Background: Laquinimod is a novel immunomodulatory substance developed as an orally available disease modifying treatment in multiple sclerosis ( MS). The purpose of this study was to evaluate safety, tolerability, and efficacy on MRI lesions of two different doses of laquinimod compared with placebo in patients with relapsing MS. Methods: In this multicenter, double-blind, randomized trial, patie

A recent study of adenylate kinase reveals that conformational dynamics in control product release and determine the rate-limiting step in the overall catalytic reaction.

Combined convective and radiative heat transfer governs the heat load on the combustor wall. This paper reviews engineering simplified models and more advanced ones. The latter ones are based on CFD approaches and a variety of methods to solve the radiative transfer equation. The principles of heat transfer in the combustor including the cooling aspects are briefly described. Details of the advanc

The cutaneous parallel fiber (PF) receptive fields of cerebellar stellate and basket cells in the cerebellar C3 zone in vivo are normally very small but can be dramatically enlarged by climbing fiber (CF)-dependent plasticity. To analyze the effects of this receptive field plasticity, we present for the first time whole-cell patch-clamp recordings from these interneurons during natural and electri

In stanzic songs like hymns for congregational singing, the intimate relationship between the text and the tune that we find in through-composed art songs is rarely achieved. In the tradition of the Lutheran churches the music has mainly been the servant of the text. However, the work of the hymnal committee of the Church of Sweden, which compiled the hymnal of 1986, shows two major criteria for t

Is it possible and desirable to separate between science and pseudo science, between archaeology and pseudo archaeology? And should archaeologists igonore, understand or criticise pseudo archaeology? My experiences from the study of four traditions within the field of “sacred topographies” show, that it is rather difficult or even impossible to separate archaeology from pseudo archaeology. In the

Routine postmortem radiography was done in 234 consecutive perinatal autopsies. Using ossification centre appearance and length of femoral shafts as variable it was a very useful and dependable method for estimating gestational age and intrauterine growth. In this way important conclusions can be drawn as to the reason for intrauterine growth deviations. Also many, sometimes diagnostic, abnormalit

Denna rapport är ett exempel på hur man utför en noggrann fuktdimensionering av en byggnad. Till vår hjälp har vi en checklista som ska användas i projekteringen. Den presenteras i FUKTDIMENSIONERING MED GENERELL CHECKLISTA i rapporten TVBH-3031. Generella checklistor syftar till att kontrollera alla fuktbelastningar under en byggnads brukstid så att inte byggnaden får skador eller andra olägehet

Thromboembolic complications during pregnancy are major contributors to maternal death, but there is no reliable way to estimate the absolute risk of thrombosis before the occurrence of a thromboembolic complication. OBJECTIVE: To create a model for individual estimation of thrombosis risk during pregnancy and to determine the distribution of risk estimates in a series of gravidae. METHOD AND PATI

An excursion to Estonian Saaremaa is briefly reported on, where four botanists from department of systematic botany at university of Lund took part, hosted by professor Hans Trass and three colleagues from department of botany and ecology at Tartu state university. The excursions were mainly emphasized on the alvar localities in western Saaremaa and their lichen vegetation, which will be reported