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Development of autoimmune disease is the result of activation of the immune system that subsequently leads to tissue destruction. Although the clinical outcome significantly differs between autoimmune diseases, some pathogenic pathways could be shared. During the recent years, intense efforts to find the genetic factors behind development of the complex and polygenic autoimmune diseases have been

This thesis considers two different computational approaches for the analysis and synthesis of nonlinear systems. Each of these approaches is presented in a conference paper that describes parts of the theory and algorithms. Matlab commands implementing the algorithms have been developed and the manuals for these are included herein as well.

Abstract is not available

Latin hypercube sampling is suggested as a tool to improve the efficiency of different importance sampling methods for structural reliability analysis. In simple importance sampling, where the sampling centre is moved from the origin to the design point, standard Monte Carlo sampling can be replaced by Latin hypercube sampling. The efficiency improvement is then highly dependent on the choice of s

Med hjälp av elva fallstudier undersöktes hur livskvaliteten hos funktionshindrade påverkas av tillgången till ortopedtekniska (OT) hjälpmedel och professionella insatser. Resultatet tyder på att det finns stora skillnader i insatser för samma funktionshinder och därmed kostnader mellan olika personer som får OT-hjälpmedel. Den som lever ett mer aktivt liv och t ex sportar får i regel mer avancera

Ring preparations of the superficial buccal segment of the human facial vein, taken from extirpated tissue in 12 patients during neck surgery, were studied in vitro. The vein developed a maintained intrinsic myogenic tone in response to passive stretch and was supplied with alpha- as well as beta-adrenoceptors, both of which could be influenced by transmural nerve stimulation (TNS) and noradrenali

The single-dose effect of formoterol racemate and enantiomers on bronchodilatation up to 24 h was determined. Forty-six reversible asthmatic patients were randomised to this double blind, crossover study. Formoterol was inhaled by nebulizer (HaloLite(R)); 4.5 and 36 mug of the racemate (rac-formoterol), 2.25 and 18 mug of (R;R)-formoterol, 18 mug of (S;S)-formoterol, or placebo. Airway and systemi

A nasal spray formulation containing an extract of Artemisia abrotanum L. was developed for therapeutic use in patients with allergic rhinitis and other upper airway disorders. The nasal spray preparation used contains a mixture of essential oils (4 mg/ml) and flavonols (2.5 mug/ml), of which some components have been shown to possess antiinflammatory, expectorant, spasmolytic as well as antisepti

Recension av Chris Rodleys intervjubok med David Cronenberg.

Patients with chronic critical limb ischaemia (CLI) have a one-year mortality of around 20%, and a ten-year survival of around 25%, mainly due to concomitant cardio- and cerebrovascular atherosclerotic disease. Risk factors for the development of peripheral atherosclerosis and CLI are the same as for cardio- and cerebrovascular atherosclerosis; diabetes mellitus, hyperlipidaemia, arterial hyperten

The EU beta-glucan project is discussed together with the important diet related health issues, coronary heart disease and diabetes. Aspects considered include: effects of life-style and diet on the development of disease; the ability of cereal beta-glucans to lower plasma lipid levels and improve glucose tolerence; characteristics of beta-glucans; beta-glucans preparation and characterization; de

Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1

Neuroinformatics is the information science infrastructure of neuroscience. It relates to the tools, databases, models and mechanisms of information flow that serve all of the clinical and research efforts in this field. There have been several attempts to create neuroinformatic systems, but none seem to have reached wide spread adoption yet. This is especially true in the in the area of cognitive