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Pattern of tumour growth of the primary colon cancer predicts long-term outcome after resection of liver metastases

Objective: To identify significant predictive factors for overall survival (OS) and disease-free survival (DFS) after liver resection for colon cancer metastases, with special focus on features of the primary colon cancer, such as lymph node ratio (LNR), vascular invasion, and perineural invasion. Methods: Patients operated for colonic cancer liver metastases between 2006 and 2014 were included. D

Established BMI-associated genetic variants and their prospective associations with BMI and other cardiometabolic traits : the GLACIER Study

Background:Recent cross-sectional genome-wide scans have reported associations of 97 independent loci with body mass index (BMI). In 3541 middle-aged adult participants from the GLACIER Study, we tested whether these loci are associated with 10-year changes in BMI and other cardiometabolic traits (fasting and 2-h glucose, triglycerides, total cholesterol, and systolic and diastolic blood pressures

Lower bone turnover and relative bone deficits in men with metabolic syndrome : a matter of insulin sensitivity? The European Male Ageing Study

Summary: We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with metabolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits. Introduction: Metabo

A simplified non-linear model of a drum boiler - turbine unit

In the analysis of power systems it is highly desirable to have models of the different power generators. In this paper we present, a model for a drum boiler whose purpose is to describe the gross behaviour of the boiler. The major control variables are fuel flow and control valve setting. The output variables are drum pressure and active output power. The model is verified by experiments on a 160

A randomized phase II/III study of naptumomab estafenatox + IFNα versus IFNα in renal cell carcinoma : Final analysis with baseline biomarker subgroup and trend analysis

Purpose: To prospectively determine the efficacy of naptumomab estafenatox (Nap) + IFNα versus IFN in metastatic renal cell carcinoma (RCC). Experimental Design: In a randomized, open-label, multicenter, phase II/III study, 513 patients with RCC received Nap (15 μg/kg i. v. in three cycles of four once-daily injections) + IFN (9 MU s. c. three times weekly), or the same regimen of IFN monotherapy.

Evaluation of cognitive subdomains, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D in the European Male Ageing Study

Purpose: Although lower levels of vitamin D have been related to poor cognitive functioning and dementia in older adults, evidence from longitudinal investigations is inconsistent. The objective of this study was to determine whether 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] levels are associated with specified measures of cognitive decline in ageing men. Methods: The

Survey of Applications of Identification in Dynamical and Physical Processes

Applications of system identification techniques to chemical, metallurgical, paper and pulp, cement and glass industries are surveyed. It is demonstrated that identification is a useful tool to determine process dynamics. This is true, particularly for processes which are difficult to model from basic physical laws only, such as blast furnaces, paper machines and cement kilns. Valuable knowledge i

Cardiovascular risk factors and ischemic heart disease

Background - Cardiovascular risk factors tend to aggregate. The biological and predictive value of this aggregation is questioned and genetics could shed light on this debate. Our aims were to reappraise the impact of risk factor confluence on ischemic heart disease (IHD) risk by testing whether genetic risk scores (GRSs) associated with these factors interact on an additive or multiplicative scal

Enhanced endothelin-1 mediated vasoconstriction of the ophthalmic artery may exacerbate retinal damage after transient global cerebral ischemia in rat

Cerebral vasculature is often the target of stroke studies. However, the vasculature supplying the eye might also be affected by ischemia. The aim of the present study was to investigate if the transient global cerebral ischemia (GCI) enhances vascular effect of endothelin-1 (ET-1) and 5-hydroxytryptamine/serotonin (5-HT) on the ophthalmic artery in rats, leading to delayed retinal damage. This wa

Radiostation Grafted Ion-Conducting Membranes: The Influence of Variations in Base Film Nanostructure

The proton exchange membrane (PEM) is a key element of a polymer electrolyte fuel cell, and radiation-grafting is an attractive option for the synthesis of PEMs. Via a systematic investigation of a well-defined model material, sulfonated polystyrene grafted poly(ethylene-alt-tetrafluoroethylene), ETFE-g-PS(SA), we show that the performance and stability of radiation-grafted PEMs in fuel cells stro

In vitro imaging of b-cells using fluorescent cubic bicontinuous liquid crystalline nanoparticles

To evaluate the potential of monoolein-based cubic bicontinuous liquid crystalline nanoparticles (cubosomes) as diagnostic tools in diabetes and pancreatic β-cell transplantation, fluorescent cubosomes were formulated, entrapping within the lipid bilayer a newly synthesized, potent, hydrophobic dye. Cryo-TEM, SAXS, and DLS were performed to assess the morphological and structural aspects of this f

Methodological challenges when doing research that includes ethnic minorities : a scoping review

Background: There are challenging methodological issues in obtaining valid and reliable results on which to base occupational therapy interventions for ethnic minorities. The aim of this scoping review is to describe the methodological problems within occupational therapy research, when ethnic minorities are included. Method: A thorough literature search yielded 21 articles obtained from the scien

Proteomic analysis of breast tumors confirms the mRNA intrinsic molecular subtypes using different classifiers : A large-scale analysis of fresh frozen tissue samples

Background: Breast cancer is a complex and heterogeneous disease that is usually characterized by histological parameters such as tumor size, cellular arrangements/rearrangments, necrosis, nuclear grade and the mitotic index, leading to a set of around twenty subtypes. Together with clinical markers such as hormone receptor status, this classification has considerable prognostic value but there is

The Association Between Psychiatric Disorders and Telomere Length : A Meta-Analysis Involving 14,827 Persons

OBJECTIVE: This study examined the relationship between leukocyte telomere length (LTL), a marker of cell aging, and psychiatric disorders in adults compared with controls using meta-analytic methods. METHODS: Data were abstracted from studies examining the relationship between LTL and adult psychiatric disorders. In addition to an overall estimate of effect size, subgroup analyses and meta-regres