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Perspectives of working life research

We recently finished a position paper on Swedish working life research for the Swedish Council for Working Life and Social Research (1). An obvious question was the definition of "working life research". Searching the literature, we found a plethora of terms used to describe this area and lack of a generally accepted definition. It also became clear that the primary goals of such research varied w

The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men

Objectives We determined levels of cognitive functioning in community dwelling men aged 40-79 (n = 3265) from eight European centres and investigated to what extent cognitive performance varied between centres, the association between different cognitive domains and age, educational level, co-morbidity and lifestyle factors and the respective contributions of centre and individual factors to cogni

Symptoms in peri- and postmenopausal women in relation to testosterone concentrations: data from The Women's Health in the Lund Area (WHILA) study

Objectives The aim of this study was to investigate possible associations between androgen concentrations in perimenopausal women and symptoms that may be associated with low androgen concentrations in the blood. Methods All women born in the period 1935-1945 and living in a defined geographic area in Sweden (n=10 766) were invited to a screening program that included physical and laboratory exami

High potassium contents in organ preservation solutions cause strong pulmonary vasocontraction

Euro-Collins (ECS) and UCLA-formula organ preservation solutions induced strong vasocontraction in porcine pulmonary arteries when studied in organ baths at temperatures of 37 degrees C and 30 degrees C. At 20 degrees C ECS induced a 30% contraction, but at 6 degrees C no contraction (n = 5) or a weak contraction (n = 1) was elicited. Neither prostaglandin E1 nor nifedipine caused any significant

Supermacroporous poly(hydroxyethyl methacrylate) based cryogel with embedded bilirubin imprinted particles

Molecular imprinted polymers are artificial, template-made materials with the ability to recognize and to specifically bind the target molecule. The aim of this study is to prepare supermacroporous cryogel with embedded bilirubin-imprinted particles which can be used for the selective removal of bilirubin from human plasma. N-methacryloyl-(L)-tyrosinemethylester (MAT) was chosen as the pre-organiz

Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers

Helicobacter pylori is a world-wide spread bacterium that causes persistent infections and chronic inflammations that can develop into gastritis and peptic ulcer disease. It expresses several adhesin proteins on its surface that bind to specific receptors in the gastric epithelium. The most well-known adhesin is BabA, which has previously been shown to bind specifically to the fucosylated blood gr

Earth System governmentality Reflections on science in the Anthropocene

This paper examines Earth System Science as a novel approach to global environmental change research. Drawing upon Michel Foucault's governmentality concept, the paper opens up the Earth System metaphor to political analysis and asks what it does to our understanding of nature and society as a governable domain. We trace the scientific practices that have produced the Earth System as a thinkable a

Novel nanoelectronic device applications based on the nonlinearity of three-terminal ballistic junctions

Nanometer-scale electron devices containing three-terminal ballistic junctions are fabricated by electron-beam lithography on InP/InGaAs two-dimensional electron gas materials. Based on the intrinsic nonlinearity of the devices, frequency mixer, phase detector and RS flip-flop memory functioning at room temperature are successfully achieved. The devices have simple structure layout and small size,

Effects of anoxia and sulfide on concentrations of total and methyl mercury in sediment and water in two Hg-polluted lakes

Between May and December 1996, monthly samples of surface sediment (0-1 cm), settling matter, and water were taken at a shallow site and a deep site in each of two consecutive Hg-polluted riverine lakes. In the upper lake, the sediment was polluted also with cellulose fiber. Both hypolimnia turned anoxic, but sulfide was detected only in the upper lake. When sulfide appeared, hypolimnetic methyl m

CD44-stimulated human B cells express transcripts specifically involved in immunomodulation and inflammation as analyzed by DNA microarrays

A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B d

An automated on-line multidimensional HPLC system for protein and peptide mapping with integrated sample preparation

A comprehensive on-line two-dimensional 2D-HPLC system with integrated sample preparation was developed for the analysis of proteins and peptides with a molecular weight below 20 kDa. The system setup provided fast separations and high resolving power and is considered to be a complementary technique to 2D gel electrophoresis in proteomics. The on-line system reproducibly resolved similar to1000 p

Electrocardiographic changes in stroke patients without primary heart disease

Consecutive electrocardiograms were recorded in 28 stroke patients without signs of primary heart disease. Individuals with subarachnoidal haemorrhage, or electrolyte disturbances were excluded. A computerized tomography of the brain was performed in each case and showed a cerebral haemorrhage (n = 4), cortical infarction (n = 6), subcortical infarction (n = 14) and normal finding (n = 4). One pat

The Kullaberg peninsula – a glimpse of the Proterozoic evolution of SW Fennoscandia

The Kullaberg peninsula in NW Skåne renders km-long, continuous exposures of the Proterozoic crystalline basement. We report ion microprobe (SIMS) U–Pb zircon ages for six key lithologies at Kullaberg that constrain the geological history of SW Fennoscandia for a considerable time period. Igneous zircon in three varieties of gneiss granite yield ages of 1694±7 Ma, 1693±7 Ma and 1663±14 Ma, in the

Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammatory response on titanium implants

In vitro studies of titanium and TiO2 as well as other metals were carried out to investigate the role of these metals in the inflammatory response through the Fenton reaction. The TiOOH matrix formed traps the superoxide radical, so that no or very small amounts of free hydroxyl radicals are produced. Ellipsometry and spin trapping with spectrophotometry and electron spin resonance (ESR) were use

Use of neural networks to improve quality control of interpretations in myocardial perfusion imaging

Background: The aim of this study was to explore the feasibility of using a technique based on artificial neural networks for quality assurance of image reporting. The networks were used to identify potentially suboptimal or erroneous interpretations of myocardial perfusion scintigrams (MPS). Methods: Reversible perfusion defects (ischaemia) in each of five myocardial regions, as interpreted by on