The advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPMs). We examined the SPM rate in MM patients who were enrolled in the prospective observational CALM (Collaboration to Collect Autologous Transplant outcome in Lymphoma and Myeloma) study. Between 2008 and 2012, 3204 patients with MM underwent a first autologous hem

In temperate latitudes, many insects enter diapause (dormancy) during the cold season, a period during which developmental processes come to a standstill. The wood white (Leptidea sinapis) is a butterfly species distributed across western Eurasia that shows photoperiod-induced diapause with variation in critical day-length across populations at different latitudes. We assembled transcriptomes and

Witnessing violence toward a caregiver during childhood is associated with negative impact on children's health and development, and there is a need for effective interventions for children exposed to intimate partner violence in clinical as well as in community settings. The current effectiveness study investigated symptom reduction after participation in two established group interventions (one

While the global rush to control land resources is well established, ‘power-grabs’ in relation to marine and coastal resources are less well researched. Under the banner of ‘blue growth’, such power-grabs are taking shape through global policy processes that purportedly align the needs of the poor with profit interests and climate change concerns. This contribution critically interrogates these po

The Komstad Limestone forms a distal part of the widespread ‘orthoceratite limestone’ of the Baltoscandian continent. In this paper, we present an integrated conodont biostratigraphy and carbon isotope stratigraphy for a major part of this formation and address its significance for evaluating Middle Ordovician correlation and overall stratigraphy. Four conodont zones are distinguished, including t

Objective: The detection and analysis of atrial fibrillation (AF) in the ECG is greatly influenced by signal quality. The present study proposes and evaluates a model-based f-wave signal quality index (SQI), denoted S, for use in the QRST-cancelled ECG signal. Methods: S is computed using a harmonic f-wave model, allowing for variation in frequency and amplitude. The properties of S are evaluated

Consider the process which starts with N ≥ 3 distinct points on ℝd, and fix a positive integer K < N. Of the total N points keep those N - K which minimize the energy amongst all the possible subsets of size N - K, and then replace the removed points by K independent and identically distributed points sampled according to some fixed distribution ζ. Repeat this process ad infinitum. We obtain vario

Retail and place have always been in a dynamic interrelation throughout the history. However particularly in the last three decadesthere have been some radical shifts in the outcomes of this interrelationship. The spatial formation of stores, shopping streets,malls, and in turn, cities have dramatically changed. These contemporary shifts, formations and transformations in the retailgeographies hav

This article takes stock of recent changes to Sweden’s immigration policy and draws upon statistical data to show the effect of the new immigration regime. It discusses the structural economic challenge of integrating immigrants who lack education and job training, and offers Sweden as a reference (or perhaps cautionary tale) for other coun- tries seeking to change their immigration policies. This

In a world where climate goals are global but action remains firmly in the hands of states, reliable methods are needed to ensure that emissions reductions on a national level are not offset by carbon leakage. Appropriate indicators are needed to help policy makers set accurate targets for the carbon balance of their foreign trade and monitor the development of trade in a meaningful way. This pape

Multi-component transient signals show up in many different areas, most commonly in communication and radar but are also often found in measurements of human related signals, such as electrical responses of the heart and the brain. Transient signals are also typical in animal acoustic applications, e.g., dolphin echo locations and bird song syllables. The usual basis functions in linear modeling oMulti-component transient signals show up in many different areas, most commonly in communication and radar but are also often found in measurements of human related signals, such as electrical responses of the heart and the brain. Transient signals are also typical in animal acoustic applications, e.g., dolphin echo locations and bird song syllables. The usual basis functions in linear modeling o

The spectral characters of the electroencephalogram activity (EEG) is of interest both in studies of the EEG and in estimation oI Evoked Potentials. Often parametric methods assume an underlying model like AR or ARMA [1]. To avoid the model assumption a non-parametric multiple-window meihod for spectral estimation is used in this paper. The method uses Slepian's Discrete Prolate Spheroidal Wave Fu

A study is done concerning event related potentials in coloured noise, such as evoked potential signals (EP) in EEG. Two estimators, both based on the least square version of the Prony method, combined with singular value decomposition, have been investigated. The EP is described by a sum of damped sinusoids in both estimators. In the first estimator the noise is described by an ARMA—process and in