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A web-based group course intervention for 15-25-year-olds whose parents have substance use problems or mental illness : Study protocol for a randomized controlled trial

Background: Depending on the definitions used, between 5 and 20 % of all Swedish children grow up with at least one parent suffering from alcohol problems, while 6 % have at least one parent who has received inpatient psychiatric care, conditions that may affect the children negatively. Nine out of ten Swedish municipalities therefore provide support resources, but less than 2 % of these children

Measurement-Based Wideband Analysis of Dynamic Multipath Propagation in Vehicular Communication Scenarios

Realistic propagation modeling requires a detailed understanding and characterization of the radio channel properties. This paper is based on channel sounder measurements with 1 GHz bandwidth at a carrier frequency of 5.7 GHz and particular tracking methods. We present statistical models for the number of, birth rate, lifetime, excess delay and relative Doppler frequency of individual multipath co

Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunizati

Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.

BACKGROUND: Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for mon

Distribution of the secretory leucocyte proteinase inhibitor in human articular cartilage

The secretory leucocyte protease inhibitor, SLPI, is a low molecular weight inhibitor of proteases such as elastase and cathepsin G, which are released from leucocytes during phagocytosis. The purpose of this study was to show whether or not SLPI is produced in articular chondrocytes. In articular disorders, the protease-antiprotease balance is disturbed. For this reason it would be interesting to

A Simple Method for Subspace Estimation with Corrupted Columns

This paper presents a simple and effective way of solving the robust subspace estimation problem where the corruptions are column-wise. The method we present can handle a large class of robust loss functions and is simple to implement. It is based on Iteratively Reweighted Least Squares (IRLS) and works in an iterative manner by solving a weighted least-squares rank-constrained problem in every it

U-Pb baddeleyite dating of the Proterozoic Pará de Minas dyke swarm in the São Francisco craton (Brazil) – implications for tectonic correlation with the Siberian, Congo and North China cratons

U–Pb baddeleyite ages demonstrate the presence of three dyke generations within the NW-trending Pará de Minas swarm (São Francisco craton, South America), dated at ca. 1795 Ma (1798 ± 4, 1791 ± 7 and 1793 ± 18 Ma), ca. 1710 Ma (1702 ± 13 and 1717 ± 11 Ma) and 766 ± 36 Ma. These ages have implications for the São Francisco-Congo (SF-Congo) craton within the Rodinia and Columbia supercontinent confi

Venous thromboembolism and cancer risk

Cancer increases the risk of venous thromboembolism (VTE) and about 20 % of all VTE are associated with cancer. VTE can also be used as a marker for occult cancer. The objective was to examine the correlation between VTE and cancer regarding predictors for a subsequent cancer diagnosis. Patients treated for VTE between January 1st 2006 and December 31th 2011 were extracted from the Swedish nationa

The failure of consulting professionalism? A longitudinal analysis of the Institute of Management Consultants

Abstract: This paper offers a longitudinal analysis of the Institute of Management Consultants (IMC). Drawing on archive sources, we consider the manner in which the IMC sought to institutionalize a form of expertise specific to management consultants. Rejecting attempts to locate the boundaries of such expertise within idealized, archetypal frameworks, we analyse the IMC’s attempts to secure occu

Unequal lands: Soil type, nutrition and child mortality in southern Sweden, 1850-1914

BackgroundChild mortality differed greatly within rural regions in Europe before and during the mortality decline. Not much is known about the role of nutrition in such geographic differences, and about the factors affecting the nutritional level and hence the resistance to diseases.ObjectiveFocusing on nutrition, we analyse the effects of soil type, used as an indicator of the farm-level agricult

Characterization of Relaxant Responses to Natriuretic Peptides in the Human Microcirculation In Vitro and In Vivo

Objective: We characterized the vasodilatory effects of ANP, BNP, and CNP in human subcutaneous arterioles in vitro and the cutaneous microcirculation in vivo. Methods: The in vitro experiments were performed using wire myography and the responses were characterized by the use of inhibitors for nitric oxide (L-NAME), prostaglandin synthesis (indomethacin), or the endothelium-derived hyperpolarizat

The role of CART in islet function

Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. We found that CART is expressed in human islet cells and that its expression is increased in patients with T2D, as w

C4b-binding protein protects β-cells from islet amyloid polypeptide-induced cytotoxicity

C4BP (C4b-binding protein) is a polymer of seven identical α chains and one unique β chain synthesized in liver and pancreas. We showed previously that C4BP enhances islet amyloid polypeptide (IAPP) fibril formation in vitro. Now we report that polymeric C4BP strongly inhibited lysis of human erythrocytes incubated with monomeric IAPP, whereas no lysis was observed after incubation with preformed

Kan samma XML stödja både HTML och VoiceXML? : En studie i voice browsing och VoiceXML

Denna magisteruppsats tar upp voice browsing utifrån den nya standarden VoiceXML. Uppsatsen är en undersökning av VoiceXML och XML. Undersökningens fokus ligger främst på de båda teknikerna, vars fördelar såväl som nackdelar presenteras och analyseras. XML ställs även i jämförelse med befintliga kompletterande tekniker som till exempel dess föregångare SGML och HTML. Undersökningen belyser och dis

Immediate and 5-year cumulative outcome after paediatric intensive care in Sweden

Background: Little has been reported about intensive care of children in Sweden. The aims of this study are to (I) assess the number of admissions, types of diagnoses and length-of-stay (LOS) for all Swedish children admitted to intensive care during the years 1998-2001, and compare paediatric intensive care units (PICUs) with other intensive care units (adult ICUs) (II) assess immediate (ICU) and

Early effect of gadopentetate and iodinated contrast media on rabbit kidneys

RATIONALE AND OBJECTIVES. The authors compared the physiologic and nephrotoxic effects of the magnetic resonance imaging contrast medium gadopentetate with two conventional radiographic contrast media. METHODS. Rabbits were injected intravenously with one of the following solutions: 1) gadopentetate (0.1 M); 2) iohexol (300 mg I/mL); 3) metrizoate (300 mg I/mL); and 4) NaCl (0.9%). Blood samples w