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This study investigates how variations in Arctic sea ice and sea surface conditions influence δ18O of present-day Arctic precipitation. This is done using the model isoCAM3, an isotope-equipped version of the National Center for Atmospheric Research Community Atmosphere Model version 3. Four sensitivity experiments and one control simulation are performed with prescribed sea surface temperature (S
Background: While walking difficulties are common in people with Parkinson's disease (PD), little is known about factors that independently contribute to their perceived walking difficulties. Objective: To identify factors that independently contribute to perceived walking difficulties in people with PD.Methods: This study involved 243 (62% men) participants; their mean (min-max) age and PD durati
The security behavior of small states has traditionally been explained by different takes of realism, liberalism, or constructivism – focusing on the behavior that aims toward safeguarding sovereignty or engaging in peace policies. The issue of why states with limited military capacities and little or no military alignments or engagements decide to participate in an international mission has recei
Lecture at American University of Rome
Purpose: The purpose of this concept study was to investigate the possibility of automatic mean arterial pressure (MAP) regulation in a porcine heart-beating brain death (BD) model. Hemodynamic stability of BD donors is necessary for maintaining acceptable quality of donated organs for transplantation. Manual stabilization is challenging, due to the lack of vasomotor function in BD donors. Closed-
In this thesis we extend several classical results about Calderón-Zygmund operators to spaces of vector-valued functions. We first obtain bounds for the norm of dyadic Haar shift operators using a Bellman function technique, and then apply the representation theorem to obtain corresponding results for general Calderón-Zygmund operators. We discuss several results for UMD space-valued Calderón-Zygm
Traditional frontier literature identifies a positive correlation between land availability and fertility. A common explanation is that the demand for children as labour is higher in newly established frontier regions compared to older and more densely populated farming regions. In this paper we contribute to the debate by analysing the relationship between household composition and land availabil
This chapters looks at the Swedish financial revolution in a long-term perspective. It begins with the establishment of the first formal financial organization, the Stockholm Banco in 1656, and follows the financial development until the end of the nineteenth century. The development of each part of the financial system is described in relation to the financial, economic, and political development
Background and aim: Due to an increasingly ageing population, the number of hip fracture patients, often with multiple chronic diseases and multiple pharmacotherapy, is set to rise. The high risk of adverse outcomes that hip fractures lead to in older individuals is well described, including high first-year mortality. This thesis aim to improve our knowledge of older hip fracture patients’ treatme
Precision medicine requires accurate multi-gene clinical diagnostics. We describe the implementation of an Illumina TruSight Tumor (TST) clinical NGS diagnostic framework and parallel validation of a NanoString RNA-based ALK, RET, and ROS1 gene fusion assay for combined analysis of treatment predictive alterations in non-small cell lung cancer (NSCLC) in a regional healthcare region of Sweden (Sca
We previously demonstrated that small cell lung carcinoma (SCLC) cells lack HIF-2α protein expression, whereas HIF-1α in these cells is expressed at both acute and prolonged hypoxia. Here we show that low HIF2A expression correlates with high expression of MYC genes. Knockdown of HIF1A expression had no or limited effect on cell survival and growth in vitro. Unexpectedly, hypoxic ATP levels were n
INTRODUCTION: Large cell carcinoma with or without neuroendocrine features (LCNEC and LC, respectively) constitutes a small proportion of non-small cell lung cancer (NSCLC). The WHO2015 classification guidelines changed the definition of the debated histological subtype LC to be based on immunomarkers for adenocarcinoma and squamous cancer. We sought to determine if these new guidelines translate
PurposeThis paper presents an integrated view of the literature published on all aspects and facets of competence in supply chain management (SCM) and furthermore provides a framework for classifying and analyzing literature to facilitate further study, practice, and research.Design/methodology/approachA systematic literature review identified 98 peer-reviewed scientific journal publications on th
