Filetype
Cancer mortality is exacerbated by late-stage diagnosis. Liquid biopsies based on genomic biomarkers can noninvasively diagnose cancers. However, validation studies have reported ~10% sensitivity to detect stage I cancer in a screening population and specific types, such as brain or genitourinary tumors, remain undetectable. We investigated urine and plasma free glycosaminoglycan profiles (GAGomes
Background: Traumatic peripheral nerve injury is common and incurs significant cost to individuals and society. Healing following direct nerve repair or repair with autograft is slow and can be incomplete. Several bioengineered nerve wraps or devices have become available as an alternative to direct repair or autologous nerve graft. Nerve wraps attempt to reduce axonal escape across a direct repai
Discriminating between quark- and gluon-initiated jets has long been a central focus of jet substructure, leading to the introduction of numerous observables and calculations to high perturbative accuracy. At the same time, there have been many attempts to fully exploit the jet radiation pattern using tools from statistics and machine learning. We propose a new approach that combines a deep analyt
I denna korta essä påminner om djurets särskilda ställning i retorikteori, från fabeldjur till en metafor för retorisk kraft. Jag började mitt sökande i klassiska texter som fabler. Här används djur i metaforisk mening för att synliggöra mänskliga dilemman. I vår tid, med ett posthumanistiskt krav på att omvärdera vår relation till det andra räcker dock inte detta antropocentriska perspektiv på dj
Flicker, or more precisely temporal light modulation (TLM), has re-emerged as a problem with the introduction of LED-based lighting technology. TLM, meaning variations in light intensity over time, may have negative effect on human health, causing annoyance, headaches, eyestrain and migraine. the negative consequences of TLM create an obstacle to broad and rapid adaptation of the new LED-technolog
Accumulating evidence suggests that microglia and peripheral immune cells may play determinant roles in the pathogenesis of Parkinson's disease (PD). Consequently, there is a need to take advantage of immune-related models of PD to study the potential contribution of microglia and peripheral immune cells to the degeneration of the nigrostriatal system and help develop potential therapies for PD. I
This article aims to deepen understandings of physician–patient encounters by investigating views and perceptions held by Swedish physicians and care seekers on medicine access. Through a relational approach and a focus on materialities of medicines as fluid and contingent, we conceptualize medicine access as situated everyday practices and physician–patient encounters as embedded in sociomaterial
Background: Fracture risk assessment is still far from perfect within the geriatric population. The overall aim of this study is to better identify older women at risk for fractures, using a quantitative measure of frailty in conjunction with the web-based Fracture Risk Assessment Tool (FRAX®). Methods: This study was performed in the Osteoporosis Risk Assessment (OPRA) cohort of n = 1023, 75-year
Boken ger en inblick i sociologins djup och bredd genom att inspirera till fortsatt tänkande om det delade samhället. I den tredje upplagan har flera kapitel reviderats och boken har utökats med ett nyskrivet kapitel om regionala och geografiska skillnader för att ge ökad förståelse av ojämlikhet och förändring mellan stad och land och inom storstadsregionerna.Sedan sociologin grundades har ämnet
Background: Considering the adverse reactions to vaccination against coronavirus disease 2019 (COVID-19), some people, particularly the elderly and those with underlying medical conditions, are hesitant to be vaccinated. This study aimed to explore the prevalence of adverse reactions and provide direct evidence of vaccine safety, mainly for the elderly and people with underlying medical conditions
AIMS: To assess the association of genetically-predicted lipid traits and lipid-modification via licensed or investigational targets with heart failure (HF).METHODS AND RESULTS: Two-sample Mendelian randomization (MR) study was conducted using summary-level genome-wide association studies (GWASs) from UK Biobank and HERMES Consortium. Genetic variants obtained from UK Biobank GWAS data were select
Patient-derived tumor organoids have been established as promising tools for in vitro modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are commonly cultured in basement membrane extract (BME) which does not recapitulate the intricacies of the extracellular matrix (ECM). We combined CCA organoids (CCAOs) with native tumor and liver scaffolds, obtained by decellul
Acute Respiratory Distress Syndrome is one of the more common fatal complications in COVID-19, characterized by a highly aberrant inflammatory response. Pre-clinical models to study the effect of cell therapy and anti-inflammatory treatments have not comprehensively reproduced the disease due to its high complexity. This work presents a novel physiomimetic in vitro model for Acute Respiratory Dis
Social gaze has received much attention in social cognition research in both human and non-human animals. Gaze following appears to be a central skill for acquiring social information, such as the location of food and predators, but can also draw attention to important social interactions, which in turn promotes the evolution of more complex socio-cognitive processes such as theory of mind and soc
ObjectivesThe aim of this study was to explore elite Para athletes' and coaches' perceptions of experiences of athlete health monitoring.Materials and MethodsThis study used a qualitative design, applying a phenomenographical approach. Thirteen athletes and six coaches from two different socioeconomic contexts (the Swedish and South African Paralympic programs) participated. Data were collected th
Objective This scoping review examines how different levels and types of partial foot amputation affect gait and explores how these findings may affect the minimal impairment criteria for wheelchair tennis.Methods Four databases (PubMed, Embase, CINAHL and SPORTDiscus) were systematically searched in February 2021 for terms related to partial foot amputation and ambulation. The search was updated
