In this article we describe and discuss implementation of a weighted simulation procedure, importance sampling, in the context of nonparametric linkage analysis. The objective is to estimate genome-wide p-values, i.e. the probability that the maximal linkage score exceeds a given threshold under the null hypothesis of no linkage. In order to reduce variance of the p-value estimate for large thresh

Past land use change has converted vast areas of Northern peatland by drainage to agricultural or forested land. This change often reduces the greenhouse gas (GHG) sink strength of peatlands or turns them even from sinks to sources, which affects the global climate. Therefore, there is a need for suitable mitigation options for GHG emissions from drained peatlands. Addition of wood ash to peatland

Microstructure evolution in thin Cu films during room temperature self-annealing is investigated by means of a mesoscale level set model. The model is formulated such that the relative, or collective, influence of anisotropic grain boundary energy, mobility and heterogeneously distributed stored energy can be investigated. Density functional theory (DFT) calculations are performed in the present w

BACKGROUND AND AIM: The genetic basis of Metabolic syndrome (MetS) is largely unknown but a link with salt sensitivity is recognized. The cytochrome P450 isoform 4F2 (CYP4F2) is involved in renal production of 20-hydroxyeicosatethraenoic acid (20-HETE), a natriuretic substance associated with salt sensitivity. The same enzyme is implicated in ω-hydroxylation of very long and medium chain fatty aci

Nations around the world are feverishly developing new standards relating to Building Information Modelling (BIM) in the construction industry which may enable teams to leverage greater value from BIM implementation and model authorship efforts. This study reflects on ongoing standardisation initiatives in Sweden and considers where current research efforts fit in. There is limited research presen

At the end of the 19th century, Wilhelm Windelband proposed a distinction between nomothetic and idiographic re-search, which became highly relevant for the discussion of the nature of psychological science. During the 20th cen-tury, a number of writers (including William Stern, Gordon Allport, James Lamiell and David Magnusson) have criti-cized the focus on variables rather than persons, and popu

Parathyroid hormone (PTH) is a principal regulator of calcium homeostasis. Previously, we studied single-nucleotide polymorphisms present in the major genes in the PTH pathway (PTH, PTHrP, PTHR1, PTHR2) in relation to bone mineral density (BMD) and fracture incidence. We found that haplotypes of the PTH gene were associated with fracture risk independent of BMD. In the present study, we evaluated

Open surgical total aortic arch replacement is a demanding procedure which carries a substantial morbidity and mortality. A less invasive endovascular option is endovascular stent grafting using in situ fenestrations. After thoracic stent graft deployment in the arch, fenestrations are made for the major arch vessels. During this procedure, antegrad cerebral perfusion is maintained using a tempora

Artikel om svartlistningen av filmarbetare i den amerikanska filmindustrin på 1940- och 1950-talen men också om dess eftermäle under 1960-talet.