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Tissue Factor Pathway Inhibitor (TFPI) is a naturally occurring inhibitor of the TF-FVIIa induced coagulation in the presence of FXa. Recombinant two domain TFPI, where Asn 117 on the FXa-inhibitory domain was exchanged to a Gln yielding non-glycosylated TFPI (117QTFPI1-161), was evaluated regarding pharmacokinetics and delayed antithrombotic potential in the rabbit. Pharmacokinetic study 117QTFPI

We have earlier shown that both full-length and truncated glycosylated tissue factor pathway inhibitor (TFPI) lacking the third Kunitz domain and the c-terminal region has an antithrombotic effect comparable to low-molecular-weight heparin (LMWH) in an experimental venous thrombosis model. The aim of this study was to investigate whether a recombinant truncated non-glycosylated TFPI (117QTFPI1-161

Populärvetenskaplig sammanfattning1,7 miljoner nya fall av bröstcancer diagnosticeras årligen i världen. Bröstcancer är kvinnans vanligaste tumörsjukdom och i västvärlden samt Sverige kommer var åttonde till var nionde kvinna att insjukna under sin livstid. Överlevnaden efter bröstcancer är bland de högsta i världen i Sverige, med femårsöverlevnad på cirka 90%. För de kvinnor som diagnosticeras i Most patients with breast cancer present with low-risk tumors, node-negative disease, and excellent prognosis. For these patients, routine axillary nodal staging by sentinel lymph node biopsy (SLNB) has no therapeutic benefit. For patients with limited sentinel lymph node metastasis, completion axillary nodal dissection is controversial. Furthermore, those with heavy-burden metastasis could benefi

Dual system models postulate two distinct neural mechanisms for the processing of inflected words: irregular forms (e.g. ‘went’) are assumed to be directly accessed as whole word representations, whereas regularly inflected items (e.g. ‘played’) might undergo rule-based decomposition (Pinker & Ullman, 2002). Irregular verb stems incorrectly carrying a regular inflectional suffix have been repo

Sustainability in Housing First-pilotsThe Housing First service in Helsingborg (Sweden) started as a pilot project in September 2010. The evaluation that we carried out during the services first years showed positive results, including a high housing stability rate. The results of the evaluation became important arguments when the city of Helsingborg decided to make the Housing first project to a The Housing First service in Helsingborg (Sweden) started as a pilot project in September 2010. The evaluation that we carried outduring the service first years showed positive results, including a high housing retention rate. The results of the evaluation becameimportant arguments when the city of Helsingborg decided to make the Housing first project a permanent part of their social housingprogra

Background: Clinical reasoning has been proposed to be a key attribute of health professionals. We hypothesized that clinical reasoning may be one explicit way to further the understanding of each other’s roles in interprofessional learning activities, for nurse students and physiotherapy students. Objectives: The first part of this paper was a literature review. In the second part of the paper, w

Background: Up-to-date epidemiological stroke studies are important for healthcare planning and evaluating prevention strategies. This population-based study investigates temporal trends in stroke incidence and case-fatality in southern Sweden. Methods: First-ever stroke cases in the local catchment area of Skåne University Hospital in Lund, Sweden, between March, 2015 and February, 2016, were inc

A new method to improve the accuracy and efficiency of CM decomposition for perfectly conducting bodies is presented. The method uses the expansion of the Green dyadic in spherical vector waves. This expansion is utilized in the MoM solution of the EFIE to factorize the real part of the impedance matrix. The factorization is then employed in the computation of CM, which improves the accuracy as we

The overall purpose of this thesis is to improve our understanding of how disaster risk management (DRM) systems function. Specifically, it aims to increase our knowledge about effective communication in a multi-stakeholder, multi-level DRM system, with a particular focus on the exchange of risk-related information for risk assessment. The Swedish DRM system is taken as a study case to examine how

Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, o

This paper examines whether or not specific forms of adaptation governance that involve city administrations and citizens can help (or hinder) creating a foundation for more sustainable climate adaptation and transformation. Based on the analysis of recurring patterns of social adaptation dilemmas (caused by the interdependencies between adaptation providers and beneficiaries), associated actor co

Objective: To study the trends of transmitted drug resistance (TDR) in HIV-1 patients newly diagnosed in Sweden, 2010-2016. Design: Register-based study including all antiretroviral therapy-naive patients ≥18 years diagnosed with HIV-1 in Sweden 2010-2016. Methods: Patient data and viral pol sequences were extracted from the national InfCareHIV database. TDR was defined as the presence of surveill

Semiconductor nanowire lasers can produce guided coherent light emission with miniaturized geometry, bringing about new possibilities for a variety of applications including nanophotonic circuits, optical sensing, and on-chip and chip-to-chip optical communications. Here, we report on the realization of single-mode and room-temperature lasing from 890 to 990 nm, utilizing a novel design of single

This article investigates digital predistortion (DPD) linearization of hybrid beamforming large-scale antenna transmitters. We propose a novel DPD processing and learning technique for an antenna sub-array, which utilizes a combined signal of the individual power amplifier (PA) outputs in conjunction with a decorrelation-based learning rule. In effect, the proposed approach results in minimizing t

Purpose: The purpose of this paper is to investigate the dynamic process of brand meaning creation by multiple stakeholders during corporate rebranding in the digital environment. Design/methodology/approach: By applying a symbolic interactionist perspective, the case study analyses a failed corporate rebranding of Gap. A variety of narratives by managers, consumers, designers, and marketing profe