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Covert digital manipulation of vocal emotion alter speakers' emotional states in a congruent direction

Research has shown that people often exert control over their emotions. By modulating expressions, reappraising feelings, and redirecting attention, they can regulate their emotional experience. These findings have contributed to a blurring of the traditional boundaries between cognitive and emotional processes, and it has been suggested that emotional signals are produced in a goal-directed way a

A self-determination theory approach to predicting school achievement over time: The unique role of intrinsic motivation

Although many studies have examined the relation of academic motivation to school achievement using the Self-Determination Theory perspective, the results have been inconsistent. The present investigation represents the first systematic attempt to use a meta-analysis and controlled, longitudinal studies to examine the relations of specific types of motivation to overall academic achievement. The m

Viewpoints in Clinical Proteomics - when will proteomics deliver clinically useful information?

Proteomics has not delivered biomarkers of clinical value, despite massive efforts. The technologies that are emerging today have, however, the power to reach deep into proteomes and to identify patterns associated with different diseases. The study design is then crucial and sample quality, bioinformatic approaches, pre-validation, using independent patient cohort, need to attract increased atten

Appendicostomy in preschool children with anorectal malformation: successful early bowel management with a high frequency of minor complications.

Aim. The aim of this study is to evaluate postoperatively bowel symptoms of antegrade colon enema through appendicostomies in preschool children with anorectal malformation (ARM). Method. 164 children with ARM operated on with posterior sagittal anorectal plasty were included. The malformations were classified according to Krickenbeck classification. Seventeen children in preschool age had an appe

Blue laccase from Galerina sp.: Properties and potential for Kraft lignin demethylation

We purified a laccase isoenzyme, Lad 1 from Galerina sp. HC1 using a combination of anion exchange- and hydrophobic interaction chromatography. Lad l has a molecular mass of 64 kDa, an isoelectric point of 4, and 3.35 copper atoms/enzyme molecule. The enzyme has features typical of fungal blue laccases. The sequences of two internal peptides were highly similar to reported laccase sequences from o

Visualization of Different Flashback Mechanisms for H-2/CH4 Mixtures in a Variable-Swirl Burner

Flame flashback from the combustion chamber to the premixing section is a major operability issue when using high H-2 content fuels in lean premixed combustors. Depending on the flow-field in the combustor, flashback can be triggered by different mechanisms. In this work, three flashback mechanisms of H-2/CH4 mixtures were visualized in an atmospheric variable-swirl burner using high speed OH* che

Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines

Ahlgren AR, Cinthio M, Steen S, Nilsson T, Sjoberg T, Persson HW, Lindstrom K. Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. Am J Physiol Heart Circ Physiol 302: H1102-H1115, 2012. First published December 23, 2011; doi:10.1152/ajpheart.00470.2011.-The effects of catecholamines on longitudinal displacemen

Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable

Suppression of the external mitochondrial NADPH dehydrogenase, NDB1, in Arabidopsis thaliana affects central metabolism and vegetative growth.

Ca(2+)-dependent oxidation of cytosolic NADPH is mediated by NDB1, which is an external type II NADPH dehydrogenase in the plant mitochondrial electron transport chain. Using RNA interference, the NDB1 transcript was suppressed by 80% in Arabidopsis thaliana plants, and external Ca(2+)-dependent NADPH dehydrogenase activity became undetectable in isolated mitochondria. This was linked to a decreas

Interactions of DNA repair gene variants modulate chromosomal aberrations in healthy subjects.

Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual differences in its capacity are probably due to corresponding genetic variations

Rediversion after urinary diversion: A single-centre experience.

Abstract Objective. This study aimed to reveal the late results of rediversion after urinary diversion. Material and methods. From 1985 to 2009, 28 patients underwent rediversion at the Department of Urology, Lund University Hospital, Sweden. Median follow-up after rediversion was 147 months (range 7-300 months, interquartile range 63-214). The following rediversions were performed: ileal conduit,

Healthy Cities Phase V evaluation: further synthesizing realism.

In this article we reflect on the quality of a realist synthesis paradigm applied to the evaluation of Phase V of the WHO European Healthy Cities Network. The programmatic application of this approach has led to very high response rates and a wealth of important data. All articles in this Supplement report that cities in the network move from small-scale, time-limited projects predominantly focuse

Optical trapping of gold aerosols

Aerosol trapping has proven challenging and was only recently demonstrated. 1 This was accomplished by utilizing an air chamber designed to have a minimum of turbulence and a laser beam with a minimum of aberration. Individual gold nano-particles with diameters between 80 nm and 200 nm were trapped in air using a 1064 nm laser. The positions visited by the trapped gold nano-particle were quantifie

Blanket peat biome endangered by climate change

Blanket bog is a highly distinctive biome restricted to disjunct hyperoceanic regions. It is characterized by a landscape covering of peat broken only by the steepest slopes(1). Plant and microbial life are adapted to anoxia, low pH and low nutrient availability. Plant productivity exceeds soil organic matter decomposition, so carbon is sequestered over time. Unique climatic requirements, includin

Combined Measurement of the Higgs Boson Mass in pp Collisions at sqrt[s]=7 and 8 TeV with the ATLAS and CMS Experiments.

A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to

Encapsulated galanin-producing cells attenuate focal epileptic seizures in the hippocampus.

Encapsulated cell biodelivery (ECB) is a relatively safe approach, since the devices can be removed in the event of adverse effects. The main objectives of the present study were to evaluate whether ECB could be a viable alternative of cell therapy for epilepsy. We therefore developed a human cell line producing galanin, a neuropeptide that has been shown to exert inhibitory effects on seizures, m

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced nonvertebral fractures are enormous. We demonstrate here that Wnt16-deficient mice develop spontaneous fractures as a result of low cortical thickness and high cortical porosity. In contrast, trabecular bone volume is not alt

The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils.

A number of amyloidogenic variants of apolipoprotein A-I (apoA-I) have been discovered but most have not been analyzed. Previously, we showed that the G26R mutation of apoA-I leads to increased β-strand structure, increased N-terminal protease susceptibility and increased fibril formation after several days of incubation. In vivo, this and other variants mutated in the N-terminal domain (residues

Economic evaluation of lifestyle interventions for preventing diabetes and cardiovascular diseases.

Lifestyle interventions (i.e., diet and/or physical activity) are effective in delaying or preventing the onset of diabetes and cardiovascular disease. However, policymakers must know the cost-effectiveness of such interventions before implementing them at the large-scale population level. This review discusses various issues (e.g., characteristics, modeling, and long-term effectiveness) in the ec

Nonfouling Tunable beta CD Dextran Polymer Films for Protein Applications

Polymeric beta-cyclodextrin (beta CD) films tunable with respect to thickness and beta CD content were prepared in order to develop a suitable platform, allowing for inclusion of nonpolar guest molecules in the beta CD cavity, while suppressing nonspecific protein adsorption. The beta CD films were synthesized from linear beta CD dextran polymers, and grafted onto silicon oxide surfaces by "click"