. OAC drugs seem to be under-utilized, but little is known about why their use is restrained in routine clinical management. The aim of this study was to assess this issue and, from th
Leukemic stem cell quantification in newly diagnosed chronic myeloid leukemia patients predicts response to nilotinib therapy
PURPOSE: Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We identified Philadelphia chromosome (Ph) positive CD34+CD38- bone marrow cells (here denoted LSCs) and addressed their response-predictive value in CML patients (n=48) subjected to nilotinib in the ENEST1st trial (NCT01061177).EXPERIMENTAL DESIGN: Two flow cytometr
The Respiratory Pathogen Moraxella catarrhalis Targets Collagen for Maximal Adherence to Host Tissues
Moraxella catarrhalisis a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step inM. catarrhaliscolonization is adherence to the mucosa, epithelial cells, and extracellular matrix (ECM). The objective of this study was to evaluate the role ofM. catarrhalisint
Cost effectiveness of pomalidomide in patients with relapsed and refractory multiple myeloma in Sweden
Background: Multiple myeloma (MM) patients who have progressed following treatment with both bortezomib and lenalidomide have a poor prognosis. In this late stage, other effective alternatives are limited, and patients in Sweden are often left with best supportive care. Pomalidomide is a new anti-angiogenic and immunomodulatory drug for the treatment of MM. Our objective was to evaluate the cost e
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished Y949 signalling in the mouse mutant Vegfr2(Y949F/Y949F) leads to VEGFA-resistant endothelial adhere
Nurses’ Patient Education Questionnaire – development and validation process
Conditions for nurses’ daily patient education work are unclear and require clarification. The aim was to develop and validate the Nurses’ Patient Education Questionnaire, a questionnaire that assesses nurses’ perceptions of appropriate conditions for patient education work: what nurses say they actually do and what they think about what they do. The questionnaire was developed from a literature r
‘Mislabelled’ make-up remover gave facial eczema in female patients
Incorrectly labelled cosmetic wet wipes can cause severe eczema, leading to major concerns amongst the public. Read below what was revealed by chemical analysis in a laboratory in Malmö, Sweden.
On shrinking targets for piecewise expanding interval maps
For a map (Formula presented.) with an invariant measure (Formula presented.), we study, for a (Formula presented.)-typical (Formula presented.), the set of points (Formula presented.) such that the inequality (Formula presented.) is satisfied for infinitely many (Formula presented.). We give a formula for the Hausdorff dimension of this set, under the assumption that (Formula presented.) is piece
Injection of electrons by colliding laser pulses in a laser wakefield accelerator
To improve the stability and reproducibility of laser wakefield accelerators and to allow for future applications, controlling the injection of electrons is of great importance. This allows us to control the amount of charge in the beams of accelerated electrons and final energy of the electrons. Results are presented from a recent experiment on controlled injection using the scheme of colliding p
Numerical investigation of vibration reduction in multi-storey lightweight buildings
In order to reduce the vibration transmission in multi-storey wood buildings, it is common to insert viscoelastic elastomer materials between parts of the buildings. The studies presented here investigate to which extent different design choices for the elastomer layers affect the isolation of low-frequency vibrations (0-100 Hz). A finite element model of two storeys of a multi-storey wood buildin
Genome wide association study identifies two loci associated with cadmium in erythrocytes among never-smokers
BACKGROUND: Cadmium is a non-essential toxic metal with multiple adverse health effects. Exposure in the general population occurs by smoking and diet. Cadmium in erythrocytes is a valid biomarker of exposure and body burden of cadmium.OBJECTIVES: We aimed to identify genetic variants related to concentrations of cadmium in erythrocytes.METHODS: Erythrocyte cadmium was analyzed in 4432 individuals
Wind turbine tower resonance
Wind turbine towers are large structures designed to withstand the unique loading conditions imposed on them by the turbine's nacelle and dynamic forces from the rotating blades. Observations and noise measurements of a particular wind turbine showed high noise levels at approximately 48 Hz, which could not be explained from the usual known potential noise sources. Correlated far field noise measu
Analysis of x-ray emission and electron dynamics in a capillary-guided laser wakefield accelerator
The dynamics of electron acceleration driven by laser wakefield inside a 30.5 mm long dielectric capillary tube is analyzed using radiation emitted in the x-ray range. 3D particle-in-cell simulations, performed with parameters close to the experimental ones, show that in long plasmas, the accelerated electrons catch up and finally overrun the driving laser owing to a higher velocity of the electro
Vibration insulation of footbridges so as to reduce human discomfort
Low frequency vibrations in footbridges is a cause of annoyance for pedestrians crossing the bridge. Bagers bro, a footbridge built in Malmö (Sweden) had several constraints in the physical design that caused the first eigenmode of the bridge to be at 1.8Hz which is a severe problem for pedestrians. Therefore the bridge was fitted with tuned mass dampers to mitigate the vibration problem. To evalu