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Association of MC1R Variants and Host Phenotypes With Melanoma Risk in CDKN2A Mutation Carriers: A GenoMEL Study.

Background Carrying the cyclin-dependent kinase inhibitor 2A (CDKN2A) germline mutations is associated with a high risk for melanoma. Penetrance of CDKN2A mutations is modified by pigmentation characteristics, nevus phenotypes, and some variants of the melanocortin-1 receptor gene (MC1R), which is known to have a role in the pigmentation process. However, investigation of the associations of both

The Source of Jus Cogens Obligations: How Legal Positivism Copes with Peremptory International Law

If legal positivists wish to sustain their account of the international legal system, arguably, they have yet to explain how jus cogens obligations can derive from the usual norm-creating processes recognized by international law. This article provides such an explanation exactly. The explanation builds on the distinction between first order rules of jus cogens (commanding or prohibiting some cert

Även Sverige behöver en ny filmhistoria

Kulturartikel om ett planerat svenskt projekt att skriva en ny svensk filmhistoria och en möjlig förebild i det amerikanska projektet History of the American Cinema på University of California Press.

Intestinal damage in enterohemorrhagic Escherichia coli infection.

Enterohemorrhagic Escherichia coli (EHEC) infection leads to marked intestinal injury. Sigmoid colon obtained from two children during EHEC infection exhibited abundant TUNEL-positive cells. To define which bacterial virulence factors contribute to intestinal injury the presence of Shiga toxin-2 (Stx2), intimin and the type III secretion system were correlated with symptoms and intestinal damage.

Budgetary Control in Public Health Care - A Study about Perceptions of Budgetary Control among Clinical Directors

Health care expenditures have increased rapidly in most OECD-countries, and several reforms have been considered for the improvement of cost-containment in the health care sector. Physicians in particular have been recognized to have considerable impact on health care expenditures and as a result they have become increasingly involved in budgetary control with the hope of a more efficient use of r

Innovation in peripheral regions: Do collaborations compensate for a lack of local knowledge spillovers?

It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina

Att stoppa munnen till på bespottare och underrätta andra. Den akademiska undervisningen i svensk statsrätt under frihetstiden.

The aim of this dissertation is to study the education in constitutional law during the period 1719-1772, a period known as the Age of Liberty. According to the Instruments of Government 1719/1720, the actual power in the state was vested in the Diet, consisting of the four estates, all equal in voting matters. The royal will was bound to the majority in the State Council, its members beeing respo

The potential of industrial hemp (Cannabis sativa L.) for biogas production

Popular Abstract in Swedish Transportsektorn står för 63% av Sveriges använding av kol, olja och gas. Biobränslen som etanol, biodiesel och biogas står bara för 6.8% av energin som används för nationella transporter, biogas står för 12% av detta. Ökad produktion av biobränslen för transproter behöver inte betyda minskad produktion av jordbruks- och skogsråvaror för annat. Dels kan restprodukter anBiofuels are currently produced from agricultural crops, and an increasing use of crops for this application is expected in the EU in the years to come. The dominating crops cultivated in the EU for biofuel production today have a relatively large environmental impact. The European Energy Agency has identified several lignocellulosic crops, including industrial hemp, as more sustainable potential