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Preparation of boronic acid-functionalized cryogels using modular and clickable building blocks for bacterial separation

Composite cryogels containing boronic acid ligands are synthesized for effective separation and isolation of bacteria. The large and interconnected pores in cryogels enable fast binding and release of microbial cells. To control bacterial binding, an alkyne-tagged boronic acid ligand is conjugated to azide-functionalized cryogel via the Cu(I)-catalyzed azide−alkyne cycloaddition reaction. The boro

Integrating genetics with newborn metabolomics in infantile hypertrophic pyloric stenosis

Introduction: Infantile hypertrophic pyloric stenosis (IHPS) is caused by hypertrophy of the pyloric sphincter muscle. Objectives: Since previous reports have implicated lipid metabolism, we aimed to (1) investigate associations between IHPS and a wide array of lipid-related metabolites in newborns, and (2) address whether detected differences in metabolite levels were likely to be driven by genet

Cell-Permeable Succinate Rescues Mitochondrial Respiration in Cellular Models of Statin Toxicity

Statins are the cornerstone of lipid-lowering therapy. Although generally well tolerated, statin-associated muscle symptoms (SAMS) represent the main reason for treatment discontinuation. Mitochondrial dysfunction of complex I has been implicated in the pathophysiology of SAMS. The present study proposed to assess the concentration-dependent ex vivo effects of three statins on mito-chondrial respi

Economic and environmental effects of replacing bottom trawling with fishing with creels

Bottom trawling is associated with negative external effects such as seafloor pressure and high fuel use. Replacing bottom trawls with passive gear, such as creels, is therefore interesting for policymakers. We investigate the response of the Norway lobster fishery in Sweden to an expanded creel area. Using an economic model (FishRent), we analyse fleet structure, net present value and two environ

Exposure to psychosocial work strain and changes in smoking behavior during pregnancy – A longitudinal study within the Danish national birth cohort

Objective Knowledge of the relationship between psychosocial strain in the work environment and smoking during pregnancy is scarce. This study aimed to examine the association between psychosocial job strain and change in smoking behavior during pregnancy. Methods The cohort included 65 645 pregnancies from the Danish National Birth Cohort (1996–2002), where pregnant women were interviewed on job

COVID-19 epidemic in Libya

The first case of COVID-19 was identified in Libya on 24/3/2020, and about 2 months later, the number of reported COVID-19 cases started to increase notably. The outbreak was first prominent in the southern region (Sabha) and then spread to the western and eastern parts of Libya. By 24/12/2020, the reported total number of deaths from COVID-19 reached 1415. There seems to be no published data on t

Heterogeneous hybrid entrepreneurs - Framing the variation in entrepreneurial effort and motives for hybrid entrepreneurship

This paper brings together two important distinctions in the study of entrepreneurship: the difference between full-time and hybrid entrepreneurship and the difference between productive and unproductive or predatory entrepreneurship. We combine the literature on hybrid entrepreneurship, primarily identifying significant differences compared with full-time entrepreneurs, with an adapted framework

Population biology and phenology of the colour polymorphic damselfly Ischnura elegans at its southern range limit in Cyprus

1. Geographically widespread species provide excellent opportunities to investigate how phenotypes change across large-scale environmental gradients. Temperature is a fundamental environmental variable and an important determinant of insect fitness. However, field research is often geographically restricted, and typically concentrated in northern latitudes. Basic population biology and phenotypic

Initial Report From a Swedish High-volume Transplant Center After the First Wave of the COVID-19 Pandemic

BACKGROUND: Solid organ transplant (SOT) recipients may be more vulnerable to coronavirus disease 2019 (COVID-19). Data on the clinical course of COVID-19 in immunosuppressed patients are limited, and the optimal management strategy for these patients is yet unclear. METHODS: We present 53 SOT recipients (31 kidney transplant recipients, 8 liver transplant recipients, 5 heart transplant recipients

Individual need and societal claims : Challenging the understanding of universalism versus selectivism in social policy

In this article, we argue that basic social policy concepts can fertilise the discussion on active labour market policy (ALMP). During the last decades, research on ALMP has become a flourishing field. This is an overall positive development. However, the development tends to fractionate the wider picture of social policy and distance the discussion from social policy seen as a multifold set of go

What can a heavy U(1)B−L Z boson do to the muon (g−2)µ anomaly and to a new Higgs boson mass?

The minimal U(1)B−L extension of the Standard Model (B-L-SM) offers an explanation for neutrino mass generation via a seesaw mechanism; it also offers two new physics states, namely an extra Higgs boson and a new Z′ gauge boson. The emergence of a second Higgs particle as well as a new Z′ gauge boson, both linked to the breaking of a local U(1)B−L symmetry, makes the B-L-SM rather constrained by d

Near-Surface Imaging of the Multicomponent Gas Phase above a Silver Catalyst during Partial Oxidation of Methanol

Fundamental chemistry in heterogeneous catalysis is increasingly explored using operando techniques in order to address the pressure gap between ultrahigh vacuum studies and practical operating pressures. Because most operando experiments focus on the surface and surface-bound species, there is a knowledge gap of the near-surface gas phase and the fundamental information the properties of this reg

Good indoor environmental quality (IEQ) and high energy efficiency in multifamily dwellings: How do tenants view the conditions needed to achieve both?

Sustainable housing that both creates good indoor environmental quality (IEQ) and avoids unnecessary energy use has proved difficult to realize. Renovations of multifamily houses provide an opportunity to find this balance. This study concerns whether tenants perceive that conditions for achieving sufficient IEQ with low energy use exist. Focus group interviews with 42 participants, in areas where

Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden

Summary: Romosozumab is a novel bone-building drug that reduces fracture risk. This health economic analysis indicates that sequential romosozumab-to-alendronate can be a cost-effective treatment option for postmenopausal women with severe osteoporosis at high risk of fracture. Purpose: To estimate the cost-effectiveness of sequential treatment with romosozumab followed by alendronate (“romosozuma

Dimensionality reduction in forecasting with temporal hierarchies

Combining forecasts from multiple temporal aggregation levels exploits information differences and mitigates model uncertainty, while reconciliation ensures a unified prediction that supports aligned decisions at different horizons. It can be challenging to estimate the full cross-covariance matrix for a temporal hierarchy, which can easily be of very large dimension, yet it is difficult to know a

Effects of the Japanese 2016 kumamoto earthquake on nitrate content in groundwater supply

The 2016 Kumamoto earthquake had a significant impact on groundwater levels and quality. In some areas, the groundwater level increased significantly due to the release of groundwater from upstream mountainous regions. Conversely, the groundwater level in other areas greatly decreased due to the creation of new fracture networks by the earthquake. There were also significant changes in certain gro