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Natural variability in exposure to fine particles and their trace elements during typical workdays in an urban area

Studies on the natural human exposures to fine particulate matter (PM2.5) and their elements composition are practically non-existent in South America. In order to understand the natural exposure of the typical Brazilian population to PM2.5 and their trace element composition, we measured PM2.5 concentrations and collected mass on filters for nine continuous hours during a typical workday of volun

Geochemistry and U-Pb geochronology of 1590 and 1550 Ma mafic dyke swarms of western Laurentia : Mantle plume magmatism shared with Australia

Three new U–Pb ID-TIMS isotopic ages confirm previous evidence for two geochemically distinct, early Mesoproterozoic pulses of mafic magmatism along the western margin of Laurentia. The first is a U–Pb baddeleyite age of 1590 ± 5 Ma from a dyke swarm in the Tobacco Root Mountains of western Laurentia. It is the first evidence for magmatism of this age in west-central Laurentia. The second is a U–P

Vem har makten över universitetens historieundervisning?

Artikeln är en komparativ studie av historieundervisning vid amerikanska och svenska lärosäten. Skillnaderna till trots märks vissa gemensamma drag såsom att styrmekanismerna har blivit allt fler, vilket har inneburit att den enskilde läraren har fått allt mindre att säga till om, bland annat till följd av en marknadsanpassning av högre utbildning med fokus på mätbarhet och utvärderingar. Samtidig

The Gaia-ESO Survey: Evidence of atomic diffusion in M67

Investigating the chemical homogeneity of stars born from the same molecular cloud at virtually the same time is very important for our understanding of the chemical enrichment of the interstellar medium and with it the chemical evolution of the Galaxy. One major cause of inhomogeneities in the abundances of open clusters is stellar evolution of the cluster members. In this work, we investigate va

Academic leadership and commercial activities at research institutes : German evidence

This paper focuses on entrepreneurship by academic leaders. With the use of patents, inventions, and spin-offs to measure commercialization, and directors, research group leaders, and business owners as academic leaders, results, using a sample of more than 2,500 German researchers, show differences across academic leaders and commercialization. Findings for spin-offs are different from those for

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer

Phase-matched extreme-ultraviolet frequency-comb generation

Laser-driven high-order harmonic generation1,2 provides spatially3 and temporally4 coherent tabletop sources of broadband extreme-ultraviolet (XUV) light. These sources typically operate at low repetition rates, frep ≲ 100 kHz, where phase-matched HHG is readily achieved5,6. However, many applications demand the improved counting statistics or frequency-comb precision afforded by high repetition r

National trends in stunting, thinness and overweight among Chinese school-aged children, 1985–2014

Objective: We sought to examine changes in regional and sex disparities in stunting, thinness, and overweight among Chinese school-aged children from 1985 to 2014. Methods: We analyzed data on 1,489,953 children aged 7–18 years in the Chinese National Survey on Students’ Constitution and Health. Stunting, thinness, and overweight were defined according to WHO anthropomorphic definitions. After adj

Malaria parasites and related haemosporidians cause mortality in cranes : A study on the parasites diversity, prevalence and distribution in Beijing Zoo

Background: Malaria parasites and related haemosporidian parasites are widespread and may cause severe diseases in birds. These pathogens should be considered in projects aiming breeding of birds for purposes of sustained ex situ conservation. Cranes are the 'flagship species' for health assessment of wetland ecosystems, and the majority of species are endangered. Malaria parasites and other haemo

Targeting dendritic cells in pancreatic ductal adenocarcinoma

Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growin

Tumor Regression and Cure Depends on Sustained Th1 Responses

While immunomodulatory monoclonal antibodies (mAbs) have therapeutic efficacy against many tumors, few patients are cured. Attempting to improve their therapeutic efficacy we have applied the TC1 mouse lung carcinoma model and injected established subcutaneous tumors intratumorally with 3 weekly doses of various combinations of mAbs. Combinations of mAbs to CTLA4/PD1/CD137 (the 3 mAb combination)

The evolution and convergence of total quality management and management theories

This study compares the historical evolution of Total Quality Management (TQM) to eight well-known management theories to investigate whether there are affinities between TQM and the selected management theories. The study uses the core values and components of the EFQM Excellence Model as the framework for the analysis which reveals that most of the ingredients in the selected management theories

Reply to "comment on 'Ultrafast terahertz-field-driven ionic response in ferroelectric BaTiO3 ' "

In this reply to S. Durbin's comment on our original paper "Ultrafast terahertz-field-driven ionic response in ferroelectric BaTiO3," we concur that his final equations 8 and 9 more accurately describe the change in diffracted intensity as a function of Ti displacement. We also provide an alternative derivation based on an ensemble average over unit cells. The conclusions of the paper are unaffect

Global Value Chains, National Innovation Systems and Economic Development

The purpose of this paper is to examine the hypothesis that increased participation in global value chains (GVCs), such as assembly of imported parts for exports, leads to higher economic growth. The focus is particularly on the extent to which this holds for low-income countries, and the role that capability-building, i.e. development of the national innovation system, plays in the possibility of

Re-compartmentalizing local policies? The translation and mediation of European structural funds in Sweden

The local governments of EU member countries are attracted to the possibility of receiving EU funding. However, as the governance structures of EU funds are complex and dynamic, municipalities are increasingly drawing on the knowledge and resources of ‘EU experts’ who mediate and provide project support. This article contributes to our understanding of how EU cohesion policy is translated through

From one-sized to over-individualized? Service logic’s value creation

Purpose: There is a current trend in healthcare management away from produced and standardized one-size-fits-all processes toward co-created and individualized services. The purpose of this paper is to increase understanding of the value concept in healthcare organization and management by recognizing different levels of value (private, group and public) and the interconnectedness among these leve

Pseudolymphomatous Reaction to Red Tattoo Pigment

Decorative tattooing is a procedure in which exogenous pigment and/or dye is introduced into the dermis with the aim of creating a permanent skin decoration. The increasing prevalence of tattooed individuals leads to more reported tattoo-related complications. Pseudolymphomatous reaction is a benign reactive proliferation of lymphocytes that may uncommonly occur secondary to tattooing. We describe

Late mortality after autologous blood or marrow transplantation in childhood : A Blood or Marrow Transplant Survivor Study-2 report

Autologous blood or marrow transplantation (BMT) is a curative option for several types of childhood cancer. However, there is little information regarding the risk of late mortality. We examined all-cause mortality, relapse-related mortality (RRM), and nonrelapse-related mortality (NRM) in 2-year survivors of autologous BMT performed before age 22 between 1980 and 2010 at 1 of 2 US transplant cen