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The Missing Link : The implementation of priorities for research, development, and innovation

The thesis explores the ‘missing link’ in the study of priority-setting for research, development, and innovation (RDI), namely the processes of implementing RDI priorities, and the consequences of these processes. It does so by focusing on how choices, actions, and motivations of implementers of RDI priorities established elsewhere in the policy system enact, or carry out, the priorities, resulti

Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner

PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. Aspirin is a well-known non-steroid anti-inflammatory drug. This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). Here, we aimed to explore whether the anti-cancer effect

The enduring coloniality of ecological modernization : Wind energy development in occupied Western Sahara and the occupied Syrian Golan Heights

The dominant narratives on how to confront climate change are often presented as neutral proposals concerned with the well-being of the planet and its inhabitants. The main objective of this article is to exemplify how concepts like Ecological Modernization and Sustainable Development are used in the name of energy transitions to prolong illegal military occupations in two territories, namely occu

Sustained low catheter related infection (CRI) incidence in an observational follow-up study of 9924 catheters using automated data scripts as quality assurance for central venous catheter (CVC) management

Background: To maintain a low incidence of Catheter Related Infections (CRI) and Catheter Related Bloodstream Infections (CRBSI), continuous follow-up studies on catheter management are necessary. The aims of the present study were to investigate the incidence of catheter tip colonisation, CRI and CRBSI in the Region, to further explore the feasibility of automatic data collection and to investiga

Three perspectives on learning in a simulated patient scenario : a qualitative interview study with student, simulated patient, and teacher

INTRODUCTION: Patient simulation can be useful for medical students in developing communication skills for vulnerable situations. Three participants are primarily involved in the patient simulation activities: the student, the simulated patient (SP), and the teacher. We here aimed to explore these participants' perceptions of learning in a patient simulation scenario.METHODS: We conducted individu

Fostering collective climate action and leadership : Insights from a pilot experiment involving mindfulness and compassion

Recent research suggests that mindfulness, compassion, and self-compassion relate to inner transformative qualities/capacities and intermediary factors that can support increased pro-environmental behavior and attitudes across individual, collective, organizational, and system levels. However, current insights focus on the individual level, are restricted to certain sustainability fields, and wide

Long-term outcomes following adolescent metabolic and bariatric surgery

Severe obesity in adolescence negatively impacts upon health and wellbeing. Lifestyle modifications do not usually achieve a sufficient degree or durability of weight loss to mitigate the risk of medical complications. In recent years, metabolic and bariatric surgery (MBS), already a well-established treatment for adults with severe obesity, has emerged as an option in adolescents. Controlled stud

Polyhydroxyalkylations for alkali-stable cationic polymers as hydroxide exchange membranes

To alleviate worldwide dependence on fossil fuels for energy production and considerably reduce CO2 emissions, green energy sources and sustainable energy solutions are in high demand. Fuel cells are environmental-friendly electrochemical devices which may use clean fuels, e.g., green hydrogen gas, to generate electricity. Meanwhile, water electrolyzers provide an efficient strategy to produce gre

Habitat complexity affects microbial growth in fractal maze

The great variety of earth's microorganisms and their functions are attributed to the heterogeneity of their habitats, but our understanding of the impact of this heterogeneity on microbes is limited at the microscale. In this study, we tested how a gradient of spatial habitat complexity in the form of fractal mazes influenced the growth, substrate degradation, and interactions of the bacterial st

Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood : a prospective cohort study

Background: Screening for islet autoantibodies in children and adolescents identifies individuals who will later develop type 1 diabetes, allowing patient and family education to prevent diabetic ketoacidosis at onset and to enable consideration of preventive therapies. We aimed to assess whether islet autoantibody screening is effective for predicting type 1 diabetes in adolescents aged 10−18 yea

Shape optimization for the strong routing of light in periodic diffraction gratings

In the quest for the development of faster and more reliable technologies, the ability to control the propagation, confinement, and emission of light has become crucial. The design of guide mode resonators and perfect absorbers has proven to be of fundamental importance. In this project, we consider the shape optimization of a periodic dielectric slab aiming at efficient directional routing of lig

Numerical solution of distributed-order time-fractional diffusion-wave equations using Laplace transforms

In this paper, we consider the numerical inverse Laplace transform for distributed order time-fractional equations, where a discontinuous Galerkin scheme is used to discretize the problem in space. The success of Talbot's approach for the computation of the inverse Laplace transform depends critically on the problem's spectral properties and we present a method to numerically enclose the spectrum

A spectral projection based method for the numerical solution of wave equations with memory

In this paper, we compare two approaches to numerically approximate the solution of second-order Gurtin–Pipkin type of integro-differential equations. Both methods are based on a high-order Discontinous Galerkin approximation in space and the numerical inverse Laplace transform. In the first approach, we use functional calculus and the inverse Laplace transform to represent the solution. The spect

Higher Order Composite DG approximations of Gross–Pitaevskii ground state : Benchmark results and experiments

Discontinuous Galerkin composite finite element methods (DGCFEM) are designed to tackle approximation problems on complicated domains. Partial differential equations posed on complicated domain are common when there are mesoscopic or local phenomena which need to be modelled at the same time as macroscopic phenomena. In this paper, an optical lattice will be used to illustrate the performance of t

Spectra of Gurtin-Pipkin type of integro-differential equations and applications to waves in graded viscoelastic structures

In this paper, we study spectral properties and spectral enclosures for the Gurtin-Pipkin type of integro-differential equations in several dimensions. The analysis is based on an operator function and we consider the relation between the studied operator function and other formulations of the spectral problem. The theory is applied to wave equations with Boltzmann damping.

On spurious solutions encountered in Helmholtz scattering resonance computations in Rd with applications to nano-photonics and acoustics

In this paper, we consider a sorting scheme for potentially spurious scattering resonant pairs in one- and two-dimensional electromagnetic problems and in three-dimensional acoustic problems. The novel sorting scheme is based on a Lippmann-Schwinger type of volume integral equation and can, therefore, be applied to structures with graded materials as well as to configurations including piece-wise

Computation of scattering resonances in absorptive and dispersive media with applications to metal-dielectric nano-structures

In this paper we consider scattering resonance computations in optics when the resonators consist of frequency dependent and lossy materials, such as metals at optical frequencies. The proposed computational approach combines a novel hp-FEM strategy, based on dispersion analysis for complex frequencies, with a fast implementation of the nonlinear eigenvalue solver NLEIGS. Numerical computations il