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We describe a test which uses the ability of viable cells to reduce 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) to detect resistance to a bactericidal drug, rifampin, in in vitro-cultured Mycobacterium tuberculosis. The assay shows a linear relationship between the number of viable bacteria and the ability to reduce MTT. Dead mycobacteria were unable to reduce MTT. Rifampin

PURPOSE: To report a case of aortoenteric fistula secondary to endovascular abdominal aortic aneurysm (AAA) exclusion using the Stentor bifurcated endovascular graft. METHODS AND RESULTS: Seventeen months after a successful endovascular AAA procedure, a male patient developed upper gastrointestinal bleeding. An aortoenteric fistula was diagnosed. At operation, the endograft fabric was found to be

The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, in preparation for a Phase I clinical trial of boron neutron capture therapy. BSH was found to possess a linear disposition over the dosage interval investigated (up to 75 mg/kg). A bi-phasic blood pharmacokinetics was observed. Tumour-to-blood ratios showed variations between patients between 0.08 and 5.

Glycosylation and sulfation are two of the essential post-translational modifications of proteins. The slalom gene encodes a 3'-phosphoadenosine 5'-phosphosulfate transporter, a conserved protein found in organisms as diverse as plants and humans and required for sulfation of proteins. In Drosophila, slalom is exclusively expressed in salivary glands, which is unexpected, taken into account the ge

Popular Abstract in Swedish Avhandlingen består av en inledning och 4 artiklar. Den första artikeln, Young people and alcohol: an econometric analysis, analyser bestämningsfaktorerna för ungdomars konsumtion av alkohol ur ett hälsoekonomiskt perspektiv. Huvudresultatet i artikeln är att ungdomar som har föräldrar som är villiga att tillhandahålla alkohol till dem är mer benägna att dricka alkohol,This thesis consists of four essays on risky health behaviour among adolescents. In the first paper, Young people and alcohol: an econometric analysis, the purpose was to analyse the determinants of adolescent drinking behaviour within an economic-theoretical framework. The results showed that having parents willing to supply alcohol increased the frequency of beer-, wine-, and spirits-consumption

Abstract is not available

Utilisation of 'omics' technologies, in particular gene expression profiling, has increased dramatically in recent years. In basic research, high-throughput profiling applications are increasingly used and may now even be considered standard research tools. In the clinic, there is a need for better and more accurate diagnosis, prognosis and treatment response indicators. As such, clinicians have l

In the current thesis, the neurogenic and angiogenic response to electroconvulsive seizure (ECS)-treatment was investigated in the adult rat brain. ECS-treatment is an animal model for the antidepressant treatment electroconvulsive therapy (ECT), which is considered to be the most effective antidepressant treatment modality today, however with not yet fully understood modes of action. Depression,

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A new experimental technique to measure stopping forces for swift heavy ions was tested and has been found effective. A commercial PIN photodiode was coated with a patterned stopping medium of gold. This allowed the simultaneous detection of stopped- and reference-ions of C-14 and N-14 in the energy range E = 6.4-10.4 MeV. The stopping forces of these ions in gold have been measured with excellent

Results from a Monte Carlo investigation are presented for the application of the dual photopeak window (DPW) scatter correction method to phantom geometries of varying shapes, sizes, and densities as well as to several collimators. A Monte Carlo program was used to simulate a Tc-99m point source at locations of 0.5 cm from the phantom surface, at the center, 0.5 cm from the bottom, and 4/5 the di

High-resolution physical, mineralogical, sedimentological and micropalaeontological studies were carried out on North Atlantic cores from the Reykjanes Ridge at 59degreesN and from the region southwest of the Faeroe Islands. All core sites are situated along the pathway of Iceland-Scotland Overflow Water (ISOW) and the various parameters measured display similar features. Previously identified car

A mathematical model is presented for calculating heat release rate in the Room Corner Test, where lining materials are mounted on both walls and ceiling. The model is based on a thermal theory for concurrent flow flame spread. By using a simple mathematical representation of the heat release rate from the Cone Calorimeter, analytical solutions are arrived at for the velocity and position of the p

How is the conflict between a protection of accrued pension rights and economic, political and social interests in reforming the pension scheme resolved in different countries and regarding different kinds of pension schemes? What legal or political mechanisms exist to protect accrued pension rights and to resolve this conflict? This thesis takes a comprehensive view on the pension situation of t

A high order accurate and fast algorithm is constructed for 2D stress problems on multiply connected finite domains. The algorithm is based on a Fredholm integral equation of the second kind with non-singular operators. The unknown quantity is the limit of an analytic function. On polygonal domains there is a trade-off between stability and rate of convergence. A moderate amount of precomputation