The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole g

Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated wit

I november 1906 utkom första numret av Folkets väl. Denna ”tidning för tro och fosterland” presenterade sig som en ny konservativ röst i ett Sverige som höll på att fördärvas av socialism, gudsförnekelse och antimilitarism. Men mellan raderna dolde sig en smädeskrift riktad mot det borgerliga samhället och dess makthavare.Bakom den skenheliga tidningen stod typografen, författaren och anarkisten E

The stigmatizing attitude towards people living with HIV/AIDS (PLWHA) can be a major barrier to effective patient care. As future physicians, medical students represent a core group that should be targeted with focused knowledge and adequate training to provide patient care without prejudice. The aim of the current study was to examine HIV/AIDS knowledge, and the stigmatizing attitude towards PLWH

Tropical forests contribute a major sink for anthropogenic carbon emissions essential to slowing down the buildup of atmospheric CO2 and buffering climate change impacts. However, the response of tropical forests to more frequent weather extremes and long-recovery disturbances like fires remains uncertain. Analyses of field data and ecological theory raise concerns about the possibility of the Ama

Ulnar nerve compression at the elbow (UNE) frequently affects people of working age. Surgically treated patients may not immediately return to work (RTW) postoperatively. In 2008, the Swedish Social Insurance Agency reformed the national insurance policy. We aimed to examine RTW postoperatively for UNE, variations among surgical methods, and potential risk factors for prolonged RTW (sick leave > 6

The formulation of niosomes is influenced by a number of variables, and these variables may eventually affect the formulation's outcome. One of the elements that can influence the physico-chemical properties of niosomes is the method used in preparation of the formulation. In this study, we established if various methods of preparation have any impact on the prepared vesicles when loaded with 5-fl

Ghost Installation: Sparvkvarteren was part of the same evening that Deuterium: Virkesvägen was composed for. It was made with a single, combined recording of sparrows from Solna, Tensta and Hammarby, two clips of synthesizer material, and two recordings of the construction machinery closing in on Virkesvägen 3, recorded the same week we made our event in the Coyote Collective’s exhibition, Pionee

Casey Moir arranged this event in her neighborhood of Bredäng. It was a sound walk, punctuated with improvised music performances. First we encountered Moir, who worked with voice and objects in a pedestrian tunnel, blending unexpectedly and marvelously with a family fair going on nearby. Then we went up a granite hill to listen to Finn Loxbo play extended acoustic guitar, contemplative and still

This article is about my electroacoustic, multichannel work, Norra bantorget, composed in 2013, and premiered that year at Audiorama. The work addresses the psychogeography of Stockholm, and specifically the square at the site of the old central station.

Denna studie undersöker hur boende i området Södra Sofielund/Seved beträder bostadsområdet från sina hem. Materialet utgörs i huvudsak av fyra walkalong-intervjuer samt intervjupersonernas egna inrigningar av området. Genom en queer fenomenologisk analys synliggörs förutsättningar hos intervjupersonerna för hur området uppfattas och förhållningssätt som uppstår. Studien har även undersökts hur ter

Here we present a benchmarking dataset of fluorescence microscopy images with Hoechst 33342-stained nuclei together with annotations of nuclei, nuclear fragments and micronuclei. Images were randomly selected from an RNA interference screen with a modified U2OS osteosarcoma cell line, acquired on a Thermo Fischer CX7 high-content imaging system at 20x magnification. Labelling was performed by a si

Shopping for second-hand clothes is a phenomenon that has been on the rise, especially for the last twenty years. Second-hand clothes (SHC) consumption is a consumer-generated shopping trend whose consumers are discursively creating new identity meaning(s) for themselves out of their consumption. It has changed the outlook to become a fashionable trend in the last 20 years and is positively influe

Willingness to pay (WTP) for booster doses of coronavirus disease 2019 (COVID-19) vaccines is an under studied research topic. Therefore, the current study aimed to investigate the WTP for the booster doses of COVID-19 vaccines and its predictors in Indonesia using an online survey distributed all over the provinces of this low-middle-income country. The WTP was evaluated using a basic dichotomous

The building industry has a major impact on the global carbon emissions, the use of natural resources and generation of waste. A drastic change is needed for this industry to be a part of a sustainable future. Within this research, a case study is performed to investigate how cultural values of a building can be preserved when energy efficiency measures are taken, with a low global warming potenti

Despite increased female educational attainment and labor market participation, labor markets around the world remain characterized by vertical and horizontal gender segregation. This chapter reviews recent findings from the experimental economics literature that shed light on some of the causes of gender differences in labor market outcomes. First, it reviews the recent literature using incentivi

Background: Most antidepressant treatment studies have included patients strictly based on the Diagnostic and Statistical Manual of Mental Disorders definition of Major Depressive Disorder (MDD). Given the heterogeneity of MDD, this approach may have obscured inter-patient differences and hampered the development of novel and targeted treatment strategies. An alternative strategy is ​​to use bioma

Wood is a remarkable material with great cultural, economic, and biogeochemical importance. However, our understanding of its formation is poor. Key properties that have not been explained include the anatomy of growth rings (with consistent transitions from low-density earlywood to high density latewood), strong temperature-dependence of latewood density (used for historical temperature reconstru

Why and how new migration routes emerge remain fundamental questions in ecology, particularly in the context of current global changes. In its early stages, when few individuals are involved, the evolution of new migration routes can be easily confused with vagrancy, i.e. the occurrence of individuals outside their regular breeding, non-breeding or migratory distribution ranges. Yet, vagrancy can