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The relationship between the evolutionary dynamics observed in contemporary populations (microevolution) and evolution on timescales of millions of years (macroevolution) has been a topic of considerable debate. Historically, this debate centers on inconsistencies between microevolutionary processes and macroevolutionary patterns. Here, we characterize a striking exception: emerging evidence indic
Metabolic dysfunction-associated steatohepatitis (MASH) is a common but frequently unrecognized complication of obesity and type 2 diabetes. The association between these conditions is multifaceted and involves complex interactions between metabolic, inflammatory, and genetic factors. Here we assess the underlying structural and molecular processes focusing on the immunological phase of MASH in th
Neurogenesis continues throughout life in two key regions, the subventricular zone (SVZ) and dentate gyrus (DG), but declines with age alongside increased chronic inflammation and microglial activation. These neurogenic niches differ in their susceptibility to systemic changes, with the SVZ located near cerebrospinal fluid and the DG influenced by local neural activity. We found that immune change
The chapter examines and draws comparisons between modularity as a foundational production paradigm across code, platform society and electronic music production. It delves into the evolving landscape of music production within the context of platformization, highlighting the growing prevalence of modularity influenced by genres such as hip-hop and EDM. Additionally, the chapter explores how inter
FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time q
Background: Variation in residual volume between peritoneal dialysis dwells creates uncertainty in ultrafiltration determination, dialysis efficiency, and poses a risk of overfill if the residual volume is large. Measuring the dilution of a marker molecule during fluid fill offers a convenient approach, however, estimation accuracy depends on the choice of dilution marker. We here evaluate the fea
We consider two-dimensional steady periodic gravity waves on water of finite depth with a prescribed but arbitrary vorticity distribution. The water surface is allowed to be overhanging, and no assumptions regarding the absence of stagnation points and critical layers are made. Using conformal mappings and a new reformulation of Bernoulli’s equation, we uncover an equivalent formulation as “identi
New results on continuous time nonlinear consensus under varying topology are presented. The results are proved utilizing non Lyapunov based methods, i.e., the Hilbert metric, showing the possibility of further investigation of Hilbert metric for consensus and synchronization problems.
Background: Staphylococcus aureus bacteraemia (SAB) may lead to periprosthetic joint infections (PJI) via haematogenous spread of bacteria to the joint. Due to the risk of PJI, patients with SAB and prosthetic joint are recommended prolonged antibiotic treatment. The aim of the study was to assess the risk of PJI during SAB, and to evaluate if short treatment duration affects outcomes in patients
Den snabba utvecklingen av elektrifiering av vägtransporter i Sverige kräver forskningsbaserade beslut om placeringen av laddinfrastruktur. Europeiska unionens (EU) nya förordning för infrastruktur för alternativa bränslen (AFIR) specificerar det maximala tillåtna avståndet mellan offentliga snabbladdningsstationer (FCS) för tunga lastbilar längs det transeuropeiska transportnätverket (TEN-T). EffThe rapid progression of the electrification of road transport in Sweden requires effective research based decisions on the location of charging infrastructure. The new European Union (EU) regulation for alternative fuel infrastructure (AFIR) specifies the maximum allowed distance between public fast-charging stations (FCSs) for heavy-duty trucks along the Trans-European Transport Network (TEN-T).
In the current context of climate and anthropogenic change, assessing the adaptive capacity of coastal communities, i.e., their ability to adapt, navigate and/or recover from the impacts of change is key in coastal management and decision-making processes. Framing in adaptive capacity assessments (i.e., what is highlighted) influences how coastal communities’ adaptive capacity is perceived and und
The emergence of autonomous learning has revolutionized educational systems, offering new pathways to enhance higher education. Across most Swedish universities, Bachelor's and Master's theses (final projects) represent an important part of students' academic journey. Embracing technology as a tool, rather than an end in itself, has become imperative in contemporary higher education and thesis pro
Generative Artificial Intelligence (Gen AI), exemplified by models such as ChatGPT, has rapidly advanced, becoming a significant force in various sectors, including higher education. ChatGPT, a leading application of Gen AI, utilizes large language models (LLMs) to generate human-like text, providing capabilities that range from answering complex questions to facilitating software development. As
In recent years, Knowledge Management (KM) has gained significant attention within the Information Systems (IS) community. The economic importance of data and information, often likened to “data as the new oil,” underscores the critical role of data/information/knowledge management. KM is crucial in both educational and organizational contexts. Despite growing interest, research in KM in Higher Ed
In this research–in–progress paper, we employ design science research to articulate design knowledge for chatbots in higher education practice. We conducted a literature review to factor previous research into the design process. In addition, we performed a content analysis of student e-mails and forum posts from four instances of a basic Java programming course. Drawing from literature and data,
We use first-principle density functional theory (DFT) to predict properties for semicrystalline polyvinyl fluoride (PVF) and compare with polyvinylidiene fluoride. We note that the crystalline regions of PVF are complex in the sense that we lack a complete experimental characterization of the detailed atomic organization. We therefore turn to DFT to predict both the structure and associated mater
Background: Adolescence is an important period for development, when psychological problems may appear, including suicidal behavior. Experiencing Stressful Life Events (SLEs) is associated with increased risk of such problems, although the impact of distinct types of SLEs has seldom been examined. This study aims to analyze associations between different SLEs, psychological problems, subjective we
