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Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review

Importance: Despite the large health burden, reliable data on sepsis epidemiology are lacking; studies using International Statistical Classification of Diseases and Related Health Problems (ICD)-coded hospital discharge diagnosis for sepsis identification suffer from limited sensitivity. Also, ICD data do not allow investigation of underlying pathogens and antimicrobial resistance. Objectives: To

Microstructure and microwave loss studies on epitaxial YBa2Cu3Ox thin films

Thin YBa2Cu3Ox films were grown on SrTiO3 or LaAlO3 single crystals by dc-magnetron reactive sputtering in argon/oxygen gas mixtures. Deposition temperatures ranged from 540 °C to 780 °C. After deposition and subsequent cool down, films grown above 680 °C are superconducting below 86–88 K. All films are oriented with the [001] direction parallel to the [001] substrate normal. The best films have c

Formation of polyhedral voids at surface cusps during growth of epitaxial TiN/NbN superlattice and alloy films

Epitaxial TiN/NbN(001) superiattice thin films with periods A between 0 (alloy) and 9.6 nm have been grown by ultrahigh vacuum reactive magnetron sputter deposition on MgO(OOl) substrates in mixed Ar/N2 discharges. Cross-sectional transmission electron microscopy was used for characterizing layer and defect structure. Coherency strain relaxation close to the film/substrate interface resulted in no

PCI or CABG for left main coronary artery disease : The SWEDEHEART registry

Aims: An observational nationwide all-comers prospective register study to analyse outcomes after coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in unprotected left main coronary artery (LMCA) disease. Methods and results: All patients undergoing coronary angiography in Sweden are registered in the Swedish Web-system for Enhancement and Development of Evidence-b

Tibial Component Undersizing Is Related to High Degrees of Implant Migration Following Cementless Total Knee Arthroplasty : A Study of Radiostereometric Analysis Data for 111 Patients with 2-Year Follow-up

Background: Radiostereometric analysis (RSA) studies have shown that the continuous migration of tibial components is predictive of aseptic loosening following total knee arthroplasty (TKA). In the present study, we investigated whether accurate sizing and placement of tibial components are related to the degree of implant migration as measured with use of RSA.Methods:A total of 111 patients who u

Ion irradiation effects during growth of Mo/V(001) superlattices by dual-target magnetron sputtering

Epitaxial (001)-oriented Mo/V superlattice films with wavelengths of ≈ 5 nm have been grown on MgO(001) substrates, kept at 700°C, by dual-target unbalanced magnetron sputter deposition in Ar discharges. Low-energy (15-250 eV) Ar ion irradiation with incident ion-to-metal flux ratio of ≈ 1 during film growth was obtained through the application of a negative potential Vs to the substrate. The effe

δ-function-shaped Sb-doping profiles in Si(001) obtained using a low-energy accelerated-ion source during molecular-beam epitaxy

Two-dimensional (2D) buried delta-function-shaped Sb-doping profiles have been obtained in Si using a low-energy accelerated Sb-ion source during molecular-beam epitaxy. A combination of secondary-ion mass spectrometry (SIMS), capacitance-voltage (C-V) measurements, and cross-sectional transmission electron microscopy (XTEM) was used to investigate dopant distributions and to determine profile wid

Exposure levels of dust, endotoxin, and microorganisms in the Danish recycling industry

Introduction: Recycling of domestic waste and a number of employees in the recycling industry is expected to increase. This study aims to quantify current exposure levels of inhalable dust, endotoxin, and microorganisms and to identify determinants of exposure among recycling workers. Methods: This cross-sectional study included 170 full-shift measurements from 88 production workers and 14 adminis

Yttrium oxide inclusions in YBa2Cu3Ox thin films : Enhanced flux pinning and relation to copper oxide surface particles

Semi-coherent Y2O3 (yttria) inclusions are identified in high quality epitaxial YBa2Cu3Ox (YBCO) thin films by using transmission electron microscopy and energy dispersive X-ray analyses. Magnetization measurements show enhanced flux pinning in films containing an increasing number density of inclusions. The inclusions are incorporated into the films without disturbing the YBCO structure appreciab

TEM study of the early stages of the precipitation process in strip-cast Al3003 alloys

The precipitation behavior, especially the early nucleation stages, of the industrial strip-cast Al3003 alloys was investigated by using transmission electron microscopy (TEM). An icosahedral quasicrystalline phase was found as secondary particles in these strip-cast alloys after heat treatment for a few seconds. Three different nucleation paths are proposed based on the TEM observations. They hav

Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells

Pleural mesothelioma (PM) is an aggressive malignancy that develops in a unique tumor microenvironment (TME). However, cell models for studying the TME in PM are still limited. Here, we have generated and characterized novel human telomerase reverse transcriptase (hTERT)-transduced mesothelial cell and mesothelioma-associated fibroblast (Meso-CAF) models and investigated their impact on PM cell gr

PON-Fold : Prediction of Substitutions Affecting Protein Folding Rate

Most proteins fold into characteristic three-dimensional structures. The rate of folding and unfolding varies widely and can be affected by variations in proteins. We developed a novel machine-learning-based method for the prediction of the folding rate effects of amino acid substitutions in two-state folding proteins. We collected a data set of experimentally defined folding rates for variants an

Characterization of interfaces between hydrogenated amorphous carbon films and steel substrates using high resolution cross-sectional transmission electron microscopy

Cross-sectional transmission electron microscopy, including high resolution microscopy, was employed to characterize the interfaces between hydrogenated amorphous carbon (a-C:H) films and steel substrates. Films were deposited both by ion beam decomposition of large hydrocarbon molecules and by magnetron plasma decomposition of C2H2. The latter method was also used to deposit Mo- and W-containing

Compositional control of plane group symmetry in tourmalines : an experimental and computer simulated TEM, crystallographic image processing and Mossbauer spectroscopy study

Tourmalines with different compositions show different plane group symmetries in experimental high resolution transmission electron microscopy (HRTEM) when projected along the c-axis. Fe-poor elbaite shows p31m symmetry, while Fe-bearing elbaite shows p3m1 symmetry. Rubellite shows p6 symmetry, while Fe-Mg-Al-bearing tourmaline shows a `pseudo' p6 type of symmetry. Symmetries p3m1 and p6 are not c

Structural characterization of yttria (Y2O3) inclusions in YBa2Cu3O7−x films : Growth model and effect on critical current density

A higher critical current and enhanced pinning was obtained in c-axis-oriented YBa2Cu3O7−x (YBCO)films having a higher density of semicoherent yttria (Y2O3) inclusions. The films were grown by sputtering and the inclusion density depends on the fraction of N2O in the sputtering gas. The inclusions were studied by transmission electron microscopy, both in planar sections and in cross-sections. They

Microstructure of amorphous C:H and metal-containing C:H films deposited on steel substrates

Cross-sectional transmission electron microscopy (XTEM), including high-resolution microscopy (HREM), was employed to characterize the interface between different amorphous hydrogenated carbon (a-C:H) films and steel substrates. Additional analyses using Auger electron spectroscopy (AES) and X-ray diffraction (XRD) were also performed. Films were deposited both by high-energy (50 keV) nitrogen ion

Needles in a haystack: an intersectional analysis of the descriptive, constitutive and substantive representation of minoritised women

Using a data set of 1.1 million speeches drawn from UK House of Commons debates during 1997–2017 and a combination of automated and manual content analysis, this study addresses three interrelated questions. First, to what extent are minoritised women constitutively represented in parliamentary debates? Second, which MPs do so? Third, how do MPs’ race and gender affect how they represent minoritis

Reactive magnetron sputter deposition of CNx films on Si(001) substrates : film growth, microstructure and mechanical properties

There is currently considerable interest in producing new materials with extreme combinations of mechanical properties such as high hardnesses and moduli. One example of such a material is crystalline C3N4, which has been predicted to have a bulk modulus higher than that of diamond. In this paper we report on experiments carried out to synthesize CNx thin films. The films were grown in an unbalanc

The influence of thermal processing on structural and electrical properties of WxSi1−x/Si multilayers

Thermal stability of WxSi1−x/Si multilayers (MLs) with x varying from 1 to 0.11 is studied by TEM and LAXS. The structure of the prepared samples is amorphous. Doping of W sublayers with silicon affects the interdiffusion process as well as the crystallization in these sublayers. We investigated these two processes (which have a detrimental influence on e.g. X-ray mirror stability) by annealing ou

Transmission electron microscopy of InP Stranski‐Krastanow islands buried in GaInP

InP islands in a matrix of GaInP are investigated by transmission electron microscopy (TEM). The islands are uniform in size and shape, and are formed though self‐organized Stranski‐Krastanow growth. The introduction of a 4 ML intermediate GaP layer eliminates the bimodal distribution found in films where the InP was grown directly on the GaInP layer. The achieved island density is around 2 × 109