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Diabetic retinopathy before and after cataract surgery

AIMS/BACKGROUND: Increased retinopathy progression has been reported after cataract surgery in patients with diabetes mellitus. To assess the influence of cataract surgery on visual acuity and retinopathy progression, all diabetic patients who were subjected to cataract surgery during 1991-3 have been followed up at the Department of Ophthalmology in Helsingborg. The average follow up time was 2 y

Reply to letter by Deng et al. "Could the levels of inflammation biomarkers predict OA? : Comment on the article by Roemer FW et al."

As explained in the methods-section, we chose to analyze the 2-year data in regard to inflammatory activity based on MRI and synovial biomarkers (and not earlier time points) as our aim was to capture patients that experienced "prolonged" or chronic inflammation, which may be regarded as a potential risk factor for osteoarthritis (OA) development. Virtually all patients of an acute injury cohort (

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer

Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-typ

Energy analysis and multi-objective optimization of waste heat and cold energy recovery process in LNG-fueled vessels based on a triple organic Rankine cycle

Due to the high level of pollutant emissions from traditional marine diesel engines, Liquefied Natural Gas (LNG) as clean energy is becoming a better choice for main engines to replace the traditional fuels. Meanwhile, in order to improve the energy efficiency of the marine power system, the Organic Rankine Cycle (ORC) has been regarded as the most suitable solution to recover the waste heat for t

Energy saving potential for integrated daylighting and electric lighting design via user-driven solutions: A literature review.

Measures for the reduction of electric energy loads for lighting have predominantly focussed on increasing the efficiency of lighting systems. This efficiency has now reached levels unthinkable a few decades ago. However, a focus on mere efficiency is physically limiting, and does not necessarily ensure that the anticipated energy savings actually materialise. This paper presents a literature surv

CSF and blood biomarkers for Parkinson's disease

In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease—the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help

Fysisk aktivitet ökar muskelstyrkan och minskar antalet fall

En av de mest växande medicinska problemen i samhället är den allt ökande frakturfrekvensen i befolkningen. Vilka individer som drabbas av en frakturberor på ett samspel mellan en rad olika faktorer som benmassan, skelettarkitekturen, muskelstyrkan, muskelfunktionen, balansen och falltendensen. Det har övertygande visats att fysisk aktivitet kan påverka en rad av dessa riskfaktorer för fraktur. Ök

Soluble CD163 and TWEAK in early pregnancy gestational diabetes and later glucose intolerance

Gestational diabetes mellitus (GDM) is today universally diagnosed during late pregnancy. Treating hyperglycaemia during pregnancy reduces the risk of complications, the effect of interventions is however limited due to the late diagnosis. It is thus important to identify biomarkers reaching a high precision for GDM development in early pregnancy. Here we aim to investigate soluble CD163 (sCD163)

Linking concepts of change and ecosystem services research: A systematic review

Transformation, transition and regime shift are increasingly applied concepts in the academic literature to describe changes in society and the environment. Ecosystem services represent one framework that includes the implicit aim of supporting transformation towards a more sustainable system. Nevertheless, knowledge and systematic reviews on the use of these concepts within ecosystem services res

Governance and stakeholder perspectives of managed re-alignment: adapting to sea level rise in the Inner Forth estuary, Scotland

With climate change, coastal areas are faced with unprecedented sea level rise and flooding, raising questions as to how societies will choose to adapt. One option is to strengthen existing sea walls to maintain current land uses; however, scientists, policy-makers and conservationists increasingly see the benefits of managed realignment, which is a nature-based coastal adaptation that involves th

An automatic method for measurements of arterial intima-media thickness using ultrasonic B-mode data

We have previously developed algorithms that use B-mode cineloops for simultaneous measurements of arterial diameter change and longitudinal movement of the arterial wall. In this study the lumen diameter algorithm was extended to also measure arterial intima-media thickness of the far wall. To optimize the algorithm the influence of the lateral width of the region-of-interest (1 pixel, 0.1 mm, 0.

Community engagement : The ‘last mile’ challenge for European research e-infrastructures

Europe is building its Open Science Cloud; a set of robust and interoperable e-infrastructures with the capacity to provide data and computational solutions through cloud-based services. The development and sustainable operation of such e-infrastructures are at the forefront of European funding priorities. The research community, however, is still reluctant to engage at the scale required to signa

Imaging features of CNS involvement in AIDS

Patients with acquired immunodeficiency syndrome (AIDS) are the subjects of a large part of routine neuroradiological work in the Western world currently. The World Health Organization announced that Turkish authorities had reported a cumulative total of 2544 HIV cases from 1985 to 2006, of whom 623 had developed AIDS and 140 had died. It is estimated that approximately one-third of AIDS patients