Search results

Background: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU). Methods: Retrospective study of 2434 patients (age <21 years) admitted to a PICU from 1 January 2006 through 31 March 2016 and captured in the Virtual Pediatric Systems database with ICD9 diagnosis 277.87, disorders of mitochondrial

Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant c

PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO A

This study presents a detailed investigation of the Velika Vrbica loess-palaeosol sequence, situated in the Wallachian Basin of northeastern Serbia, with the aim to reconstruct palaeoenvironmental changes spanning Marine Isotope Stages (MIS) 3 to 1. Using optically stimulated luminescence (OSL) dating, low field magnetic susceptibility (χlf), and mass accumulation rates (MARs), we have developed a

This book summarises fundamental methodologies in biological soil and water conservation measures, using the versatile Vetiver grass as a prime example. The material is derived from various student compendia and extension information letters on soil science and soil and water conservation written by Associate Professor Emeritus H. Jonas Åkerman between 1980 and 2000. Over a decade of long-term ass

Public libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associatiPublic libraries are increasingly acknowledged as important social infrastructures that can stimulate a sense of community, social cohesion and mental wellbeing. This paper investigates how (inter)national, provincial and local policies conceptualise and fund libraries as social infrastructures in three European cities. Drawing on 32 semi-structured interviews with library management and associati

Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (I

Japan's January withdrawal of funding from the UN Committee on the Elimination of Discrimination against Women highlights its aversion to addressing gender equality issues at home. Despite externally presenting a commitment to progressive gender norms, a tension between Japan's international image and its domestic reality persists. Japan continues to rank low in major gender equality indexes as re

In times of heightened dissensus over the liberal democratic order, normative theories of the EU need to adapt to be able to capture how the promotion and enforcement of values go hand in hand with their contestation. Research on global LGBT politics has shown that the promotion and enforcement of LGBT equality make possible and shape the anti-LGBT dissent it seeks to combat. Understood as a parad

This presentation focuses on a project at an early stage of development. The aim of the practice lab project is twofold: (i) to strengthen the competence among students in higher music education with regards to the topic of practice, and (ii) contribute to research on musical practice and skill acquisition. The project is conducted at Malmö Academy of Music (Lund university). Students take part in

Recent years has seen a number of music researchers taking interest in the concept of affordances. Although interpretation of the concept varies, a common denominator is that affordances are opportunities for actions emerging between a subject and the environment. As such, it is an analytical perspective that highlights material and embodied dynamics of musical practice, dimensions central to musi

OBJECTIVES: The Apollo study was designed to support the clinical performance verification of the adjusted cutoffs of the Elecsys® β-Amyloid(1-42) (Aβ42) cerebrospinal fluid (CSF) II, β-Amyloid(1-40) (Aβ40) CSF, Phospho-Tau (181P) (pTau) CSF and Total-Tau (tTau) CSF immunoassays (Roche Diagnostics International Ltd) for measuring fresh CSF samples, and assess the concordance of the Elecsys CSF pTa

The Swedish particle så is attested in different usages. In one of these, så introducesassertive clauses forming the foreground, or the skeleton, of a narrative. It is argued that, ifthe distribution of this particular particle is to be captured in a theory of syntax, such atheory needs to incorporate notions relating to narrative discourse or, in other words, atheory in which grammatical statemen

IMPORTANCE: Life expectancy is a composite health measure reflecting acute and life-course exposures. Identifying conditions behind disparities in life expectancy can guide policy, planning, and financing to battle the most urgent health problems.OBJECTIVE: To examine the contribution of 33 causes of death to life expectancy disparities, highlighting 2 sets of priority conditions-8 infectious and

Objective: The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are heterogeneous disorders. The aim of this study was to identify and characterize subgroups of patients based on sex, ANCA, age at diagnosis, and organ involvement. Methods: In total, 1,167 patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) were retrospectively recruited to the s

PURPOSE: Early identification of the underlying cause of intracerebral hemorrhage (ICH) is important for treatment and prognosis. This study aims to investigate the association of hematoma volume and other clinical parameters on the distribution of cerebral amyloid angiopathy (CAA) probability according to the simplified Edinburgh CT criteria in a large, unselected intracerebral hemorrhage (ICH) p

In scenarios coined Maxwell's demon, information on microscopic degrees of freedom is used to seemingly violate the second law of thermodynamics. This has been studied in the classical as well as the quantum domain. In this paper, we study an implementation of Maxwell's demon that can operate in both domains. In particular, we investigate information-to-work conversion over the quantum-to-classica

BackgroundComorbidity burden may affect the outcome following endovascular thrombectomy (EVT) for medium‐vessel occlusions. Since patients with high comorbidity burden are likely to be underrepresented in trials on EVT for medium‐vessel occlusions, observational data are needed to assess the benefit of EVT for these patients.MethodsWe conducted an observational study on all prestroke independent p

Objective: Following the favorable outcomes demonstrated by the Early MiNimally-invasive Removal of IntraCerebral Hemorrhage (ENRICH) trial in supratentorial intracerebral hemorrhage (ICH) patients treated with minimally invasive surgery (MIS), and considering the increasing interest in MIS, we aimed to assess the potential eligibility rate for ICH patients in Sweden. Methods: All patients with sp