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DNA copy number amplifications in sarcomas with homogeneously staining regions and double minutes

To identify DNA amplifications in sarcomas, comparative genomic hybridization was performed on 27 cases that were likely to display high-level DNA copy number gains. In all cases, chromosome banding analysis had revealed homogeneously staining regions or double minutes, i.e., cytogenetic signs of gene amplification. In most cases, gains predominated over losses. Low-level amplifications (ratio 1.3

Den fysiska miljöns betydelse för sjukvård och omsorg : Ett miljöpsykologiskt perspektiv

Redan romarna anlade fältsjukhus i natursköna områden för att rehabiliteringen skulle fungera bra. Även i modern tid har man uppfört sjukhus i parkmiljöer i syfte att förbättra hälsan hos patienterna. Sjukhusen har gärna utformats så att det är lätt att ta sig ut till de omgivande markerna, fönstren vetter utåt och trädgårdar planeras för att ge patienterna kontakt med naturmiljön. I slutet av 180

Nationell ära och manlighet i Karl XII (1925) - en historisk filmanalys

During the 1920s, when the Swedish defence was under heavy debate, military and conservative forces on the right tried to turn the Swedish public opinion towards a climate more in favour of the defence by producing a big budget war film – Karl XII. In several senses the film became a great success. In Sweden the attendance figures were as high as one million (of a population of six) and the film w

Multicentre evaluation of IL Test (TM) Free PS: A fully automated assay to quantify Free Protein S

Deficiency of the anticoagulant vitamin K-dependent protein S (PS) is associated with increased risk of venous thrombosis. In human plasma, PS circulates in two forms: as free protein (free PS) and PS bound to C4b-binding protein (C4BP), a regulator of the complement system. Assays for free PS have higher sensitivity and specificity for protein S deficiency than assays for total protein S. We have

Trains of attosecond electron wave packets

We study temporally localized electron wave packets, generated using a train of extreme ultraviolet (XUV) attosecond pulses to ionize the target atoms. Both the electron wave packets and the attosecond pulse train ( APT) are characterized using the same technique, based on interference of two-photon transitions in the continuum. We study, in particular, the energy transfer from a moderately strong

The electronic spectrum of the UO2 molecule

The electronic spectrum of the UO2 Molecule has been determined using multiconfigurational wave functions together with the inclusion spin-orbit coupling. The molecule has been found to have a (5fphi)(7s), (3)Phi(2u), ground state. The lowest state of gerade symmetry, H-3(4g), corresponding to the electronic configuration (5f)(2) was found 3330 cm(-1) above the ground state. The computed energy le

The effects of successful intervention on quality of life in patients with varying degrees of lower-limb ischaemia

OBJECTIVES: to assess the quality of life after successful intervention among patients with varying degrees of lower-limb ischaemia in comparison with healthy controls and the respondents>> degree of sense of coherence. MATERIALS AND METHODS: one hundred and twelve patients and 102 healthy controls were assessed for quality of life (Nottingham Health Profile) and sense of coherence. MAIN RESULTS:

A road map towards defining the role of Smad signaling in hematopoietic stem cells.

The transforming growth factor-beta (TGF-beta) superfamily encompasses the ligands and receptors for TGF-beta, bone morphogenic proteins (BMPs), and Activins. Cellular response to ligand is context-dependent and may be controlled by specificity and/or redundancy of expression of these superfamily members. Several pathways within this family have been implicated in the proliferation, differentiatio

Vesicular-arbuscular mycorrizae for dating multiple paleosols and carbon loss rate determination

A promising technique for dating paleosols is reported based on radiocarbon (C-14) dating of asexual spores from vesicular-arbuscular mycorrizae (VAM). The soils are dispersed in water and some 6000-8000 spores separated by hand picking under a low power microscope. The dried spores are then dated by accelerator mass spectroscopy (AMS). A chronosequense of closely superimposed paleosols from an ar

Medical and surgical strategies for treating urogynecological disorders

Symptoms and signs of the urogenital estrogen deficiency syndrome occur relatively late in a women's life when endogenous estrogen levels are well below those required to stimulate endometrial growth. At age 60 and above symptoms are common and progress with advancing age. The first and most common complaint is vaginal dryness, but symptoms of lost control of micturition as well as urge incontinen

Three-dimensional crystal structure and enzymic characterization of beta-mannanase Man5A from blue mussel Mytilus edulis

Endo-beta-1,4-D-mannanase is the key depolymerizing enzyme for beta-1,4-mannan polymers present in the cell walls of plants and some algae, as well as in some types of plant seeds. Endo-1,4-beta-mannanase from blue mussel Mytilus edulis (MeMan5A) belongs to the glycoside hydrolase (GH) family 5 enzymes. The MeMan5A structure has been determined to 1.6 angstrom resolution using the multiple-wavelen

Temporally structured density-dependence and population management

We used a simple discrete-time population model to investigate how temporally structured density-dependence influences a population's response to loss due to harvesting. We assumed that reproduction is a relative discrete event in time, followed by density-dependent mortality and then harvesting, or followed by harvesting and then density-dependent mortality. Such an ordering of events in time may

Combined magnetic and structural investigation of nano crystalline iron oxides: The interplay between crystal size and phase composition during FeS2 oxidation

The oxides that form during thermal oxidation of natural FeS2 (pyrite and marcasite) consist of nanometer-sized crystals of alpha-Fe2O3 and gamma-Fe2O3. This is shown with heating experiments that were made up to 650 degrees C, which resembles temperatures used in metallurgical processes. It is shown that magnetic measurements can play a key role in the investigation of this reaction, due to the u