The ability of new neurons to promote repair of brain circuitry depends on their capacity to re-establish afferent and efferent connections with the host. In this review article, we give an overview of past and current efforts to restore damaged connectivity in the adult mammalian brain using implants of fetal neuroblasts or stem cell-derived neuronal precursors, with a focus on strategies aimed t

Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell-derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell-derived cortical neurons send widespread axonal projections to both hemispheres of rats with ischemic

Soil microbiome is one of the most heterogeneous biological systems. State-of-the-art molecular approaches such as those based on single-amplified genomes (SAGs) and metagenome assembled-genomes (MAGs) are now improving our capacity for disentailing soil microbial-mediated processes. Here we analyzed publicly available datasets of soil microbial genomes and MAG's reconstructed from the Amazon's tr

Groundwater (GW) is being uncontrollably exploited in various parts of the world resulting from huge needs for water supply as an outcome of population growth and industrialization. Bearing in mind the importance of GW potential assessment in reaching sustainability, this study seeks to use remote sensing (RS)-derived driving factors as an input of the advanced machine learning algorithms (MLAs),

Woody pastures represent keystone habitats for biodiversity in agricultural landscapes, contributing to increased resource availability, landscape heterogeneity and structural variability. High taxonomic diversity is closely linked to vegetation structure in woody pastures, but examining functional characteristics of species assemblages can shed more light on the ecological mechanisms driving dive

Agricultural landscapes have changed fast in Europe, which has led to steep declines in farmland biodiversity. While this has differentially impacted “farmland species”, some of these seem to be able to use alternative man-made open habitats in forests, such as forest clear-cuts and powerline rights-of-way. We investigated the use of clear-cuts by two historically declining farmland birds, the Yel

Global climate change is projected to lead to an increase in both the areal extent and degree of aridity in the world’s drylands. At the same time, the majority of drylands are located in developing countries where high population densities and rapid population growth place additional pressure on the ecosystem. Thus, drylands are particularly vulnerable to environmental changes and large-scale env

Biogas production from wheat straw is one strategy of converting biomass to bioenergy, but pretreatment of the lignocellulosic material is necessary in order to render the substrate biodegradable. In this study, four different mechanical pretreatments of wheat straw were investigated: roll milling, extrusion, pelletization, and hammer milling. The effects of the pretreatments on anaerobic digestio

The Compex detector is an electrically cooled, composite germanium detector that uses four coaxial, cubic-shaped, single-encapsulated germanium crystals. This novel detector allows for new heights in photon detection efficiency in decay spectroscopy setups using box-shaped vacuum chambers. Its spectroscopic performance and detection efficiency is evaluated by means of source measurements. Motivate

User-related assessment of a level 3 automated driving system, providing functions such as lane- and distance-keeping, stop & go driving, lane change and overtaking, was carried out on a motorway in Germany with the aim to assess user-related issues of automated driving, i.e., behavior when driving with automation on motorways, user experiences, reactions and acceptance. Twenty-one persons dro

The phylogenetic relationships and possible origin of a putative non-native population of Podarcis muralis in Ukraine were assessed based on sequences of the mitochondrial gene cytochrome b. Phylogenetic analysis showed that the Ukrainian lizards belong to two distinct mitochondrial lineages (haplogroups), both occurring within the Central Balkan clade, which includes most of central and south-eas

Biochar has been extensively studied as a soil amendment for carbon sequestration and for improving soil quality; however, a systematic understanding of the responses of soil microbial biomass and diversity to biochar addition is lacking. Here, a meta-analysis of 999 paired data points from 194 studies shows that biochar increases microbial biomass but has variable effects on microbial diversity.

Diffusion tensor distribution (DTD) imaging builds on principles from diffusion, solid-state and low-field NMR spectroscopies, to quantify the contents of heterogeneous voxels as nonparametric distributions, with tensor “size”, “shape” and orientation having direct relations to corresponding microstructural properties of biological tissues. The approach requires the acquisition of multiple images

Background: Long-term exposure to air pollution increases the risk of cardiovascular morbidity and mortality, but the mechanisms are not fully known. Current evidence suggests that air pollution exposure contributes to the development of atherosclerosis. There are few studies investigating associations between air pollution and carotid plaques, a well-known precursor of cardiovascular disease. Met

The heat flux method is advantageous for obtaining adiabatic stretch-less flame and measuring laminar burning velocity, SL, with low uncertainty. However, its implementation is sometimes hampered by the instability, manifested as cellularity of the flame stabilized over a flat perforated burner. This paper summarizes the approaches of flame cellularity abatement on the heat flux burner, which are

The ongoing transition to renewable fuel sources has led to increased use of wood and other biomass fuels. The physiochemical characteristics of biomass combustion derived aerosols depends on appliances, fuel and operation procedures, and particles generated during incomplete combustion are linked to toxicity. Frequent indoor wood burning is related to severe health problems such as negative effec

Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, it suffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a good replacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLE was evaluated. An equipment consisting of a high-pressure view cell with on-line gas

BACKGROUND: Cancer occurrence among older people with intellectual disability (ID) is poorly documented, so we investigated the frequency and distribution of cancer in older people with ID compared with the general population.METHOD: People with ID who were ≥55years old and alive at the end of 2012 (n = 7936; ID cohort) were identified through a national register of people with ID who received soc

Aim: To investigate whether there was an association between periodontitis and airflow limitation in older Swedish individuals. Materials and Methods: Study individuals were randomly selected from the Swedish civil registration database representing the ageing population in Karlskrona, Sweden. Clinical and radiographic examinations were performed, alongside which participants completed questionnai

There is a lack of knowledge on mentally disordered sex offenders (MDSOs) targeting adult victims, especially regarding recidivism patterns and the specific subgroup with psychiatric disorders. This paper presents index offense data, clinical data, and recidivism patterns over up to 24 years in a cohort of 146 MDSOs, with and without psychotic disorders, sentenced in Sweden between 1993 and 1997.