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A combined sample preparation and sample presentation device, Integrated Selective Enrichment Target (ISET), consisting of an array with 96 perforated nanovials is described. Each perforated nanovial can be filled with soild-phase extraction media for purification and concentration of biomolecules prior to mass spectrometry. The ISET platform provides an efficient, economic and generic sample trea

Brain hypothermia is at present the most effective neuroprotective treatment against brain ischemia in man. Ischemia induces a redistribution of proteins involved in synaptic functions, which is markedly diminished by therapeutic hypothermia (33 degrees C). Dendritic spines at excitatory synapses are motile and show both shape changes and rearrangement of synaptic proteins as a consequence of neur

The consumption of alcohol imposes costs on the society and several cost-of-illness studies have been conducted to estimate these costs. This essay presents the results from five cost-of-illness studies and examines the methodology used. The differences in results are discussed in reference to the differences in the applied methods. The results differ immensely from US$ 91 to US$ 2,433 per capita.

Molecularly imprinted polymers (MIPs) are being increasingly used as selective adsorbents in different analytical applications. To satisfy the different application purposes, MEN with well controlled physical forms in different size ranges are highly desirable. For examples, MIP nanoparticles are very suitable to be used to develop binding assays and for microfluidic separations, whereas MIP beads

Grounded theory (GT) is a popular research method for exploring human behavior. GT was developed by the medical sociologists Glaser and Strauss while they studied dying in hospitals in the 1960s resulting in the book "Awareness of dying". The goal of a GT is to generate conceptual theories by using all types of data but without applying existing theories and hypotheses. GT procedures are mostly in

In order to study the plasma levels of factor XaI and IIaI activity an enzymatically depolymerized low molecular weight heparin (LMW-heparin; Logiparin) was given s.c. in a dose of 35 XaI mu/kg b.w. once daily for 7 days to 10 patients undergoing total hip replacement (THR) in a pilot study. The XaI activity was less than or equal to 0.24 XaI units/ml and the IIaI activity less than or equal to 0.

The structure, luminescence spectroscopy, and lifetime decay dynamics of Eu2O3 nanoparticles formed in MCM-41 have been investigated. Both X-ray diffraction and high-resolution transmission electron microscopic observations indicate that Eu2O3 nanoparticles of monoclinic structure are formed inside channels of MCM-41 by heating at 140 degreesC. However, heat treatment at 600 or 700 degreesC causes

Recombinant factor VIIa (rFVIIa) has been developed for treatment of bleeding in patients with hemophilia who have inhibitors against factor VIII (FVIII) or FIX, and has been found to induce hemostasis during major orthopedic surgery. The use of rFVIIa treatment for hemophilia is a new concept and is based on the low-affinity binding of FVIIa to the surface of thrombin-activated platelets. Adminis

Popular Abstract in Swedish Metoder behövs att noggrant mäta rörelse och slitage av ledpannan efter operation med konstgjord höftled. EBRA-metoden (Ein Bild Röntgen Analyse) presenterades nyligen som en datoriserad metod att mäta rörelse av ledpannan. I denna studie utvärderades ett antal standardmetoder att mäta rörelse av ledpannan och jämfördes med radiostereometri (RSA), en metod som visats haMethods are needed for accurate measurement of acetabular cup migration and wear after hip replacement. The EBRA (Ein Bild Röntgen Analyse) method was recently introduced as a computerized method for radiographic assessment of acetabular cup migration. In this study, various standard methods for measuring migration were evaluated and compared to radiostereometry (RSA), which has proved to be high

Objectives To calculate the normal range for the fetal middle cerebral artery (MCA)/uterine artery pulsatility index (PI) ratio in the third trimester of pregnancy and to assess its value, compared with that of the MCA/umbilical artery PI ratio, in predicting an unfavorable outcome of pregnancies complicated by pre-eclampsia. Methods Doppler blood flow velocimetry of the uterine and umbilical arte

The aim of this work is practical. We show that the parameters of the widely used operational model of pharmacological agonism are difficult to estimate from single dose-response curves. The parameters can be estimated using pairs of dose-response curves (usually treatment and control) sharing some parameters. Confidence bands for the estimators are developed. In the case of multiple dose-response

Aim. To explore patients' evaluation of a specialized diabetes clinic for management of women with gestational diabetes born in Sweden and the Middle East and its contribution to a decreased level of stress and improved coping capability to promote health in patients receiving care. Background. No studies comparing patients' perceptions of healthcare in women of different origin with gestational

Phosphonic acid (H3PO3) is a candidate as an anchor group that can be used to bind a wide range of molecules to TiO2 surfaces, with practical applications for example in dye-sensitized solar cells. Adsorption geometries and energies of H3PO3 on the TiO2 anatase (1 0 1) surface have therefore been investigated using quantum-chemical periodic hybrid ab initio Hartree Fock density functional theory c

The Black-headed Gull Larus ridibundus is a monomorphic species with little size variation over its wide distribution range. This is in agreement with the wide dispersal of young birds and change of breeding sites of adults between years, which probably means an almost panmictic dispersal of genes. In 1965 I measured and weighed 319 eggs collected at Sjolunda near Malmo, southern Sweden. When I go

Study Design. Observational cohort study. Objective. To evaluate by MRI whether a vertebral fracture during childhood is a risk factor for degeneration of adjacent discs. Summary of Background Data. Several studies infer that trauma is a major cause of disc degeneration. Only 1 study has by magnetic resonance imaging (MRI) evaluated disc degeneration in children with a former thoracic or lumbar ve

Serine protease inhibitors (Serpins) are involved in the pathogenesis of neurodegenerative dementia, including the two most common types, Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB). The pathological characteristics of AD include senile plaques, mainly composed of aggregated amyloid-beta peptide (Abeta1-42), but also serpins, and neurofibrillary tangles of hyperphosphorylated tau